- Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts
[作者:Baschnagel, A; Russo, A; Burgan, WE; Carter, D; Beam, K; Palmieri, D; Steeg, PS; Tofilon, P; Camphausen, K,期刊:Molecular Cancer Therapeutics, 页码:1589-1595 , 文章类型: Article,,卷期:2009年8-6]
- Vorinostat (suberoylanilide hydroxamic acid), a histone deacetylase inhibitor, is currently undergoing clinical evaluation as therapy for cancer. We investigated the effects of vorinostat on tumor cell radiosensitivity i...
- Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice
[作者:Shankar, S; Davis, R; Singh, KP; Kurzrock, R; Ross, DD; Srivastava, RK,期刊:Molecular Cancer Therapeutics, 页码:1596-1605 , 文章类型: Article,,卷期:2009年8-6]
- The purpose of this study was to examine whether histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA; Zolinza/vorinostat) could sensitize tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-re...
- Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-kappa B activity via direct interaction with p50
[作者:Ban, JO; Oh, JH; Hwang, BY; Moon, DC; Jeong, HS; Lee, S; Kim, S; Lee, H; Kim, KB; Han, SB; Hong, JT,期刊:Molecular Cancer Therapeutics, 页码:1613-1624 , 文章类型: Article,,卷期:2009年8-6]
- Kaurane diterpene compounds have been known to be cytotoxic against several cancer cells through inhibition of nuclear factor-kappa B (NF-kappa B) activity. Here, we showed that inflexinol, a novel kaurane diterpene comp...
- SHP and Sin3A expression are essential for adamantyl-substituted retinoid-related molecule-mediated nuclear factor-kappa B activation, c-Fos/c-Jun expression, and cellular apoptosis
[作者:Farhana, L; Dawson, MI; Xu, LP; Fontana, JA,期刊:Molecular Cancer Therapeutics, 页码:1625-1635 , 文章类型: Article,,卷期:2009年8-6]
- We previously found that the adamantyl-substituted retinoid-related molecules bind to the small heterodimer partner (SHP) as well as the Sin3A complex. In this report, we delineated the role of SHP and the Sin3A complex ...
- IKK beta-mediated nuclear factor-kappa B activation attenuates smac mimetic-induced apoptosis in cancer cells
[作者:Lai, L; Chen, WS; Chen, WJ; Wang, X; Tang, H; Lin, Y,期刊:Molecular Cancer Therapeutics, 页码:1636-1645 , 文章类型: Article,,卷期:2009年8-6]
- Smac mimetics (SM) have been recently reported to kill cancer cells through the extrinsic apoptosis pathway mediated by autocrine tumor necrosis factor (TNF). SM also activates nuclear factor-kappa B (NF-kappa B). Howeve...
- Luteinizing hormone-releasing hormone receptor-targeted deslorelin-docetaxel conjugate enhances efficacy of docetaxel in prostate cancer therapy
[作者:Sundaram, S; Durairaj, C; Kadam, R; Kompella, UB,期刊:Molecular Cancer Therapeutics, 页码:1655-1665 , 文章类型: Article,,卷期:2009年8-6]
- Docetaxel, a chemotherapeutic agent currently used for improving survival of prostate cancer patients, suffers from low therapeutic index. The objective of this study was to prepare a new docetaxel derivative conjugated ...
- The anti proliferative cytostatic effects of a self-activating viridin prodrug
[作者:Smith, A; Blois, J; Yuan, H; Aikawa, E; Ellson, C; Figueiredo, JL; Weissleder, R; Kohler, R; Yaffe, MB; Cantley, LC; Josephson, L,期刊:Molecular Cancer Therapeutics, 页码:1666-1675 , 文章类型: Article,,卷期:2009年8-6]
- Although viridins like wortmannin (Wm) have long been examined as anticancer agents, their ability to self-activate has only recently been recognized. Here, we describe the cytostatic effects of a self-activating viridin...
- Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin
[作者:Zhou, Q; Yan, B; Hu, XW; Li, XB; Zhang, J; Fang, J,期刊:Molecular Cancer Therapeutics, 页码:1684-1691 , 文章类型: Article,,卷期:2009年8-6]
- Luteolin, a common dietary flavonoid, has been found to have antitumor properties and therefore poses special interest for the development of preventive and/or therapeutic agent for cancers. E-cadherin, a marker of epith...
- Lysophosphatidic acid stimulates cell migration, invasion, and colony formation as well as tumorigenesis/metastasis of mouse ovarian cancer in immunocompetent mice
[作者:Li, H; Wang, DM; Zhang, H; Kirmani, K; Zhao, ZW; Steinmetz, R; Xu, Y,期刊:Molecular Cancer Therapeutics, 页码:1692-1701 , 文章类型: Article,,卷期:2009年8-6]
- We have already established human xenographic models for the effect of lysophosphatidic acid (LPA) on tumor metastasis in vivo. The purpose of this work is to establish a preclinical LPA effect model in immunocompetent m...
- Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
[作者:Gu, YC; Patterson, AV; Atwell, GJ; Chernikova, SB; Brown, JM; Thompson, LH; Wilson, WR,期刊:Molecular Cancer Therapeutics, 页码:1714-1723 , 文章类型: Article,,卷期:2009年8-6]
- PR-104 is a dinitrobenzamide mustard currently in clinical trial as a hypoxia-activated prodrug. Its major metabolite, PR-104A, is metabolized to the corresponding hydroxylamine (PR-104H) and amine (PR-104M), resulting i...
- Phase I safety, pharmacokinetic, and pharmacogenomic trail of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors
[作者:Baird, RD; Kitzen, J; Clarke, PA; Planting, A; Reade, S; Reid, A; Welsh, L; Lazaro, LL; Heras, BDL; Judson, IR; Kaye, SB; Eskens, F; Workman, P; deBono, JS; Verweij, J,期刊:Molecular Cancer Therapeutics, 页码:1430-1437 , 文章类型: Article,,卷期:2009年8-6]
- A dose-escalation, phase I study evaluated the safety, pharmacokinetics, pharmacogenomics, and efficacy of ES-285, a novel agent isolated from a marine mollusc, in adult cancer patients. Patients received a 24-hour i.v. ...
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