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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   Human Tripeptidyl Peptidase II: A Gentle Giant [作者：Glaeser, RM,期刊：Structure, 页码：565-566 , 文章类型： Editorial Material，,卷期：2012年20-4] Molecular structures can serve to either validate or rule out existing hypotheses, and they can also spawn new, deeper proposals about biochemical mechanism. In this issue of Structure, Schonegge et al. use single-partic... XPF-ERCC1: On the Bubble [作者：Shell, SM; Chazin, WJ,期刊：Structure, 页码：566-568 , 文章类型： Editorial Material，,卷期：2012年20-4] In this issue of Structure, Das et al. report the structure of the helix-hairpin-helix dimerization domain of XPF bound to ssDNA. These results provide insight into the architecture of nucleotide excision repair machiner... Discoidin Discoveries [作者：Ferguson, KM,期刊：Structure, 页码：568-570 , 文章类型： Editorial Material，,卷期：2012年20-4] In this issue of Structure, Carafoli et al. investigate the mode of antibody-mediated inhibition of the discoidin domain receptor 1 (DDR1). These studies also provide new insight into activation of the DDRs, which are un... Phosphorylation Meets Proteolysis [作者：Renatus, M; Farady, CJ,期刊：Structure, 页码：570-571 , 文章类型： Editorial Material，,卷期：2012年20-4] Phosphorylation is a reversible post-translational modification that regulates many proteins and enzymes, including proteases, as shown by two recent publications. Huang and colleagues and Velazquez-Delgado and Hardy (th... Methionine Scanning as an NMR Tool for Detecting and Analyzing Biomolecular Interaction Surfaces [作者：Stoffregen, MC; Schwer, MM; Renschler, FA; Wiesner, S,期刊：Structure, 页码：573-581 , 文章类型： Article，,卷期：2012年20-4] Methyl NMR spectroscopy is a powerful tool for studying protein structure, dynamics, and interactions. Yet difficulties with resonance assignment and the low abundance of methyl groups can preclude detailed NMR studies, ... Fabs Enable Single Particle cryoEM Studies of Small Proteins [作者：Wu, SP; Avila-Sakar, A; Kim, J; Booth, DS; Greenberg, CH; Rossi, A; Liao, MF; Li, XM; Alian, A; Griner, SL; Juge, N; Yu, YD; Mergel, CM; Chaparro-Riggers, J; Strop, P; Tampe, R; Edwards, RH; Stroud, RM; Craik, CS; Cheng, YF,期刊：Structure, 页码：582-592 , 文章类型： Article，,卷期：2012年20-4] In spite of its recent achievements, the technique of single particle electron cryomicroscopy (cryoEM) has not been widely used to study proteins smaller than 100 kDa, although it is a highly desirable application of thi... The Structure of Human Tripeptidyl Peptidase II as Determined by a Hybrid Approach [作者：Schonegge, AM; Villa, E; Forster, F; Heger, R; Peters, J; Baumeister, W; Rockel, B,期刊：Structure, 页码：593-603 , 文章类型： Article，,卷期：2012年20-4] Tripeptidyl-peptidase II (TPPII) is a high molecular mass (similar to 5 MDa) serine protease, which is thought to act downstream of the 26S proteasome, cleaving peptides released by the latter. Here, the structure of hum... Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53 [作者：Zanier, K; Sidi, AOMO; Boulade-Ladame, C; Rybin, V; Chappelle, A; Atkinson, A; Kieffer, B; Trave, G,期刊：Structure, 页码：604-617 , 文章类型： Article，,卷期：2012年20-4] The viral oncoprotein E6 is an essential factor for cervical cancers induced by "high-risk" mucosal HPV. Among other oncogenic activities, E6 recruits the ubiquitin ligase E6AP to promote the ubiquitination and subsequen... How Conformational Dynamics of DNA Polymerase Select Correct Substrates: Experiments and Simulations [作者：Kirmizialtin, S; Nguyen, V; Johnson, KA; Elber, R,期刊：Structure, 页码：618-627 , 文章类型： Article，,卷期：2012年20-4] Nearly every enzyme undergoes a significant change in structure after binding it's substrate. Experimental and theoretical analyses of the role of changes in HIV reverse transcriptase structure in selecting a correct sub... Dissecting the Kinematics of the Kinesin Step [作者：Zhang, ZC; Thirumalai, D,期刊：Structure, 页码：628-640 , 文章类型： Article，,卷期：2012年20-4] Kinesin walks processively on microtubules in an asymmetric hand-over-hand manner with each step spanning 16 nm. We used molecular simulations to determine the fraction of a single step due to conformational changes in t... Comparison between Actin Filament Models: Coarse-Graining Reveals Essential Differences [作者：Saunders, MG; Voth, GA,期刊：Structure, 页码：641-653 , 文章类型： Article，,卷期：2012年20-4] The interconversion of actin between monomeric and polymeric forms is a fundamental process in cell biology that is incompletely understood, in part because there is no high-resolution structure for filamentous actin. Se... Asymmetric Mode of Ca2+-S100A4 Interaction with Nonmuscle Myosin IIA Generates Nanomolar Affinity Required for Filament Remodeling [作者：Elliott, PR; Irvine, AF; Jung, HS; Tozawa, K; Pastok, MW; Picone, R; Badyal, SK; Basran, J; Rudland, PS; Barraclough, R; Lian, LY; Bagshaw, CR; Kriajevska, M; Barsukov, IL,期刊：Structure, 页码：654-666 , 文章类型： Article，,卷期：2012年20-4] Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca2+-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers. Our NMR structure shows that a... The Structure of the XPF-ssDNA Complex Underscores the Distinct Roles of the XPF and ERCC1 Helix-Hairpin-Helix Domains in ss/ds DNA Recognition [作者：Das, D; Folkers, GE; van Dijk, M; Jaspers, NGJ; Hoeijmakers, JHJ; Kaptein, R; Boelens, R,期刊：Structure, 页码：667-675 , 文章类型： Article，,卷期：2012年20-4] Human XPF/ERCC1 is a structure-specific DNA endonuclease that nicks the damaged DNA strand at the 5' end during nucleotide excision repair. We determined the structure of the complex of the C-terminal domain of XPF with ... Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R [作者：Ma, XL; Lin, WY; Chen, YM; Stawicki, S; Mukhyala, K; Wu, Y; Martin, F; Bazan, JF; Starovasnik, MA,期刊：Structure, 页码：676-687 , 文章类型： Article，,卷期：2012年20-4] Lacking any discernible sequence similarity, interleukin-34 (IL-34) and colony stimulating factor 1 (CSF-1) signal through a common receptor CSF-1 R on cells of mononuclear phagocyte lineage. Here, the crystal structure ... Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling [作者：Carafoli, F; Mayer, MC; Shiraishi, K; Pecheva, MA; Chan, LY; Nan, R; Leitinger, B; Hohenester, E,期刊：Structure, 页码：688-697 , 文章类型： Article，,卷期：2012年20-4] The discoidin domain receptors, DDR1 and DDR2, are constitutively dimeric receptor tyrosine kinases that are activated by triple-helical collagen. Aberrant DDR signaling contributes to several human pathologies, includin... Crystal Structures of Aureochrome1 LOV Suggest New Design Strategies for Optogenetics [作者：Mitre, D; Yang, XJ; Moffat, K,期刊：Structure, 页码：698-706 , 文章类型： Article，,卷期：2012年20-4] Aureochrome1, a signaling photoreceptor from a eukaryotic photosynthetic stramenopile, confers blue-light-regulated DNA binding on the organism. Its topology, in which a C-terminal LOV sensor domain is linked to an N-ter...