- Microbial community transcriptomes reveal microbes and metabolic pathways associated with dissolved organic matter turnover in the sea
[作者:McCarren, J; Becker, JW; Repeta, DJ; Shi, YM; Young, CR; Malmstrom, RR; Chisholm, SW; DeLong, EF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16420-16427 , 文章类型: Article,,卷期:2010年107-38]
- Marine dissolved organic matter (DOM) contains as much carbon as the Earth's atmosphere, and represents a critical component of the global carbon cycle. To better define microbial processes and activities associated with...
- Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage
[作者:Corbeaux, T; Hess, I; Swann, JB; Kanzler, B; Haas-Assenbaum, A; Boehm, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16613-16618 , 文章类型: Article,,卷期:2010年107-38]
- The thymus is essential for T-cell development. Here, we focus on the role of the transcription factor Foxn1 in the development and function of thymic epithelial cells (TECs) of the mouse. TECs are of endodermal origin; ...
- Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia
[作者:Pancewicz, J; Taylor, JM; Datta, A; Baydoun, HH; Waldmann, TA; Hermine, O; Nicot, C,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16619-16624 , 文章类型: Article,,卷期:2010年107-38]
- The Notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis. Unregulated activation of Notch signaling can result in excessive cellular proliferation and cancer. Human T-...
- Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice
[作者:Stevenson, WS; Hyland, CD; Zhang, JG; Morgan, PO; Willson, TA; Gill, A; Hilton, AA; Viney, EM; Bahlo, M; Masters, SL; Hennebry, S; Richardson, SJ; Nicola, NA; Metcalf, D; Hilton, DJ; Roberts, AW; Alexander, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16625-16630 , 文章类型: Article,,卷期:2010年107-38]
- With the notable exception of humans, uric acid is degraded to (S)-allantoin in a biochemical pathway catalyzed by urate oxidase, 5-hydroxyisourate (HIU) hydrolase, and 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decar...
- A Trojan horse mechanism of bacterial pathogenesis against nematodes
[作者:Niu, QH; Huang, XW; Zhang, L; Xu, JP; Yang, DM; Wei, KB; Niu, XM; An, ZQ; Bennett, JW; Zou, CG; Yang, JK; Zhang, KQ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16631-16636 , 文章类型: Article,,卷期:2010年107-38]
- Understanding the mechanisms of host-pathogen interaction can provide crucial information for successfully manipulating their relationships. Because of its genetic background and practical advantages over vertebrate mode...
- Cell adhesion-dependent membrane trafficking of a binding partner for the ebolavirus glycoprotein is a determinant of viral entry
[作者:Dube, D; Schornberg, KL; Shoemaker, CJ; Delos, SE; Stantchev, TS; Clouse, KA; Broder, CC; White, JM,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16637-16642 , 文章类型: Article,,卷期:2010年107-38]
- Ebolavirus is a hemorrhagic fever virus associated with high mortality. Although much has been learned about the viral lifecycle and pathogenesis, many questions remain about virus entry. We recently showed that binding ...
- Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteins
[作者:Goel, S; Valiyaveettil, M; Achur, RN; Goyal, A; Mattei, D; Salanti, A; Trenholme, KR; Gardiner, DL; Gowda, DC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16643-16648 , 文章类型: Article,,卷期:2010年107-38]
- Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family members mediate the adherence of parasite-infected red blood cells (IRBCs) to various host receptors. A previous study has shown that the parasite prot...
- Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism
[作者:Barsegyan, A; Mackenzie, SM; Kurose, BD; McGaugh, JL; Roozendaal, B,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16655-16660 , 文章类型: Article,,卷期:2010年107-38]
- It is well established that acute administration of adrenocortical hormones enhances the consolidation of memories of emotional experiences and, concurrently, impairs working memory. These different glucocorticoid effect...
- Axonal alpha 7 nicotinic ACh receptors modulate presynaptic NMDA receptor expression and structural plasticity of glutamatergic presynaptic boutons
[作者:Lin, H; Vicini, S; Hsu, FC; Doshi, S; Takano, H; Coulter, DA; Lynch, DR,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16661-16666 , 文章类型: Article,,卷期:2010年107-38]
- In association with NMDA receptors (NMDARs), neuronal alpha 7 nicotinic ACh receptors (nAChRs) have been implicated in neuronal plasticity as well as neurodevelopmental, neurological, and psychiatric disorders. However, ...
- Oral methylphenidate normalizes cingulate activity in cocaine addiction during a salient cognitive task
[作者:Goldstein, RZ; Woicik, PA; Maloney, T; Tomasi, D; Alia-Klein, N; Shan, JT; Honorio, J; Samaras, D; Wang, RL; Telang, F; Wang, GJ; Volkow, ND,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16667-16672 , 文章类型: Article,,卷期:2010年107-38]
- Anterior cingulate cortex (ACC) hypoactivations during cognitive demand are a hallmark deficit in drug addiction. Methylphenidate (MPH) normalizes cortical function, enhancing task salience and improving associated cogni...
- Transformation and crystallization energetics of synthetic and biogenic amorphous calcium carbonate
[作者:Radha, AV; Forbes, TZ; Killian, CE; Gilbert, PUPA; Navrotsky, A,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16438-16443 , 文章类型: Article,,卷期:2010年107-38]
- Amorphous calcium carbonate (ACC) is a metastable phase often observed during low temperature inorganic synthesis and biomineralization. ACC transforms with aging or heating into a less hydrated form, and with time cryst...
- A sensitive period for environmental regulation of eating behavior and leptin sensitivity
[作者:Mainardi, M; Scabia, G; Vottari, T; Santini, F; Pinchera, A; Maffei, L; Pizzorusso, T; Maffei, M,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:16673-16678 , 文章类型: Article,,卷期:2010年107-38]
- Western lifestyle contributes to body weight dysregulation. Leptin down-regulates food intake by modulating the activity of neural circuits in the hypothalamic arcuate nucleus (ARC), and resistance to this hormone consti...
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