- Tradition, tradition
[作者:Rockman, HA,期刊:Journal of clinical investigation, 页码:785-786 , 文章类型: Editorial Material,,卷期:2012年122-3]
- Starting with this issue, the Editorial duties for the JCI move to Duke University and the University of North Carolina at Chapel Hill. As we begin our five-year tenure at the helm of this prestigious journal, the tradit...
- MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans
[作者:Hughes, CR; Guasti, L; Meimaridou, E; Chuang, CH; Schimenti, JC; King, PJ; Costigan, C; Clark, AJL; Metherell, LA,期刊:Journal of clinical investigation, 页码:814-820 , 文章类型: Article,,卷期:2012年122-3]
- An interesting variant of familial glucocorticoid deficiency (FGD), an autosomal recessive form of adrenal failure, exists in a genetically isolated Irish population. In addition to hypocortisolemia, affected children sh...
- Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency
[作者:Gineau, L; Cognet, C; Kara, N; Lach, FP; Dunne, J; Veturi, U; Picard, C; Trouillet, C; Eidenschenk, C; Aoufouchi, S; Alcais, A; Smith, O; Geissmann, F; Feighery, C; Abel, L; Smogorzewska, A; Stillman, B; Vivier, E; Casanova, JL; Jouanguy, E,期刊:Journal of clinical investigation, 页码:821-832 , 文章类型: Article,,卷期:2012年122-3]
- Natural killer (NK) cells are circulating cytotoxic lymphocytes that exert potent and nonredundant antiviral activity and antitumoral activity in the mouse; however, their function in host defense in humans remains uncle...
- ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
[作者:Casimiro, MC; Crosariol, M; Loro, E; Ertel, A; Yu, ZR; Dampier, W; Saria, EA; Papanikolaou, A; Stanek, TJ; Li, ZP; Wang, CG; Fortina, P; Addya, S; Tozeren, A; Knudsen, ES; Arnold, A; Pestell, RG,期刊:Journal of clinical investigation, 页码:833-843 , 文章类型: Article,,卷期:2012年122-3]
- Chromosomal instability (CIN) in tumors is characterized by chromosomal abnormalities and an altered gene expression signature; however, the mechanism of CIN is poorly understood. CCND1 (which encodes cyclin D1) is overe...
- p27(Kip1) controls cytokinesis via the regulation of citron kinase activation
[作者:Serres, MP; Kossatz, U; Chi, Y; Roberts, JM; Malek, NP; Besson, A,期刊:Journal of clinical investigation, 页码:844-858 , 文章类型: Article,,卷期:2012年122-3]
- p27(Kip1) (p27) acts as a tumor suppressor by inhibiting cyclin-cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27(CK-)) have...
- DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
[作者:Taira, N; Mimoto, R; Kurata, M; Yamaguchi, T; Kitagawa, M; Miki, Y; Yoshida, K,期刊:Journal of clinical investigation, 页码:859-872 , 文章类型: Article,,卷期:2012年122-3]
- Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c-Jun and c-Myc are indispensable regulators at this transition, and their aberrant expressio...
- Modulation of noncanonical TGF-beta signaling prevents cleft palate in Tgfbr2 mutant mice
[作者:Iwata, J; Hacia, JG; Suzuki, A; Sanchez-Lara, PA; Urata, M; Chai, Y,期刊:Journal of clinical investigation, 页码:873-885 , 文章类型: Article,,卷期:2012年122-3]
- Patients with mutations in either TGF-beta receptor type I (TGFBR1) or TGF-beta receptor type II (TGFBR2), such as those with Loeys-Dietz syndrome, have craniofacial defects and signs of elevated TGF-beta signaling. Simi...
- PPAR gamma agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma
[作者:Charytonowicz, E; Terry, M; Coakley, K; Telis, L; Remotti, F; Cordon-Cardo, C; Taub, RN; Matushansky, I,期刊:Journal of clinical investigation, 页码:886-898 , 文章类型: Article,,卷期:2012年122-3]
- Myxoid round cell liposarcoma (MRCLS) is a common liposarcoma subtype characterized by a translocation that results in the fusion protein TLS:CHOP as well as by mixed adipocytic histopathology. Both the etiology of MRCLS...
- Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
[作者:Salmon, H; Franciszkiewicz, K; Damotte, D; Dieu-Nosjean, MC; Validire, P; Trautmann, A; Mami-Chouaib, F; Donnadieu, E,期刊:Journal of clinical investigation, 页码:899-910 , 文章类型: Article,,卷期:2012年122-3]
- Appropriate localization and migration of T cells is a prerequisite for antitumor immune surveillance. Studies using fixed tumor samples from human patients have shown that T cells accumulate more efficiently in the stro...
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