- Impact of albumin on drug delivery - New applications on the horizon
[作者:Elsadek, B; Kratz, F,期刊:Journal of controlled release, 页码:4-28 , 文章类型: Review,,卷期:2012年157-1]
- Over the past decades, albumin has emerged as a versatile carrier for therapeutic and diagnostic agents, primarily for diagnosing and treating diabetes, cancer, rheumatoid arthritis and infectious diseases. Market approv...
- A novel method for the direct fabrication of growth factor-loaded microspheres within porous nondegradable hydrogels: Controlled release for cartilage tissue engineering
[作者:Spiller, KL; Liu, Y; Holloway, JL; Maher, SA; Cao, YL; Liu, W; Zhou, GD; Lowman, AM,期刊:Journal of controlled release, 页码:39-45 , 文章类型: Article,,卷期:2012年157-1]
- Because of similar mechanical properties to native cartilage, synthetic hydrogels based on poly(vinyl alcohol) (PVA) have been proposed for replacement of damaged articular cartilage, but they suffer from a complete lack...
- Heparin-triggered release of camouflaged tissue plasminogen activator for targeted thrombolysis
[作者:Absar, S; Choi, S; Yang, VC; Kwon, YM,期刊:Journal of controlled release, 页码:46-54 , 文章类型: Article,,卷期:2012年157-1]
- A targetable, heparin-triggered release system for tissue plasminogen activator (tPA) was designed to prevent the excessive 'lytic' state associated with the current tPA therapy for acute thrombotic conditions, such as m...
- PEGylated poly(ethylene imine) copolymer-delivered siRNA inhibits HIV replication in vitro
[作者:Weber, ND; Merkel, OM; Kissel, T; Munoz-Fernandez, MA,期刊:Journal of controlled release, 页码:55-63 , 文章类型: Article,,卷期:2012年157-1]
- RNA interference is increasingly being utilized for the specific targeting and down-regulation of disease-causing genes, including targeting viral infections such as HIV. T lymphocytes, the primary target for HIV, are ve...
- Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation
[作者:Boylan, NJ; Suk, JS; Lai, SK; Jelinek, R; Boyle, MP; Cooper, MJ; Hanes, J,期刊:Journal of controlled release, 页码:72-79 , 文章类型: Article,,卷期:2012年157-1]
- Highly compacted DNA nanoparticles, composed of single molecules of plasmid DNA compacted with block copolymers of poly-L-lysine and 10 kDa polyethylene glycol (CK(30)PEG(10k)), mediate effective gene delivery to the bra...
- Transcutaneous DNA immunization following waxing-based hair depilation
[作者:Sloat, BR; Kiguchi, K; Xiao, G; DiGiovanni, J; Maury, W; Cui, ZR,期刊:Journal of controlled release, 页码:94-102 , 文章类型: Article,,卷期:2012年157-1]
- Transcutaneous DNA immunization is an attractive immunization approach. Previously, we reported that transcutaneous immunization by applying plasmid DNA onto a skin area wherein the hair follicles had been induced into g...
- Micellization of cisplatin (NC-6004) reduces its ototoxicity in guinea pigs
[作者:Baba, M; Matsumoto, Y; Kashio, A; Cabral, H; Nishiyama, N; Kataoka, K; Yamasoba, T,期刊:Journal of controlled release, 页码:112-117 , 文章类型: Article,,卷期:2012年157-1]
- Nanocarriers potentially reduce or prevent chemotherapy-induced side effects, facilitating the translation of nanocarrier formulation into the clinic. To date, organ-specific toxicity by nanocarriers remains to be clarif...
- LyP-1-conjugated PEGylated liposomes: A carrier system for targeted therapy of lymphatic metastatic tumor
[作者:Yan, ZQ; Wang, F; Wen, ZY; Zhan, CY; Feng, LL; Liu, Y; Wei, XL; Xie, C; Lu, WY,期刊:Journal of controlled release, 页码:118-125 , 文章类型: Article,,卷期:2012年157-1]
- The application of liposomes in targeted therapy of lymphatic metastatic tumors has been hampered by the low uptake rate of liposome by metastatic lymph nodes. In this report, LyP-1, a peptide that can specifically bind ...
- Coiled-coil based drug-free macromolecular therapeutics: In vivo efficacy
[作者:Wu, KS; Yang, JY; Liu, JH; Kopecek, J,期刊:Journal of controlled release, 页码:126-131 , 文章类型: Article,,卷期:2012年157-1]
- We evaluated a new concept in cancer therapy, coiled-coil mediated induction of apoptosis in Raji B cells, for treatment of human B-cell lymphoma in a preclinical animal model. The system is composed of a pair of complem...
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