- Chloroquine Transport in Plasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe
[作者:Cabrera, M; Natarajan, J; Paguio, MF; Wolf, C; Urbach, JS; Roepe, PD,期刊:Biochemistry, 页码:9471-9481 , 文章类型: Article,,卷期:2009年48-40]
- Several models for how amino acid substitutions in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) confer resistance to chloroquine (CQ) and other antimalarial drugs have been proposed. Distinguishin...
- Chloroquine Transport in Plasmodium falciparum. 2. Analysis of PfCRT-Mediated Drug Transport Using Proteoliposomes and a Fluorescent Chloroquine Probe
[作者:Paguio, MF; Cabrera, M; Roepe, PD,期刊:Biochemistry, 页码:9482-9491 , 文章类型: Article,,卷期:2009年48-40]
- Mutations in the PfCRT protein cause chloroquine resistance (CQR), and earlier studies from our laboratory using plasma membrane inside-out vesicles (ISOV) prepared from yeast expressing recombinant PfCRT [Zhang, H., et ...
- Mechanism of Cadmium-Mediated Inhibition of Msh2-Msh6 Function in DNA Mismatch Repair
[作者:Wieland, M; Levin, MK; Hingorani, KS; Biro, FN; Hingorani, MM,期刊:Biochemistry, 页码:9492-9502 , 文章类型: Article,,卷期:2009年48-40]
- The observation that Cadmium (Cd2+) inhibits Msh2-Msh6, which is responsible for identifying base pair mismatches and other discrepancies in DNA, has led to the proposal that selective targeting of this protein and conse...
- Acid Residues in the Transmembrane Helices of the Na+-Pumping NADH:Quinone Oxidoreductase from Vibrio cholerae Involved in Sodium Translocation
[作者:Juarez, O; Athearn, K; Gillespie, P; Barquera, B,期刊:Biochemistry, 页码:9516-9524 , 文章类型: Article,,卷期:2009年48-40]
- Vibrio cholerae and many other marine. and pathogenic bacteria possess a unique respiratory complex, the Na+-pumping NADH:quinone oxidoreductase (Na+-NQR), which pumps Na+ across the cell membrane using the energy releas...
- Plasmodium falciparum Ferredoxin-NADP(+) Reductase His286 Plays a Dual Role in NADP(H) Binding and Catalysis
[作者:Crobu, D; Canevari, G; Milani, M; Pandini, V; Vanoni, MA; Bolognesi, M; Zanetti, G; Aliverti, A,期刊:Biochemistry, 页码:9525-9533 , 文章类型: Article,,卷期:2009年48-40]
- The NADP-binding site of Plasmodium falciparum ferredoxin-NADP+ reductase contains two basic residues, His286 and Lys249, conserved within the Plasmodium genus, but not in other plant-type homologues. Previous crystal st...
- Analysis of the Interaction of BCL9 with beta-Catenin and Development of Fluorescence Polarization and Surface Plasmon Resonance Binding Assays for this Interaction
[作者:Kawamoto, SA; Thompson, AD; Coleska, A; Nikolovska-Coleska, Z; Yi, H; Wang, SM,期刊:Biochemistry, 页码:9534-9541 , 文章类型: Article,,卷期:2009年48-40]
- The transcriptional activator beta-catenin is the primary mediator of the canonical Writ signaling pathway and is frequently upregulated in many types of human cancer. Recent studies have suggested that the interaction o...
- Factors That Affect Oxygen Activation and Coupling of the Two Redox Cycles in the Aromatization Reaction Catalyzed by NikD, an Unusual Amino Acid Oxidase
[作者:Kommoju, PR; Bruckner, RC; Ferreira, P; Carrell, CJ; Mathews, FS; Jorns, MS,期刊:Biochemistry, 页码:9542-9555 , 文章类型: Article,,卷期:2009年48-40]
- NikD is a flavoprotein oxidase that catalyzes the oxidation of piperideine-2-carboxylate (P2C) to picolinate in a remarkable aromatization reaction comprising two redox cycles and at least one isomerization step. Tyr258 ...
- Biophysical Characterization of the Iron in Mitochondria from Atm1p-Depleted Saccharomyces cerevisiae
[作者:Miao, R; Kim, H; Koppolu, UMK; Ellis, EA; Scott, RA; Lindahl, PA,期刊:Biochemistry, 页码:9556-9568 , 文章类型: Article,,卷期:2009年48-40]
- Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export an unknown species into the cytosol and is involved in cellular iron metabolism. Depletion or deletion of Atm1p causes Fe ...
- The Yeast Iron Regulatory Proteins Grx3/4 and Fra2 Form Heterodimeric Complexes Containing a [2Fe-2S] Cluster with Cysteinyl and Histidyl Ligation
[作者:Li, HR; Mapolelo, DT; Dingra, NN; Naik, SG; Lees, NS; Hoffman, BM; Riggs-Gelasco, PJ; Huynh, BH; Johnson, MK; Outten, CE,期刊:Biochemistry, 页码:9569-9581 , 文章类型: Article,,卷期:2009年48-40]
- The transcription of iron uptake and storage genes in Saccharomyces cerevisiae is primarily regulated by the transcription factor Aft1. Nucleocytoplasmic shuttling of Aft1 is dependent upon mitochondrial Fe-S cluster bio...
- N-Terminal Acetylation of the Neuronal Protein SNAP-25 Is Revealed by the SMI81 Monoclonal Antibody
[作者:Connell, E; Darios, F; Peak-Chew, S; Soloviev, M; Davletov, B,期刊:Biochemistry, 页码:9582-9589 , 文章类型: Article,,卷期:2009年48-40]
- The monoclonal antibody SMI81 binds SNAP-25, a major player in neurotransmitter release, with high affinity and has previously been used to follow changes in the levels of this protein in neuropsychiatric disorders. We r...
- Molecular Basis of Substrate Promiscuity for the SAM-Dependent O-Methyltransferase NcsB1, Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic Neocarzinostatin
[作者:Cooke, HA; Guenther, EL; Luo, YG; Shen, B; Bruner, SD,期刊:Biochemistry, 页码:9590-9598 , 文章类型: Article,,卷期:2009年48-40]
- The small molecule component of chromoprotein enediyne antitumor antibiotics is biosynthesized through a convergent route, incorporating amino acid, polyketide, and carbohydrate building blocks around a central enediyne ...
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