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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   The biology and chemistry of antifungal agents: A review [作者：KATHIRAVAN MUTHU K; SALAKE AMOL B; CHOTHE APARNA S; DUDHE PRASHIK B; WATODE RAHUL P; MUKTA MAHESHWAR S; GADHWE SANDEEP,期刊：Bioorganic & Medicinal Chemistry, 页码：5678-5698 , 文章类型： Review，,卷期：2012年20-19] In recent years their has been an increased use of antifungal agents and has resulted in the development of resistance to drugs. Currently, use of standard antifungal therapies can be limited because of toxicity, low eff... Possible conformation of amphotericin B dimer in membrane-bound assembly as deduced from solid-state NMR [作者：UMEGAWA YUICHI; ADACHI TAKESHI; MATSUMORI NOBUAKI; MURATA MICHIO,期刊：Bioorganic & Medicinal Chemistry, 页码：5699-5704 , 文章类型： Article，,卷期：2012年20-19] Aiming for structural analysis of amphotericin B (AmB) ion-channel assemblies in membrane, a covalent dimer was synthesized between C-13-labled AmB methyl ester and F-19-labled AmB. The dimer showed slightly weaker but s... Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrro lidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes [作者：YOSHIDA TOMOHIRO; AKAHOSHI FUMIHIKO; SAKASHITA HIROSHI; KITAJIMA HIROSHI; NAKAMURA MITSUHARU; SONDA SHUJI; TAKEUCHI MASAHIRO; TANAKA YOSHIHITO; UEDA NAOKO; SEKIGUCHI SUMIE; ISHIGE TAKAYUKI; SHIMA KYOKO; NABENO MIKA; ABE YUJI; ANABUKI JUN; SOEJIMA AKI; YOSHIDA KUMIKO; TAKASHINA YOKO; ISHII SHINICHI; KIUCHI SATOKO; FUKUDA SAYAKA; TSUTSUMIUCHI REIKO; KOSAKA KEIGO; MUROZONO TAKAHIRO; NAKAMARU YOSHINOBU; UTSUMI HIROYUKI; MASUTOMI NAOYA; KISHIDA HIROYUKI; MIYAGUCHI IKUKO; HAYASHI YOSHIHARU,期刊：Bioorganic & Medicinal Chemistry, 页码：5705-5719 , 文章类型： Article，,卷期：2012年20-19] Dipeptidyl peptidase IV (DPP-4) inhibition is suitable mechanism for once daily oral dosing regimen because of its low risk of hypoglycemia. We explored linked bicyclic heteroarylpiperazines substituted at the gamma-posi... Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers [作者：KIM HYOUNG RAE; KIM JAE JIN; PARK JUNG JAE; LEE SANG HYUP,期刊：Bioorganic & Medicinal Chemistry, 页码：5720-5729 , 文章类型： Article，,卷期：2012年20-19] We report the synthetic and mechanistic studies on a new cyclic disulfide mitomycin dimer, 7-N,7'-N'-(1 '',2 ''-dithiolanyl-3 '',5 ''-dimethylenyl) bismitomycin C (8), and a diol mitomycin dimer, 7-N, 7'-N'-(200,4 ''-dih... Evaluation of dimerization-inhibitory activities of cyclic peptides containing a beta-hairpin loop sequence of the EGF receptor [作者：MIZUGUCHI TAKAAKI; OHARA NAHO; IIDA MIKA; NINOMIYA RYUNOSUKE; WADA SHINJI; KISO YOSHIAKI; SAITO KAZUKI; AKAJI KENICHI,期刊：Bioorganic & Medicinal Chemistry, 页码：5730-5737 , 文章类型： Article，,卷期：2012年20-19] Structure-activity relationships of cyclic peptides mimicking the beta-hairpin structure of the 'dimerization arm' at residues 242-259 of the EGF receptor are examined. Cyclic peptides containing the arm head of the beta... Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold [作者：CHENG XIANCHAO; WANG RUNLING; DONG ZHENKE; LI JING; LI YAOYUAN; LI RONGRONG,期刊：Bioorganic & Medicinal Chemistry, 页码：5738-5744 , 文章类型： Article，,卷期：2012年20-19] A series of novel L-tyrosine derivatives were designed, synthesized and assayed for their inhibitory activities on matrix metalloproteinase 2 (MMP-2) and histone deacetylase 8 (HDAC-8). The results showed that these L-ty... Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone [作者：HAYAKAWA ICHIRO; IKEDO AKIYUKI; CHINEN TAKUMI; USUI TAKEO; KIGOSHI HIDEO,期刊：Bioorganic & Medicinal Chemistry, 页码：5745-5756 , 文章类型： Article，,卷期：2012年20-19] Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O-7-modified glaziovianin A showed strong cytotoxicity against HeLa S-3 cells. Compared to g... Novel interleukin-5 inhibitors based on hydroxyethylaminomethyl-4H-chromen-4-one scaffold [作者：JOO CHEONIK; VENKATESWARARAO EEDA; LEE KICHEUL; SHARMA VINAY K; KYUNG MINSIK; KIM YOUNGSOO; JUNG SANGHUN,期刊：Bioorganic & Medicinal Chemistry, 页码：5757-5762 , 文章类型： Article，,卷期：2012年20-19] Hydroxyethylaminomethyl-4H-chromenones were previously discovered as fairly strong IL-5 inhibitor. For determination of detail structure activity relationship, N-substituted hydroxyethylaminomethyl-chromenones 4a-n were ... Synthesis and evaluation of novel heteroaromatic substrates of GABA aminotransferase [作者：HAWKER DUSTIN D; SILVERMAN RICHARD B,期刊：Bioorganic & Medicinal Chemistry, 页码：5763-5773 , 文章类型： Article，,卷期：2012年20-19] Two principal neurotransmitters are involved in the regulation of mammalian neuronal activity, namely, gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, and L-glutamic acid, an excitatory neurotransmitter. ... Synthesis of novel ursolic acid heterocyclic derivatives with improved abilities of antiproliferation and induction of p53, p21(waf1) and NOXA in pancreatic cancer cells [作者：LEAL ANA S; WANG RUI; SALVADOR JORGE A R; JING YONGKUI,期刊：Bioorganic & Medicinal Chemistry, 页码：5774-5786 , 文章类型： Article，,卷期：2012年20-19] A series of new heterocyclic derivatives of ursolic acid 1 were synthesized and evaluated for their anti-proliferative activity against AsPC-1 pancreatic cancer cells. Compounds 24-32, with an alpha,beta unsaturated keto... Synthesis and structure-activity relationship of a novel class of 15-membered macrolide antibiotics known as '11a-azalides' [作者：SUGIMOTO TOMOHIRO; TANIKAWA TETSUYA; SUZUKI KEIKO; YAMASAKI YUKIKO,期刊：Bioorganic & Medicinal Chemistry, 页码：5787-5801 , 文章类型： Article，,卷期：2012年20-19] Macrolide antibiotics are widely prescribed for the treatment of respiratory tract infections; however, the increasing prevalence of macrolide-resistant pathogens is a public health concern. Therefore, the development of... Phosphoramidate derivatives of acyclovir: Synthesis and antiviral activity in HIV-1 and HSV-1 models in vitro [作者：ZAKIROVA NATALIA F; SHIPITSYN ALEXANDER V; JASKO MAXIM V; PROKOFJEVA MARIA M; ANDRONOVA VALERIA L; GALEGOV GEORGIY A; PRASSOLOV VLADIMIR S; KOCHETKOV SERGEY N,期刊：Bioorganic & Medicinal Chemistry, 页码：5802-5809 , 文章类型： Article，,卷期：2012年20-19] The antiviral activity against HIV and HSV and the chemical stability of ACV phosphoramidate derivatives were studied. The phosphoramidates of ACV demonstrated moderate activity. The best compound appeared to be 9-(2-hyd... Synthesis of quinolinomorphinan derivatives as highly selective delta opioid receptor ligands [作者：IDA YOSHIHIRO; MATSUBARA AYAKA; NEMOTO TORU; SAITO MANABU; HIRAYAMA SHIGETO; FUJII HIDEAKI; NAGASE HIROSHI,期刊：Bioorganic & Medicinal Chemistry, 页码：5810-5831 , 文章类型： Article，,卷期：2012年20-19] We have reported previously the novel delta opioid agonist KNT-127 which showed high affinity and selectivity for the delta receptor. Moreover, the analgesic effect of subcutaneously administered KNT-127 was more potent ... Hybrid stereoisomers of a compact molecular probe based on a jasmonic acid glucoside: Syntheses and biological evaluations [作者：UEDA MINORU; YANG GANGQIANG; ISHIMARU YASUHIRO; ITABASHI TETSUYA; TAMURA SATORU; KIYOTA HIROMASA; KUWAHARA SHIGEFUMI; INOMATA SHO; SHOJI MITSURU; SUGAI TAKESHI,期刊：Bioorganic & Medicinal Chemistry, 页码：5832-5843 , 文章类型： Article，,卷期：2012年20-19] 12-O-beta-D-glucopyranosyl jasmonic acid (JAG) shows unique biological activities, including leaf-closing of Samanea saman. It is expected that the mode of action for such regulation is distinct from that of other jasmon... Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid beta-protein [作者：MIYAMAE YUSAKU; KURISU MANAMI; MURAKAMI KAZUMA; HAN JUNKYU; ISODA HIROKO; IRIE KAZUHIRO; SHIGEMORI HIDEYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：5844-5849 , 文章类型： Article，,卷期：2012年20-19] Alzheimer's disease (AD), a neurodegenerative disorder, is characterized by aggregation of 42-mer amyloid beta-protein (A beta 42). A beta 42 aggregates through beta-sheet formation and induces cytotoxicity against neuro... Antibacterial activities of Groebke-Blackburn-Bienayme-derived imidazo[1,2-a]pyridin-3-amines [作者：SHUKLA NIKUNJ M; SALUNKE DEEPAK B; YOO EUNA; MUTZ COLE A; BALAKRISHNA RAJALAKSHMI; DAVID SUNIL A,期刊：Bioorganic & Medicinal Chemistry, 页码：5850-5863 , 文章类型： Article，,卷期：2012年20-19] We sought to explore the imidazo[1,2-a]pyridin-3-amines for TLR7 (or 8)-modulatory activities. This chemotype, readily accessed via the Groebke-Blackburn-Bienayme multi-component reaction, resulted in compounds that were...