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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   Membrane Protein Structure Determination using Paramagnetic Tags [作者：Ganguly, S; Weiner, BE; Meiler, J,期刊：Structure, 页码：441-443 , 文章类型： Editorial Material，,卷期：2011年19-4] The combination of paramagnetic tagging strategies with NMR or EPR spectroscopic techniques can revolutionize de novo structure determination of helical membrane proteins. Leveraging the full potential of this approach r... Deuterium Reveals the Dynamics of Notch Activation [作者：Raphael, K,期刊：Structure, 页码：443-444 , 文章类型： Editorial Material，,卷期：2011年19-4] Notch activation requires unfolding of a juxtamembrane negative regulatory domain (NRR). Tiyanont et al. (2011) analyzed the dynamics of NRR unfolding in the presence of EGTA. As predicted from the crystal structure and ... Closing In on the Hsp90 Chaperone-Client Relationship [作者：Richter, K; Buchner, J,期刊：Structure, 页码：445-446 , 文章类型： Editorial Material，,卷期：2011年19-4] The molecular chaperone Hsp90 regulates the activity and stability of a set of client proteins. Despite progress in understanding its mechanism, the interaction of Hsp90 with clients has remained enigmatic. Now, in a rec... The Structural Biology of Toll-like Receptors [作者：Botos, I; Segal, DM; Davies, DR,期刊：Structure, 页码：447-459 , 文章类型： Review，,卷期：2011年19-4] The membrane-bound Toll-like receptors (TLRs) trigger innate immune responses after recognition of a wide variety of pathogen-derived compounds. Despite the wide range of ligands recognized by TLRs, the receptors share a... Remote Thioredoxin Recognition Using Evolutionary Conservation and Structural Dynamics [作者：Tang, GW; Altman, RB,期刊：Structure, 页码：461-470 , 文章类型： Article，,卷期：2011年19-4] The thioredoxin family of oxidoreductases plays an important role in redox signaling and control of protein function. Not only are thioredoxins linked to a variety of disorders, but their stable structure has also seen a... Crystal Structure of Type III Glutamine Synthetase: Surprising Reversal of the Inter-Ring Interface [作者：van Rooyen, JM; Abratt, VR; Belrhali, H; Sewell, T,期刊：Structure, 页码：471-483 , 文章类型： Article，,卷期：2011年19-4] Glutamine synthetases are ubiquitous, homo-oligomeric enzymes essential for nitrogen metabolism. Unlike types I and II, which are well described both structurally and functionally, the larger, type Ills are poorly charac... Optimal Mutation Sites for PRE Data Collection and Membrane Protein Structure Prediction [作者：Chen, HL; Ji, F; Olman, V; Mobley, CK; Liu, YZ; Zhou, YP; Bushweller, JH; Prestegard, JH; Xu, Y,期刊：Structure, 页码：484-495 , 文章类型： Article，,卷期：2011年19-4] Nuclear magnetic resonance paramagnetic relaxation enhancement (PRE) measures long-range distances to isotopically labeled residues, providing useful constraints for protein structure prediction. The method usually requi... Peering Down the Barrel of a Bacteriophage Portal: The Genome Packaging and Release Valve in P22 [作者：Tang, JH; Lander, GC; Olia, A; Li, R; Casjens, S; Prevelige, P; Cingolani, G; Baker, TS; Johnson, JE,期刊：Structure, 页码：496-502 , 文章类型： Article，,卷期：2011年19-4] The encapsidated genome in all double-strand DNA bacteriophages is packaged to liquid crystalline density through a unique vertex in the procapsid assembly intermediate, which has a portal protein dodecamer in place of f... The Hypoxic Regulator of Sterol Synthesis Nro1 Is a Nuclear Import Adaptor [作者：Yeh, TL; Lee, CYS; Amzel, LM; Espenshade, PJ; Bianchet, MA,期刊：Structure, 页码：503-514 , 文章类型： Article，,卷期：2011年19-4] Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Nro1 regulates the stab... Structural Insights into the Architecture and Allostery of Full-Length AMP-Activated Protein Kinase [作者：Zhu, L; Chen, L; Zhou, XM; Zhang, YY; Zhang, YJ; Zhao, J; Ji, SR; Wu, JW; Wu, Y,期刊：Structure, 页码：515-522 , 文章类型： Article，,卷期：2011年19-4] AMP-activated protein kinase (AMPK) is a heterotrimeric complex composed of alpha catalytic subunit, beta scaffolding subunit, and gamma regulatory subunit with critical roles in maintaining cellular energy homeostasis. ... Reintroducing Electrostatics into Macromolecular Crystallographic Refinement: Application to Neutron Crystallography and DNA Hydration [作者：Fenn, TD; Schnieders, MJ; Mustyakimov, M; Wu, CJ; Langan, P; Pande, VS; Brunger, AT,期刊：Structure, 页码：523-533 , 文章类型： Article，,卷期：2011年19-4] Most current crystallographic structure refinements augment the diffraction data with a priori information consisting of bond, angle, dihedral, planarity restraints, and atomic repulsion based on the Pauli exclusion prin... Locked Tether Formation by Cooperative Folding of Rna14p Monkeytail and Rna15p Hinge Domains in the Yeast CF IA Complex [作者：Moreno-Morcillo, M; Minvielle-Sebastia, L; Fribourg, S; Mackereth, CD,期刊：Structure, 页码：534-545 , 文章类型： Article，,卷期：2011年19-4] The removal of the 3' region of pre-mRNA followed by polyadenylation is a key step in mRNA maturation. In the yeast Saccharomyces cerevisiae, one component of the processing machinery is the cleavage/polyadenylation fact... Evidence for Increased Exposure of the Notch1 Metalloprotease Cleavage Site upon Conversion to an Activated Conformation [作者：Tiyanont, K; Wales, TE; Aste-Amezaga, M; Aster, JC; Engen, JR; Blacklow, SC,期刊：Structure, 页码：546-554 , 文章类型： Article，,卷期：2011年19-4] Notch proteins are transmembrane receptors that normally adopt a resting state poised to undergo activating proteolysis upon ligand engagement. Receptor quiescence is maintained by three LIN12/Notch repeats (LNRs), which... A Multidomain Flexible Docking Approach to Deal with Large Conformational Changes in the Modeling of Biomolecular Complexes [作者：Karaca, E; Bonvin, AMJJ,期刊：Structure, 页码：555-565 , 文章类型： Article，,卷期：2011年19-4] Binding-induced backbone and large-scale conformational changes represent one of the major challenges in the modeling of biomolecular complexes by docking. To address this challenge, we have developed a flexible multidom... Beyond the Random Coil: Stochastic Conformational Switching in Intrinsically Disordered Proteins [作者：Choi, UB; McCann, JJ; Weninger, KR; Bowen, ME,期刊：Structure, 页码：566-576 , 文章类型： Article，,卷期：2011年19-4] Intrinsically disordered proteins (IDPs) participate in critical cellular functions that exploit the flexibility and rapid conformational fluctuations of their native state. Limited information about the native state of ... Structural Insights into Rcs Phosphotransfer: The Newly Identified RcsD-ABL Domain Enhances Interaction with the Response Regulator RcsB [作者：Schmoe, K; Rogov, VV; Rogova, NY; Lohr, F; Guntert, P; Bernhard, F; Dotschl, V,期刊：Structure, 页码：577-587 , 文章类型： Article，,卷期：2011年19-4] The Rcs-signaling system is one of the most remarkable phosphorelay pathways in Enterobacteriaceae, comprising several membrane-bound and soluble proteins. Within the complex phosphotransfer pathway, the histidine phosph...