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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   On the relationship between perfect matches and mismatches in Affymetrix Genechips [作者：Ferrantini, A; Carlon, E,期刊：Gene, 页码：1-6 , 文章类型： Article，,卷期：2008年422-1-2] A relationship which links the fluorescence intensity histograms for perfect match (PM) and mismatch (MM) probes in Affymetrix Genechips is derived using inputs from physical-chemistry as the Langmuir and the Nearest Nei... Metadynamic sampling of the free-energy landscapes of proteins coupled with a Monte Carlo algorithm [作者：Marini, F; Camilloni, C; Provasi, D; Broglia, RA; Tiana, G,期刊：Gene, 页码：37-40 , 文章类型： Article，,卷期：2008年422-1-2] Metadynamics is a powerful computational tool to obtain the free-energy landscape of complex systems. The Monte Carlo algorithm has proven useful to calculate thermodynamic quantities associated with simplified models of... BCL :: Align-Sequence alignment and fold recognition with a custom scoring function online [作者：Dong, E; Smith, J; Heinze, S; Alexander, N; Meiler, J,期刊：Gene, 页码：41-46 , 文章类型： Article，,卷期：2008年422-1-2] BCL::Align is a multiple sequence alignment tool that utilizes the dynamic programming method in combination with a customizable scoring function for sequence alignment and fold recognition. The scoring function is a wei... A stochastic method for the reconstruction of protein structures from one-dimensional structural profiles [作者：Wolff, K; Vendruscolo, M; Porto, M,期刊：Gene, 页码：47-51 , 文章类型： Article，,卷期：2008年422-1-2] We discuss a computational approach for reconstructing the native structures of proteins from the knowledge of a structural profile - the first eigenvector of the contact map of the native structure itself. The procedure... Physical and Chemical Foundations of Bioinformatics Methods [作者：Porto, M; Roman, HE; Vendruscolo, M,期刊：Gene, 页码：VII-VII , 文章类型： Editorial Material，,卷期：2008年422-1-2] Evolutionary conservation of protein vibrational dynamics [作者：Maguid, S; Fernandez-Alberti, S; Echave, J,期刊：Gene, 页码：7-13 , 文章类型： Article，,卷期：2008年422-1-2] The aim of the present work is to study the evolutionary divergence of vibrational protein dynamics. To this end, we used the Gaussian Network Model to perform a systematic analysis of normal mode conservation on a large... Using protein binding site prediction to improve protein docking [作者：Huang, B; Schroeder, M,期刊：Gene, 页码：14-21 , 文章类型： Article，,卷期：2008年422-1-2] Predicting protein interaction interfaces and protein complexes are two important related problems. For interface prediction, there are a number of tools, such as PPI-Pred, PPISP, PINUP, Promate, and SPPIDER, which predi... Prediction of beta-turns and beta-turn types by a novel bidirectional Elman-type recurrent neural network with multiple output layers (MOLEBRNN) [作者：Kirschner, A; Frishman, D,期刊：Gene, 页码：22-29 , 文章类型： Article，,卷期：2008年422-1-2] Prediction of beta-turns from amino acid sequences has long been recognized as an important problem in structural bioinformatics due to their frequent occurrence as well as their structural and functional significance. B... Relating sequence evolution of HIV1-protease to its underlying molecular mechanics [作者：Hamacher, K,期刊：Gene, 页码：30-36 , 文章类型： Article，,卷期：2008年422-1-2] We investigate the connection between sequence evolution of the human immunodeficiency virus (HIV) type 1 protease under neutral selection or selective pressure induced by protease inhibitors and the functional and molec...