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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共24条记录   Morita-Baylis-Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs [作者：LIMAJUNIOR CLAUDIO G; VASCONCELLOS MARIO L A A,期刊：Bioorganic & Medicinal Chemistry, 页码：3954-3971 , 文章类型： Review，,卷期：2012年20-13] This review aims to present by the first time the Morita-Baylis-Hillman adducts (MBHA) as a new class of bioactive compounds and highlight its potentialities to the discovery of new cheaper and efficient drugs. Now, most... Synthesis of tocopheryl succinate phospholipid conjugates and monitoring of phospholipase A(2) activity [作者：PEDERSEN PALLE J; VIART HELENE MF; MELANDER FREDRIK; ANDRESEN THOMAS L; MADSEN ROBERT; CLAUSEN MADS H,期刊：Bioorganic & Medicinal Chemistry, 页码：3972-3978 , 文章类型： Article，,卷期：2012年20-13] Tocopheryl succinates (TOSs) are, in contrast to tocopherols, highly cytotoxic against many cancer cells. In this study the enzyme activity of secretory phospholipase A(2) towards various succinate-phospholipid conjugate... Thiol-reactive compounds from garlic inhibit the epithelial sodium channel (ENaC) [作者：KRUMM PATRICK; GIRALDEZ TERESA; ALVAREZ DE LA ROSA DIEGO; CLAUSS WOLFGANG G; FRONIUS MARTIN; ALTHAUS MIKE,期刊：Bioorganic & Medicinal Chemistry, 页码：3979-3984 , 文章类型： Article，,卷期：2012年20-13] The epithelial sodium channel (ENaC) is a key factor in the transepithelial movement of sodium, and consequently salt and water homeostasis in various organs. Dysregulated activity of ENaC is associated with human diseas... Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen [作者：MIYANO YUKA; TSUKUDA SENKO; SAKIMOTO IPPEI; TAKEUCHI RYO; SHIMURA SATOMI; TAKAHASHI NORIYUKI; KUSAYANAGI TOMOE; TAKAKUSAGI YOICHI; OKADO MAMI; MATSUMOTO YUKI; TAKAKUSAGI KAORI; TAKEUCHI TOSHIFUMI; KAMISUKI SHINJI; NAKAZAKI ATSUO; OHTA KEISUKE; MIURA MASAHIKO; KURAMOCHI KOUJI; MIZUSHINA YOSHIYUKI; KOBAYASHI SUSUMU; SUGAWARA FUMIO; SAKAGUCHI KENGO,期刊：Bioorganic & Medicinal Chemistry, 页码：3985-3990 , 文章类型： Article，,卷期：2012年20-13] Perfluorooctane sulfonate (PFOS) is a pollutant widely found throughout nature and is toxic to animals. We created a PFOS analogue on a polyethylene glycol polyacrylamide copolymer and isolated peptides that preferential... The cruciferous phytoalexins rapalexin A, brussalexin A and erucalexin: Chemistry and metabolism in Leptosphaeria maculans [作者：PEDRAS M SOLEDADE C; SARMAMAMILLAPALLE VIJAY K,期刊：Bioorganic & Medicinal Chemistry, 页码：3991-3996 , 文章类型： Article，,卷期：2012年20-13] The interactions of the cruciferous phytoalexins rapalexin A (1), brussalexin A (2) and erucalexin (3) with the fungal plant pathogen Leptosphaeria maculans were analyzed and their inhibitory activities against this path... Design and synthesis of prodrugs of the rat selective toxicant norbormide [作者：RENNISON DAVID; LAITA OLIVIA; BOVA SERGIO; CAVALLI MAURIZIO; HOPKINS BRIAN; LINTHICUM DARWIN S; BRIMBLE MARGARET A,期刊：Bioorganic & Medicinal Chemistry, 页码：3997-4011 , 文章类型： Article，,卷期：2012年20-13] Norbormide [5-(alpha-hydroxy-alpha-2-pyridylbenzyl)-7-(alpha-2-pyridylbenzylidene)-5-norbornene-2,3-dicarboximide] (NRB), an existing but infrequently used rodenticide, is known to be uniquely toxic to rats but relativel... Effects of chemical modification of sphingomyelin ammonium group on formation of liquid-ordered phase [作者：GORETTA SARAH A; KINOSHITA MASANAO; MORI SHOKO; TSUCHIKAWA HIROSHI; MATSUMORI NOBUAKI; MURATA MICHIO,期刊：Bioorganic & Medicinal Chemistry, 页码：4012-4019 , 文章类型： Article，,卷期：2012年20-13] Sphingomyelin (SM) and cholesterol form microdomains called lipid rafts in cellular membranes. To develop a versatile fluorescent lipid probe, chemical modifications to both the hydrophobic and hydrophilic portions of SM... Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens [作者：SHI QIAN; WADA KOJI; OHKOSHI EMIKA; LIN LI; HUANG RONG; MORRISNATSCHKE SUSAN L; GOTO MASUO; LEE KUOHSIUNG,期刊：Bioorganic & Medicinal Chemistry, 页码：4020-4031 , 文章类型： Article，,卷期：2012年20-13] In our continuing study of curcumin analogs as potential anti-prostate cancer drug candidates, 15 new curcumin analogs were designed, synthesized and evaluated for cytotoxicity against two human prostate cancer cell line... Photodynamic inactivation of Candida albicans using bridged polysilsesquioxane films doped with porphyrin [作者：GABRIELA ALVAREZ M; LORENA GOMEZ M; JIMERA MORA S; ELISA MILANESIO M; DURANTINI EDGARDO N,期刊：Bioorganic & Medicinal Chemistry, 页码：4032-4039 , 文章类型： Article，,卷期：2012年20-13] Novel photoactive bridged polysilsesquioxane films were prepared by doped with a porphyrin derivative. The films were formed by acid-catalyzed polycondensation reaction of a precursor of a bridged silsesquioxane, based o... Influence of ligand denticity on the properties of novel Tc-99m(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue [作者：FERNANDEZ SOLEDAD; GIGLIO JAVIER; REY ANA M; CERECETTO HUGO,期刊：Bioorganic & Medicinal Chemistry, 页码：4040-4048 , 文章类型： Article，,卷期：2012年20-13] An important issue in the development of metal-based radiopharmaceuticals is the selection of the labelling strategy in order to couple the metal to the pharmacophore without losing the biological activity. With the aim ... Chlorine atom substitution influences radical scavenging activity of 6-chromanol [作者：INAMI KEIKO; IIZUKA YUKO; FURUKAWA MIYUKI; NAKANISHI IKUO; OHKUBO KEI; FUKUHARA KIYOSHI; FUKUZUMI SHUNICHI; MOCHIZUKI MASATAKA,期刊：Bioorganic & Medicinal Chemistry, 页码：4049-4055 , 文章类型： Article，,卷期：2012年20-13] Synthetic 6-chromanol derivatives were prepared with several chlorine substitutions, which conferred both electron-withdrawing inductive effects and electron-donating resonance effects. A trichlorinated compound (2), a d... Polymer conjugates of acridine-type anticancer drugs with pH-controlled activation [作者：SEDLACEK ONDREJ; HRUBY MARTIN; STUDENOVSKY MARTIN; VETVICKA DAVID; SVOBODA JAN; KANKOVA DANA; KOVAR JAN; ULBRICH KAREL,期刊：Bioorganic & Medicinal Chemistry, 页码：4056-4063 , 文章类型： Article，,卷期：2012年20-13] Acridines are potent DNA-intercalating anticancer agents with high in vivo anticancer effectiveness, but also severe side effects. We synthesized five 9-anilinoacridine-type drugs and their conjugates with biocompatible ... Substrate analog studies of the omega-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1 [作者：JOHNSTON JONATHAN B; SINGH ARTI A; CLARY ANAELLE A; CHEN CHIUNGKUAN; HAYES PATRICIA Y; CHOW SHARON; DE VOSS JAMES J; DE MONTELLANO PAUL R ORTIZ,期刊：Bioorganic & Medicinal Chemistry, 页码：4064-4081 , 文章类型： Article，,卷期：2012年20-13] We report the synthesis and evaluation of a series of cholesterol side-chain analogs as mechanistic probes of three important Mycobacterium tuberculosis cytochrome P450 enzymes that selectively oxidize the omega-position... Beta-carboline alkaloids derived from the ascidian Synoicum sp. [作者：WON TAE HYUNG; JEON JUEUN; LEE SOHYOUNG; RHO BOON JO; OH KIBONG; SHIN JONGHEON,期刊：Bioorganic & Medicinal Chemistry, 页码：4082-4087 , 文章类型： Article，,卷期：2012年20-13] Six beta-carboline alkaloids (1-6) of the eudistomin Y class were isolated from the Korean ascidian Synoicum sp. These compounds were chemically converted to a known compound, eudistomin Y-1 (7) and six new derivatives, ... Discovery of novel 5-(ethyl or hydroxymethyl) analogs of 2 '-'up' fluoro (or hydroxyl) pyrimidine nucleosides as a new class of Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium avium inhibitors [作者：SHAKYA NEERAJ; SRIVASTAV NAVEEN C; BHAVANAM SUDHA; TSE CHRIS; DESROCHES NANCY; AGRAWAL BABITA; KUNIMOTO DENNIS Y; KUMAR RAKESH,期刊：Bioorganic & Medicinal Chemistry, 页码：4088-4097 , 文章类型： Article，,卷期：2012年20-13] Discovery of novel antimycobacterial compounds that work on distinctive targets and by diverse mechanisms of action is urgently required for the treatment of mycobacterial infections due to the emerging global health thr... Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides [作者：RAHMAN S M ABDUR; BABA TAKESHI; KODAMA TETSUYA; ISLAM MD ARIFUL; OBIKA SATOSHI,期刊：Bioorganic & Medicinal Chemistry, 页码：4098-4102 , 文章类型： Article，,卷期：2012年20-13] Various stereochemically pure cationic phosphorothioate oligonucleotides bearing aminoalkyl moieties were synthesized, and their duplex-forming ability against single-stranded DNA (ssDNA), single-stranded RNA (ssRNA) and...