- Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells
[作者:Ross, MF; Prime, TA; Abakumova, I; James, AM; Porteous, CM; Smith, RAJ; Murphy, MP,期刊:Biochemical Journal, 页码:633-645 , 文章类型: Article,,卷期:2008年411-3]
- Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to modify and probe mitochondria in cells and in vivo. However, it ...
- Akt substrate TBCM regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes
[作者:Zhou, QL; Jiang, DY; Holik, J; Chawla, A; Hagan, GN; Leszyk, J; Czech, MP,期刊:Biochemical Journal, 页码:647-655 , 文章类型: Article,,卷期:2008年411-3]
- Multiple studies have suggested that the protein kinase Akt/PKB (protein kinase B) is required for insulin-stimulated glucose transport in skeletal muscle and adipose cells. In an attempt to understand links between Akt ...
- Proteasome-dependent degradation of alpha-catenin is regulated by interaction with ARMc8 alpha
[作者:Suzuki, T; Ueda, A; Kobayashi, N; Yang, J; Tomaru, K; Yamamoto, M; Takeno, M; Ishigatsubo, Y,期刊:Biochemical Journal, 页码:581-591 , 文章类型: Article,,卷期:2008年411-3]
- ARMc8 (armadillo-repeat-containing protein 8) is a key component of the CTLH (C-terminal to lissencephaly type-1-like homology motif) complex in mammalian cells. This complex is well conserved in Saccharomyces cerevisiae...
- Nitric oxide mediates NMDA-induced persistent inhibition of protein synthesis through dephosphorylation of eukaryotic initiation factor 4E-binding protein 1 and eukaryotic initiation factor 4G proteolysis
[作者:Petegnief, V; Font-Nieves, M; Martin, ME; Salinas, M; Planas, AM,期刊:Biochemical Journal, 页码:667-677 , 文章类型: Article,,卷期:2008年411-3]
- Cerebral ischaemia causes long-lasting protein synthesis inhibition that is believed to contribute to brain damage. Energy depletion promotes translation inhibition during ischaemia, and the phosphorylation of eIF (eukar...
- Genetic disruption of calpain correlates with loss of membrane blebbing and differential expression of RhoGDI-1, cofilin and tropomyosin
[作者:Larsen, AK; Lametsch, R; Elce, JS; Larsen, JK; Thomsen, B; Larsen, MR; Lawson, MA; Greer, PA; Ertbjerg, P,期刊:Biochemical Journal, 页码:657-666 , 文章类型: Article,,卷期:2008年411-3]
- Dynamic regulation of the actin cytoskeleton is important for cell motility, spreading and the formation of membrane surface extensions such as lamellipodia, ruffles and blebs. The ubiquitous calpains contribute to integ...
- Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom
[作者:Vassilevski, AA; Kozlov, SA; Samsonova, OV; Egorova, NS; Karpunin, DV; Pluzhnikov, KA; Feofanov, AV; Grishin, EV,期刊:Biochemical Journal, 页码:687-696 , 文章类型: Article,,卷期:2008年411-3]
- Eight linear cationic peptides with cytolytic and insecticidal activity, designated cyto-insectotoxins (CITs), were identified in Lachesana tarabaevi spider venom. The peptides showed antibiotic activity towards Gram-pos...
- Computational and experimental studies on the catalytic mechanism of biliverdin-IX beta reductase
[作者:Smith, LJ; Browne, S; Mulholland, AJ; Mantle, TJ,期刊:Biochemical Journal, 页码:475-484 , 文章类型: Article,,卷期:2008年411-3]
- BVR-B (biliverdin-IX beta reductase) also known as FR (flavin reductase) is a promiscuous enzyme catalysing the pyridine-nucleotide-dependent reduction of a variety of flavins, biliverdins, PQQ (pyrroloquinoline quinone)...
- The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42
[作者:Upadhyay, A; Wu, HL; Williams, C; Field, T; Galyov, EE; van den Elsen, JMH; Bagby, S,期刊:Biochemical Journal, 页码:485-493 , 文章类型: Article,,卷期:2008年411-3]
- BopE is a type III secreted protein from Burkholderia pseudomallei, the aetiological agent of melioidosis, a severe emerging infection. BopE is a GEF (guanine-nucleotide-exchange factor) for the Rho GTPases Cdc42 (cell d...
- Specific transmembrane segments are selectively delayed at the ER translocon during opsin biogenesis
[作者:Ismail, N; Crawshaw, SG; Cross, BCS; Haagsma, AC; High, S,期刊:Biochemical Journal, 页码:495-506 , 文章类型: Article,,卷期:2008年411-3]
- A site-specific cross-linking approach was used to study the integration of TM (transmembrane) segments 4-7 of the polytopic membrane protein, opsin, at the ER (endoplasmic reticulum). We found that although TM4 exits th...
- Endosomal NADPH oxidase regulates c-Src activation following hypoxia/reoxygenation injury
[作者:Li, Q; Zhang, W; Marden, JJ; Banfi, B; Engelhardt, JF,期刊:Biochemical Journal, 页码:531-541 , 文章类型: Article,,卷期:2008年411-3]
- c-Src has been shown to activate NF-kappa B (nuclear factor kappa B) following H/R (hypoxia/reoxygenation) by acting as a redox-dependent I kappa B alpha (inhibitory kappa B) tyrosine kinase. In the present study, we hav...
- A critical role in structure-specific DNA binding for the acetylatable lysine residues in HMGB1
[作者:Assenberg, R; Webb, M; Connolly, E; Stott, K; Watson, M; Hobbs, J; Thomas, JO,期刊:Biochemical Journal, 页码:553-561 , 文章类型: Article,,卷期:2008年411-3]
- The structure-specific DNA-binding protein HMGB1 (high-mobility group protein B1) which comprises two tandem HMG boxes (A and B) and an acidic C-terminal tail, is acetylated in vivo at Lys(2) and Lys(11) in the A box. Mu...
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