- Novel invadopodia components revealed by differential proteomic analysis
[作者:Attanasio, F; Caldieri, G; Giacchetti, G; van Horssen, R; Wieringa, B; Buccione, R,期刊:European Journal of Cell Biology, 页码:115-127 , 文章类型: Article,,卷期:2011年90-2]
- When highly invasive cancer cells are cultured on an extracellular matrix substrate, they extend proteolytically active membrane protrusions, termed invadopodia, from their ventral surface into the underlying matrix. Our...
- HDAC6 is required for invadopodia activity and invasion by breast tumor cells
[作者:Rey, M; Irondelle, M; Waharte, F; Lizarraga, F; Chavrier, P,期刊:European Journal of Cell Biology, 页码:128-135 , 文章类型: Article,,卷期:2011年90-2]
- Invasion across tissue boundaries by metastatic tumor cells depends on the proteolytic degradation of the extracellular matrix, initiated by the formation of invadopodia, actin-driven membrane protrusions with matrix-deg...
- PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: Role of matrix metalloprotease 9
[作者:Aung, CS; Hill, MM; Bastiani, M; Parton, RG; Parat, MO,期刊:European Journal of Cell Biology, 页码:136-142 , 文章类型: Article,,卷期:2011年90-2]
- Caveolae are specialized plasma membrane subdomains with a distinct lipid and protein composition, which play an essential role in cell physiology by performing trafficking and signalling functions. The structure and fun...
- Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton
[作者:Winograd-Katz, SE; Brunner, MC; Mirlas, N; Geiger, B,期刊:European Journal of Cell Biology, 页码:143-156 , 文章类型: Article,,卷期:2011年90-2]
- Cell adhesion to the extracellular matrix is mediated by adhesion receptors, mainly integrins, which upon interaction with the extracellular matrix, bind to the actin cytoskeleton via their cytoplasmic domains. This asso...
- Vinculin, an adapter protein in control of cell adhesion signalling
[作者:Carisey, A; Ballestrem, C,期刊:European Journal of Cell Biology, 页码:157-163 , 文章类型: Review,,卷期:2011年90-2]
- Vinculin, discovered in 1979 (Geiger, 1979), is an adapter protein with binding sites for more than 15 proteins. Biochemical and structural analyses have contributed to detailed knowledge about potential binding partners...
- Nck1 and Grb2 localization patterns can distinguish invadopodia from podosomes
[作者:Oser, M; Dovas, A; Cox, D; Condeelis, J,期刊:European Journal of Cell Biology, 页码:181-188 , 文章类型: Article,,卷期:2011年90-2]
- Invadopodia are matrix-degrading ventral cell surface structures formed in invasive carcinoma cells. Podosomes are matrix-degrading structures formed in normal cell types including macrophages, endothelial cells, and smo...
- Role of WASP in cell polarity and podosome dynamics of myeloid cells
[作者:Monypenny, J; Chou, HC; Banon-Rodriguez, I; Thrasher, AJ; Anton, IM; Jones, GE; Calle, Y,期刊:European Journal of Cell Biology, 页码:198-204 , 文章类型: Review,,卷期:2011年90-2]
- The integrin-dependent migration of myeloid cells requires tight coordination between actin-based cell membrane protrusion and integrin-mediated adhesion to form a stable leading edge. Under this mode of migration, polar...
- The cortactin-binding domain of WIP is essential for podosome formation and extracellular matrix degradation by murine dendritic cells
[作者:Banon-Rodriguez, I; Monypenny, J; Ragazzini, C; Franco, A; Calle, Y; Jones, GE; Anton, IM,期刊:European Journal of Cell Biology, 页码:213-223 , 文章类型: Article,,卷期:2011年90-2]
- In immature dendritic cells (DCs) podosomes form and turn over behind the leading edge of migrating cells. The Arp2/3 complex activator Wiskott-Aldrich Syndrome Protein (WASP) localises to the actin core of forming podos...
- Macrophage podosomes go 3D
[作者:Van Goethem, E; Guiet, R; Balor, S; Charriere, GM; Poincloux, R; Labrousse, A; Maridonneau-Parini, I; Le Cabec, V,期刊:European Journal of Cell Biology, 页码:224-236 , 文章类型: Article,,卷期:2011年90-2]
- Macrophage tissue infiltration is a critical step in the immune response against microorganisms and is also associated with disease progression in chronic inflammation and cancer. Macrophages are constitutively equipped ...
- p130Cas promotes invasiveness of three-dimensional ErbB2-transformed mammary acinar structures by enhanced activation of mTOR/p70S6K and Rac1
[作者:Tornillo, G; Bisaro, B; Camacho-Leal, MD; Galie, M; Provero, P; Di Stefano, P; Turco, E; Defilippi, P; Cabodi, S,期刊:European Journal of Cell Biology, 页码:237-248 , 文章类型: Article,,卷期:2011年90-2]
- ErbB2 over-expression is detected in approximately 25% of invasive breast cancers and is strongly associated with poor patient survival. We have previously demonstrated that p130Cas adaptor is a crucial mediator of ErbB2...
- Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation
[作者:Sen, S; Tewari, M; Zajac, A; Barton, E; Sweeney, HL; Discher, DE,期刊:European Journal of Cell Biology, 页码:249-260 , 文章类型: Article,,卷期:2011年90-2]
- Anchorage to matrix is mediated for many cells not only by integrin-based focal adhesions but also by a parallel assembly of integral and peripheral membrane proteins known as the Dystroglycan Complex. Deficiencies in ei...
- Specificities of beta(1) integrin signaling in the control of cell adhesion and adhesive strength
[作者:Regent, M; Planus, E; Bouin, AP; Bouvard, D; Brunner, M; Faurobert, E; Millon-Fremillon, A; Block, MR; Albiges-Rizo, C,期刊:European Journal of Cell Biology, 页码:261-269 , 文章类型: Article,,卷期:2011年90-2]
- Cells exert actomyosin contractility and cytoskeleton-dependent force in response to matrix stiffness cues. Cells dynamically adapt to force by modifying their behavior and remodeling their microenvironment. This adaptat...
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