- Symmetry-Restrained Flexible Fitting for Symmetric EM Maps
[作者：Chan, KY; Gumbart, J; McGreevy, R; Watermeyer, JM; Sewell, BT; Schulten, K,期刊：Structure, 页码：1211-1218 , 文章类型： Article，,卷期：2011年19-9]
- Many large biological macromolecules have inherent structural symmetry, being composed of a few distinct subunits, repeated in a symmetric array. These complexes are often not amenable to traditional high-resolution stru...
- Unusual, Dual Endo- and Exonuclease Activity in the Degradosome Explained by Crystal Structure Analysis of RNase J1
[作者：Newman, JA; Hewitt, L; Rodrigues, C; Solovyova, A; Harwood, CR; Lewis, RJ,期刊：Structure, 页码：1241-1251 , 文章类型： Article，,卷期：2011年19-9]
- RNase J is an essential enzyme in Bacillus subtilis with unusual dual endonuclease and 5'-to-3' exonuclease activities that play an important role in the maturation and degradation of mRNA. RNase J is also a component of...
- Molecular Basis for the Recognition and Cleavage of RNA by the Bifunctional 5 '-3 ' Exo/Endoribonuclease RNase J
[作者：Dorleans, A; de la Sierra-Gallay, IL; Piton, J; Zig, L; Gilet, L; Putzer, H; Condon, C,期刊：Structure, 页码：1252-1261 , 文章类型： Article，,卷期：2011年19-9]
- RNase J is a key member of the beta-CASP family of metallo-beta-lactamases involved in the maturation and turnover of RNAs in prokaryotes. The B. subtilis enzyme possesses both 5'-3' exoribonucleolytic and endonucleolyti...
- Structural Basis of Substrate Methylation and Inhibition of SMYD2
[作者：Ferguson, AD; Larsen, NA; Howard, T; Pollard, H; Green, I; Grande, C; Cheung, T; Garcia-Arenas, R; Cowen, S; Wu, JQ; Godin, R; Chen, HW; Keen, N,期刊：Structure, 页码：1262-1273 , 文章类型： Article，,卷期：2011年19-9]
- Protein lysine methyltransferases are important regulators of epigenetic signaling. These enzymes catalyze the transfer of donor methyl groups from S-adenosylmethionine to specific acceptor lysines on histones, leading t...
- Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry
[作者：Rose, RJ; Labrijn, AF; van den Bremer, ETJ; Loverix, S; Lasters, I; van Berkel, PHC; van de Winkel, JGJ; Schuurman, J; Parren, PWHI; Heck, AJR,期刊：Structure, 页码：1274-1282 , 文章类型： Article，,卷期：2011年19-9]
- Native mass spectrometry (MS) is a powerful technique for studying noncovalent protein-protein interactions. Here, native MS was employed to examine the noncovalent interactions involved in homodimerization of antibody h...
- Structure of the Adenosine A(2A) Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine
[作者：Dore, AS; Robertson, N; Errey, JC; Ng, I; Hollenstein, K; Tehan, B; Hurrell, E; Bennett, K; Congreve, M; Magnani, F; Tate, CG; Weir, M; Marshall, FH,期刊：Structure, 页码：1283-1293 , 文章类型： Article，,卷期：2011年19-9]
- Methylxanthines, including caffeine and theophylline, are among the most widely consumed stimulant drugs in the world. These effects are mediated primarily via blockade of adenosine receptors. Xanthine analogs with impro...
- Structural Basis for Complex Formation between Human IRSp53 and the Translocated Intimin Receptor Tir of Enterohemorrhagic E. coil
[作者：de Groot, JC; Schluter, K; Carius, Y; Quedenau, C; Vingadassalom, D; Faix, J; Weiss, SM; Reichelt, J; Standfuss-Gabisch, C; Lesser, CF; Leong, JM; Heinz, DW; Bussow, K; Stradal, TEB,期刊：Structure, 页码：1294-1306 , 文章类型： Article，,卷期：2011年19-9]
- Actin assembly beneath enterohemorrhagic E. coil (EHEC) attached to its host cell is triggered by the intracellular interaction of its translocated effector proteins Tir and EspF(U) with human IRSp53 family proteins and ...
- Atomic Resolution Insights into Curli Fiber Biogenesis
[作者：Taylor, JD; Zhou, YZ; Salgado, PS; Patwardhan, A; McGuffie, M; Pape, T; Grabe, G; Ashman, E; Constable, SC; Simpson, PJ; Lee, WC; Cota, E; Chapman, MR; Matthews, SJ,期刊：Structure, 页码：1307-1316 , 文章类型： Article，,卷期：2011年19-9]
- Bacteria produce functional amyloid fibers called curli in a controlled, noncytotoxic manner. These extracellular fimbriae enable biofilm formation and promote pathogenicity. Understanding curli biogenesis is important f...
- Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication
[作者：Osborne, BW; Wu, J; McFarland, CJ; Nickl, CK; Sankaran, B; Casteel, DE; Woods, VL; Kornev, AP; Taylor, SS; Dostmann, WR,期刊：Structure, 页码：1317-1327 , 文章类型： Article，,卷期：2011年19-9]
- The cGMP-dependent protein kinase (PKG) serves as an integral component of second messenger signaling in a number of biological contexts including cell differentiation, memory, and vasodilation. PKG is homodimeric and la...
- Characterization of the Structure and Function of Escherichia coil DegQ as a Representative of the DegQ-like Proteases of Bacterial HtrA Family Proteins
[作者：Bai, XC; Pan, XJ; Wang, XJ; Ye, YY; Chang, LF; Leng, D; Lei, JL; Sui, SF,期刊：Structure, 页码：1328-1337 , 文章类型： Article，,卷期：2011年19-9]
- HtrA family proteins play a central role in protein quality control in the bacterial periplasmic space. DegQ-like proteases, a group of bacterial HtrA proteins, are characterized by a short LA loop as compared with DegP-...
- Biophysical and Computational Studies of Membrane Penetration by the GRP1 Pleckstrin Homology Domain
[作者：Lumb, CN; He, J; Xue, Y; Stansfeld, PJ; Stahelin, RV; Kutateladze, TG; Sansom, MSP,期刊：Structure, 页码：1338-1346 , 文章类型： Article，,卷期：2011年19-9]
- The pleckstrin homology (PH) domain of the general receptor for phosphoinositides 1 (GRP1) exhibits specific, high-affinity, reversible binding to phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P(3)) at the plasma ...
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