- Channel-Mediated Tonic GABA Release from Glia
[作者:Lee, S; Yoon, BE; Berglund, K; Oh, SJ; Park, H; Shin, HS; Augustine, GJ; Lee, CJ,期刊:Science, 页码:790-796 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Synaptic inhibition is based on both tonic and phasic release of the inhibitory transmitter gamma-aminobutyric acid (GABA). Although phasic GABA release arises from Ca2+-dependent exocytosis from neurons, the mechanism o...
- Collaborative Non-Self Recognition System in S-RNase-Based Self-Incompatibility
[作者:Kubo, K; Entani, T; Takara, A; Wang, N; Fields, AM; Hua, ZH; Toyoda, M; Kawashima, S; Ando, T; Isogai, A; Kao, T; Takayama, S,期刊:Science, 页码:796-799 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Self-incompatibility in flowering plants prevents inbreeding and promotes outcrossing to generate genetic diversity. In Solanaceae, a multiallelic gene, S-locus F-box (SLF), was previously shown to encode the pollen dete...
- The Detection of a Population of Submillimeter-Bright, Strongly Lensed Galaxies
[作者:Negrello, M; Hopwood, R; De Zotti, G; Cooray, A; Verma, A; Bock, J; Frayer, DT; Gurwell, MA; Omont, A; Neri, R; Dannerbauer, H; Leeuw, LL; Barton, E; Cooke, J; Kim, S; da Cunha, E; Rodighiero, G; Cox, P; Bonfield, DG; Jarvis, MJ; Serjeant, S; Ivison, RJ; ,期刊:Science, 页码:800-804 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Gravitational lensing is a powerful astrophysical and cosmological probe and is particularly valuable at submillimeter wavelengths for the study of the statistical and individual properties of dusty star-forming galaxies...
- The Effective Fine-Structure Constant of Freestanding Graphene Measured in Graphite
[作者:Reed, JP; Uchoa, B; Joe, YI; Gan, Y; Casa, D; Fradkin, E; Abbamonte, P,期刊:Science, 页码:805-808 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Electrons in graphene behave like Dirac fermions, permitting phenomena from high-energy physics to be studied in a solid-state setting. A key question is whether or not these fermions are critically influenced by Coulomb...
- Large-Area Three-Dimensional Molecular Ordering of a Polymer Brush by One-Step Processing
[作者:Hosono, N; Kajitani, T; Fukushima, T; Ito, K; Sasaki, S; Takata, M; Aida, T,期刊:Science, 页码:808-811 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Rational molecular design and processing, enabling large-area molecular ordering, are important for creating high-performance organic materials and devices. We show that, upon one-step hot-pressing with uniaxially stretc...
- Efficient Atmospheric Cleansing of Oxidized Organic Trace Gases by Vegetation
[作者:Karl, T; Harley, P; Emmons, L; Thornton, B; Guenther, A; Basu, C; Turnipseed, A; Jardine, K,期刊:Science, 页码:816-819 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The biosphere is the major source and sink of nonmethane volatile organic compounds (VOCs) in the atmosphere. Gas-phase chemical reactions initiate the removal of these compounds from the atmosphere, which ultimately pro...
- Transient Middle Eocene Atmospheric CO2 and Temperature Variations
[作者:Bijl, PK; Houben, AJP; Schouten, S; Bohaty, SM; Sluijs, A; Reichart, GJ; Damste, JSS; Brinkhuis, H,期刊:Science, 页码:819-821 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The long-term warmth of the Eocene (similar to 56 to 34 million years ago) is commonly associated with elevated partial pressure of atmospheric carbon dioxide (pCO(2)). However, a direct relationship between the two has ...
- Mutational Robustness of Ribosomal Protein Genes
[作者:Lind, PA; Berg, OG; Andersson, DI,期刊:Science, 页码:825-827 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The distribution of fitness effects (DFE) of mutations is of fundamental importance for understanding evolutionary dynamics and complex diseases and for conserving threatened species. DFEs estimated from DNA sequences ha...
- Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein-alpha
[作者:Kraman, M; Bambrough, PJ; Arnold, JN; Roberts, EW; Magiera, L; Jones, JO; Gopinathan, A; Tuveson, DA; Fearon, DT,期刊:Science, 页码:827-830 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The stromal microenvironment of tumors, which is a mixture of hematopoietic and mesenchymal cells, suppresses immune control of tumor growth. A stromal cell type that was first identified in human cancers expresses fibro...
- Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
[作者:Wallace, BD; Wang, HW; Lane, KT; Scott, JE; Orans, J; Koo, JS; Venkatesh, M; Jobin, C; Yeh, LA; Mani, S; Redinbo, MR,期刊:Science, 页码:831-835 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The dose-limiting side effect of the common colon cancer chemotherapeutic CPT-11 is severe diarrhea caused by symbiotic bacterial beta-glucuronidases that reactivate the drug in the gut. We sought to target these enzymes...
- The Mechanism for Activation of GTP Hydrolysis on the Ribosome
[作者:Voorhees, RM; Schmeing, TM; Kelley, AC; Ramakrishnan, V,期刊:Science, 页码:835-838 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Protein synthesis requires several guanosine triphosphatase (GTPase) factors, including elongation factor Tu (EF-Tu), which delivers aminoacyl-transfer RNAs (tRNAs) to the ribosome. To understand how the ribosome trigger...
- Evolution of Yeast Noncoding RNAs Reveals an Alternative Mechanism for Widespread Intron Loss
[作者:Mitrovich, QM; Tuch, BB; De La Vega, FM; Guthrie, C; Johnson, AD,期刊:Science, 页码:838-841 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- The evolutionary forces responsible for intron loss are unresolved. Whereas research has focused on protein-coding genes, here we analyze noncoding small nucleolar RNA ( snoRNA) genes in which introns, rather than exons,...
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
[作者:Ginhoux, F; Greter, M; Leboeuf, M; Nandi, S; See, P; Gokhan, S; Mehler, MF; Conway, SJ; Ng, LG; Stanley, ER; Samokhvalov, IM; Merad, M,期刊:Science, 页码:841-845 , 文章类型: 期刊论文,,卷期:2010年330-6005]
- Microglia are the resident macrophages of the central nervous system and are associated with the pathogenesis of many neurodegenerative and brain inflammatory diseases; however, the origin of adult microglia remains cont...
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