个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共22条记录   Face-to-Face, Pak-to-Pak [作者：Malecke, KA; Peterson, JR,期刊：Structure, 页码：1723-1724 , 文章类型： Editorial Material，,卷期：2011年19-12] Biochemical and structural studies of p21-activated kinase 1 (Pak1) by Wang and colleagues in this issue of Structure reveal the structural basis for Pak1 trans-autophosphorylation of the activation loop, a critical step... Progress at Last [作者：Elber, R,期刊：Structure, 页码：1725-1725 , 文章类型： Editorial Material，,卷期：2011年19-12] Refinement of protein structures from a correct topology to atomically detailed resolution has proven remarkably difficult. Jian et al. (in this issue of Structure) illustrate a significant advance in this task by carefu... Phosphorylation at the Interface [作者：Davis, FP,期刊：Structure, 页码：1726-1727 , 文章类型： Editorial Material，,卷期：2011年19-12] Proteomic studies have identified thousands of eukaryotic phosphorylation sites (phosphosites), but few are functionally characterized. Nishi et al., in this issue of Structure, characterize phosphosites at protein-prote... Creating Order out of Disorder: Structural Imprint of GAPDH on CP12 [作者：Gontero, B; Avilan, L,期刊：Structure, 页码：1728-1729 , 文章类型： Editorial Material，,卷期：2011年19-12] The work presented by Matsumura et al. in this issue of Structure describes the structure of the ternary GAPDH-NAD-CP12 and the binary NAD-GAPDH complex in the cyanobacterium Synechococcus elongatus. Terpenoid Synthases-From Chemical Ecology and Forest Fires to Biofuels and Bioproducts [作者：Bohlmann, J,期刊：Structure, 页码：1730-1731 , 文章类型： Editorial Material，,卷期：2011年19-12] Terpenoids are a diverse group of natural products with a myriad functions in ecological interactions of living organisms. Terpenoid synthases provide a unique reservoir of enzymes for the metabolic engineering of advanc... First Crystal Structures of Na(+),K(+)-ATPase: New Light on the Oldest Ion Pump [作者：Toyoshima, C; Kanai, R; Cornelius, F,期刊：Structure, 页码：1732-1738 , 文章类型： Article，,卷期：2011年19-12] Na(+),K(+)-adenosine triphosphatase (NKA) is the first P-type ion translocating adenosine triphosphatase (ATPase) ever identified, and the significance of this class of proteins was highlighted by the 1997 Nobel Prize in... Real Space Refinement of Crystal Structures with Canonical Distributions of Electrons [作者：Ginzinger, SW; Gruber, M; Brandstetter, H; Sippl, MJ,期刊：Structure, 页码：1739-1743 , 文章类型： Article，,卷期：2011年19-12] Recurring groups of atoms in molecules are surrounded by specific canonical distributions of electrons. Deviations from these distributions reveal unrealistic molecular geometries. Here, we show how canonical electron de... Automated Prediction of Protein Association Rate Constants [作者：Qin, S; Pang, XD; Zhou, HX,期刊：Structure, 页码：1744-1751 , 文章类型： Article，,卷期：2011年19-12] The association rate constants (k(a)) of proteins with other proteins or other macromolecular targets are a fundamental biophysical property. Observed rate constants span over ten orders of magnitude, from 1 to 10(10) M(... Structural Insights into the Autoactivation Mechanism of p21-Activated Protein Kinase [作者：Wang, J; Wu, JW; Wang, ZX,期刊：Structure, 页码：1752-1761 , 文章类型： Article，,卷期：2011年19-12] p21-activated kinases (PAKs) play an important role in diverse cellular processes. Full activation of PAKs requires autophosphorylation of a critical threonine/serine located in the activation loop of the kinase domain. ... Extracellular Complexes of the Hematopoietic Human and Mouse CSF-1 Receptor Are Driven by Common Assembly Principles [作者：Elegheert, J; Desfosses, A; Shkumatov, AV; Wu, XW; Bracke, N; Verstraete, K; Van Craenenbroeck, K; Brooks, BR; Svergun, DI; Vergauwen, B; Gutsche, I; Savvides, SN,期刊：Structure, 页码：1762-1772 , 文章类型： Article，,卷期：2011年19-12] The hematopoietic colony stimulating factor-1 receptor (CSF-1R or FMS) is essential for the cellular repertoire of the mammalian immune system. Here, we report a structural and mechanistic consensus for the assembly of h... Structure of Hydrogenase Maturation Protein HypF with Reaction Intermediates Shows Two Active Sites [作者：Petkun, S; Shi, R; Li, YG; Asinas, A; Munger, C; Zhang, LH; Waclawek, M; Soboh, B; Sawers, RG; Cygler, M,期刊：Structure, 页码：1773-1783 , 文章类型： Article，,卷期：2011年19-12] [NiFe]-hydrogenases are multimeric proteins. The large subunit contains the NiFe(CN)(2)CO bimetallic active center and the small subunit contains Fe-S clusters. Biosynthesis and assembly of the NiFe(CN)(2)CO active cente... Atomic-Level Protein Structure Refinement Using Fragment-Guided Molecular Dynamics Conformation Sampling [作者：Zhang, J; Liang, Y; Zhang, Y,期刊：Structure, 页码：1784-1795 , 文章类型： Article，,卷期：2011年19-12] One of critical difficulties of molecular dynamics (MD) simulations in protein structure refinement is that the physics-based energy landscape lacks a middle-range funnel to guide nonnative conformations toward near-nati... Galline Ex-FABP Is an Antibacterial Siderocalin and a Lysophosphatidic Acid Sensor Functioning through Dual Ligand Specificities [作者：Correnti, C; Clifton, MC; Abergel, RJ; Allred, B; Hoette, TM; Ruiz, M; Cancedda, R; Raymond, KN; Descalzi, F; Strong, RK,期刊：Structure, 页码：1796-1806 , 文章类型： Article，,卷期：2011年19-12] Galline Ex-FABP was identified as another candidate antibacterial, catecholate siderophore binding lipocalin (siderocalin) based on structural parallels with the family archetype, mammalian Siderocalin. Binding assays sh... Phosphorylation in Protein-Protein Binding: Effect on Stability and Function [作者：Nishi, H; Hashimoto, K; Panchenko, AR,期刊：Structure, 页码：1807-1815 , 文章类型： Article，,卷期：2011年19-12] Posttranslational modifications offer a dynamic way to regulate protein activity, subcellular localization, and stability. Here we estimate the effect of phosphorylation on protein binding and function for different type... Crystallographic Analysis of Polypyrimidine Tract-Binding Protein-Raver1 Interactions Involved in Regulation of Alternative Splicing [作者：Joshi, A; Coelho, MB; Kotik-Kogan, O; Simpson, PJ; Matthews, SJ; Smith, CWJ; Curry, S,期刊：Structure, 页码：1816-1825 , 文章类型： Article，,卷期：2011年19-12] The polypyrimidine tract-binding protein (PTB) is an important regulator of alternative splicing. PTB-regulated splicing of alpha-tropomyosin is enhanced by Raver1, a protein with four PTB-Raver1 interacting motifs (PRIs... Tandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASK [作者：Stafford, RL; Hinde, E; Knight, MJ; Pennella, MA; Ear, J; Digman, MA; Gratton, E; Bowie, JU,期刊：Structure, 页码：1826-1836 , 文章类型： Article，,卷期：2011年19-12] The synaptic scaffolding proteins CASK and Caskin1 are part of the fibrous mesh of proteins that organize the active zones of neural synapses. CASK binds to a region of caskin1 called the CASK interaction domain (CID). A...