- Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis
[作者:Lacroix, M; Caramel, J; Goguet-Rubio, P; Linares, LK; Estrach, S; Hatchi, E; Rodier, G; Lledo, G; de Bettignies, C; Thepot, A; Deraison, C; Chebli, K; Hovnanian, A; Hainaut, P; Dubus, P; Sardet, C; Le Cam, L,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21076-21081 , 文章类型: Article,,卷期:2010年107-49]
- A growing body of evidence suggests that the multifunctional protein E4F1 is involved in signaling pathways that play essential roles during normal development and tumorigenesis. We generated E4F1 conditional knockout mi...
- Paradoxical effects of constitutive human IL-32 gamma in transgenic mice during experimental colitis
[作者:Choi, J; Bae, S; Hong, J; Ryoo, S; Jhun, H; Hong, K; Yoon, D; Lee, S; Her, E; Choi, W; Kim, J; Azam, T; Dinarello, CA; Kim, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21082-21086 , 文章类型: Article,,卷期:2010年107-49]
Inflammatory cytokines mediate inflammatory bowel diseases ( IBDs) and cytokine blocking therapies often ameliorate the disease severity. IL-32 affects inflammation by increasing the production of IL-1, TNF alpha, and...
- Role for a somatically diversified lectin in resistance of an invertebrate to parasite infection
[作者:Hanington, PC; Forys, MA; Dragoo, JW; Zhang, SM; Adema, CM; Loker, ES,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21087-21092 , 文章类型: Article,,卷期:2010年107-49]
- Invertebrates lack adaptive immune systems homologous to those of vertebrates, yet it is becoming increasingly clear that they can produce diversified antigen recognition molecules. We have previously noted that the snai...
- Increased expression of leukotriene C-4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm
[作者:Di Gennaro, A; Wagsater, D; Mayranpaa, MI; Gabrielsen, A; Swedenborg, J; Hamsten, A; Samuelsson, B; Eriksson, P; Haeggstrom, JZ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21093-21097 , 文章类型: Article,,卷期:2010年107-49]
- Leukotrienes (LTs) are arachidonic acid-derived lipid mediators involved in the pathogenesis and progression of diverse inflammatory disorders. The cysteinyl-leukotrienes LTC4, LTD4, and LTE4 are important mediators of a...
- MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)
[作者:Valeri, N; Gasparini, P; Braconi, C; Paone, A; Lovat, F; Fabbri, M; Sumani, KM; Alder, H; Amadori, D; Patel, T; Nuovo, GJ; Fishel, R; Croce, CM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21098-21103 , 文章类型: Article,,卷期:2010年107-49]
- The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of tumor suppressor genes including p21, phosphatase and tensin ho...
- Using return on investment to maximize conservation effectiveness in Argentine grasslands
[作者:Murdoch, W; Ranganathan, J; Polasky, S; Regetz, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20855-20862 , 文章类型: Article,,卷期:2010年107-49]
- The rapid global loss of natural habitats and biodiversity, and limited resources, place a premium on maximizing the expected benefits of conservation actions. The scarcity of information on the fine-grained distribution...
- Comprehensive genetic testing for hereditary hearing loss using massively parallel sequencing
[作者:Shearer, AE; DeLuca, AP; Hildebrand, MS; Taylor, KR; Gurrola, J; Scherer, S; Scheetz, TE; Smith, RJH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21104-21109 , 文章类型: Article,,卷期:2010年107-49]
- The extreme genetic heterogeneity of nonsyndromic hearing loss (NSHL) makes genetic diagnosis expensive and time consuming using available methods. To assess the feasibility of target-enrichment and massively parallel se...
- Exogenously administered secreted frizzled related protein 2 (Sfrp2) reduces fibrosis and improves cardiac function in a rat model of myocardial infarction
[作者:He, W; Zhang, LN; Ni, AG; Zhang, ZP; Mirotsou, M; Mao, L; Pratt, RE; Dzau, VJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:21110-21115 , 文章类型: Article,,卷期:2010年107-49]
- Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of mammalian Tolloid-like 1 metalloprotein...
- Teleportation-based realization of an optical quantum two-qubit entangling gate
[作者:Gao, WB; Goebel, AM; Lu, CY; Dai, HN; Wagenknecht, C; Zhang, QA; Zhao, B; Peng, CZ; Chen, ZB; Chen, YA; Pan, JW,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:20869-20874 , 文章类型: Article,,卷期:2010年107-49]
- In recent years, there has been heightened interest in quantum teleportation, which allows for the transfer of unknown quantum states over arbitrary distances. Quantum teleportation not only serves as an essential ingred...
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