- Human Studies of Angiogenic Gene Therapy
[作者：Gupta, R; Tongers, J; Losordo, DW,期刊：Circulation Research, 页码：724-736 , 文章类型： Review，,卷期：2009年105-8]
- Despite significant advances in medical, interventional, and surgical therapy for coronary and peripheral arterial disease, the burden of these illnesses remains high. To address this unmet need, the science of therapeut...
- Cardiac Na+ Current Regulation by Pyridine Nucleotides
[作者：Liu, M; Sanyal, S; Gao, G; Gurung, IS; Zhu, X; Gaconnet, G; Kerchner, LJ; Shang, LL; Huang, CLH; Grace, A; London, B; Dudley, SC,期刊：Circulation Research, 页码：737-U39 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Mutations in glycerol-3-phosphate dehydrogenase 1-like (GPD1-L) protein reduce cardiac Na+ current (I-Na) and cause Brugada Syndrome (BrS). GPD1-L has >80% amino acid homology with glycerol-3-phosphate dehydro...
- p300 Plays a Critical Role in Maintaining Cardiac Mitochondrial Function and Cell Survival in Postnatal Hearts
[作者：Nakagawa, Y; Kuwahara, K; Takemura, G; Akao, M; Kato, M; Arai, Y; Takano, M; Harada, M; Murakami, M; Nakanishi, M; Usami, S; Yasuno, S; Kinoshita, H; Fujiwara, M; Ueshima, K; Nakao, K,期刊：Circulation Research, 页码：746-U57 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: It is known that the transcriptional coactivator p300 is crucially involved in the differentiation and growth of cardiac myocytes during development. However, the physiological function of p300 in the postnata...
- Shear Stress Inhibits Homocysteine-Induced Stromal Cell-Derived Factor-1 Expression in Endothelial Cells
[作者：Sung, ML; Wu, CC; Chang, HI; Yen, CK; Chen, HJ; Cheng, JC; Chien, S; Chen, CN,期刊：Circulation Research, 页码：755-U81 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Hyperhomocysteinemia contributes to vascular dysfunction and risks of cardiovascular diseases. Stromal cell-derived factor (SDF)-1, a chemokine expressed by endothelial cells (ECs), is highly expressed in adva...
- Spontaneous Calcium Oscillations Regulate Human Cardiac Progenitor Cell Growth
[作者：Ferreira-Martins, J; Rondon-Clavo, C; Tugal, D; Korn, JA; Rizzi, R; Padin-Iruegas, ME; Ottolenghi, S; De Angelis, A; Urbanek, K; Ide-Iwata, N; D'Amario, D; Hosoda, T; Leri, A; Kajstura, J; Anversa, P; Rota, M,期刊：Circulation Research, 页码：764-U130 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: The adult heart possesses a pool of progenitor cells stored in myocardial niches, but the mechanisms involved in the activation of this cell compartment are currently unknown. Objective: Ca2+ promotes cell gro...
- Dual Pathways of Carbon Monoxide-Mediated Vasoregulation Modulation by Redox Mechanisms
[作者：Lamon, BD; Zhang, FF; Puri, N; Brodsky, SV; Goligorsky, MS; Nasjletti, A,期刊：Circulation Research, 页码：775-U142 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Vascular tissues produce carbon monoxide (CO) via HO-dependent and HO-independent mechanisms; the former in tandem with biliverdin and iron and the latter as a lone product. CO has been shown to function as bo...
- Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on beta-Adrenergic cAMP Signals
[作者：Abi-Gerges, A; Richter, W; Lefebvre, F; Mateo, P; Varin, A; Heymes, C; Samuel, JL; Lugnier, C; Conti, M; Fischmeister, R; Vandecasteele, G,期刊：Circulation Research, 页码：784-U161 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Multiple cyclic nucleotide phosphodiesterases (PDEs) degrade cAMP in cardiomyocytes but the role of PDEs in controlling cAMP signaling during pathological cardiac hypertrophy is poorly defined. Objective: Eval...
- Aldose Reductase Protects Against Early Atherosclerotic Lesion Formation in Apolipoprotein E-Null Mice
[作者：Srivastava, S; Vladykovskaya, E; Barski, OA; Kaiserova, MSK; Petrash, JM; Chung, SS; Hunt, G; Dawn, B; Bhatnagar, A,期刊：Circulation Research, 页码：793-U189 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Atherosclerotic lesion formation is associated with the accumulation of oxidized lipids. Products of lipid oxidation, particularly aldehydes, stimulate cytokine production and enhance monocyte adhesion; howeve...
- How Structure, Ca Signals, and Cellular Communications Underlie Function in Precapillary Arterioles
[作者：Borisova, L; Wray, S; Eisner, DA; Burdyga, T,期刊：Circulation Research, 页码：803-803 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: Precapillary arterioles control blood flow to tissues and their correct function is vital. However, their small size has limited study and little is known concerning the calcium signals in their endothelial an...
- Endogenous Activation of Mitochondrial K-ATP Channels Protects Human Failing Myocardium From Hydroxyl Radical-Induced Stunning
[作者：Maack, C; Dabew, ER; Hohl, M; Schafers, HJ; Bohm, M,期刊：Circulation Research, 页码：811-U222 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: During reperfusion of ischemic myocardium, a burst of hydroxyl radicals ((O) over dotH) induces contractile dysfunction ("myocardial stunning"), and O. H in the plasma of patients after myocardial infarction p...
- The Hedgehog Transcription Factor Gli3 Modulates Angiogenesis
[作者：Renault, MA; Roncalli, J; Tongers, J; Misener, S; Thorne, T; Jujo, K; Ito, A; Clarke, T; Fung, C; Millay, M; Kamide, C; Scarpelli, A; Klyachko, E; Losordo, DW,期刊：Circulation Research, 页码：818-U252 , 文章类型： Article，,卷期：2009年105-8]
- Rationale: The Gli transcription factors are mediators of Hedgehog (Hh) signaling and have been shown to play critical roles during embryogenesis. Previously, we have demonstrated that the Hh pathway is reactivated by is...
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