- Regulation of D-cyclin translation inhibition in myeloma cells treated with mammalian target of rapamycin inhibitors: rationale for combined treatment with extracellular signal-regulated kinase inhibitors and rapamycin
[作者:Frost, P; Shi, YJ; Hoang, B; Gera, J; Lichtenstein, A,期刊:Molecular Cancer Therapeutics, 页码:83-93 , 文章类型: Article,,卷期:2009年8-1]
- We have shown that heightened AKT activity sensitized multiple myeloma cells to the antitumor effects of the mammalian target of rapamycin inhibitor CCI-779. To test the mechanism of the AKT regulatory role, we stably tr...
- Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
[作者:Choudhury, A; Zhao, HL; Jalali, F; Rashid, SA; Ran, J; Supiot, S; Kiltie, AE; Bristow, RG,期刊:Molecular Cancer Therapeutics, 页码:203-213 , 文章类型: Article,,卷期:2009年8-1]
- RAD51 is a key protein in the homologous recombination (HR) pathway of DNA double-strand break repair, and HR represents a novel target for cancer therapy. Because imatinib (Gleevec) has been reported to reduce RAD51 pro...
- Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity
[作者:Ihle, NT; Lemos, R; Schwartz, D; Oh, J; Halter, RJ; Wipf, P; Kirkpatrick, L; Powis, G,期刊:Molecular Cancer Therapeutics, 页码:94-100 , 文章类型: Article,,卷期:2009年8-1]
- The phosphatidylinositol 3-kinase (PI3K)/Akt signaling cascade is an important component of the insulin signaling in normal tissues leading to glucose uptake and homeostasis and for cell survival signaling in cancer cell...
- Synergy between phosphatidylinositol 3-kinase/Akt pathway and Bcl-xL in the control of apoptosis in adenocarcinoma cells of the lung
[作者:Qian, J; Zou, Y; Rahman, JSM; Lu, B; Massion, PP,期刊:Molecular Cancer Therapeutics, 页码:101-109 , 文章类型: Article,,卷期:2009年8-1]
- Adenocarcinomas of the lung commonly show an increase in the activity of phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, yet many are resistant to apoptosis induced by the inhibition of PI3K. We hypothesized ...
- Rosiglitazone inhibits alpha 4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals
[作者:Sun, XJ; Ritzenthaler, JD; Zheng, Y; Roman, J; Han, SW,期刊:Molecular Cancer Therapeutics, 页码:110-118 , 文章类型: Article,,卷期:2009年8-1]
- We and others have shown previously that nicotine, a major component of tobacco, stimulates non-small cell lung carcinoma (NSCLC) proliferation through nicotinic acetylcholine receptor (nAChR)-mediated signals. Activatio...
- Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation
[作者:Rius, M; Stresemann, C; Keller, D; Brom, M; Schirrmacher, E; Keppler, D; Lyko, F,期刊:Molecular Cancer Therapeutics, 页码:225-231 , 文章类型: Article,,卷期:2009年8-1]
- The DNA methyltransferase inhibitors 5-azacytidine (5-azaCyd) and 5-aza-2'-deoxycytidine have found increasing use for the treatment of myeloid leukemias and solid tumors. Both nucleoside analogues must be transported in...
- In vivo target-specific activatable near-infrared optical labeling of humanized monoclonal antibodies
[作者:Ogawa, M; Regino, CAS; Choyke, PL; Kobayashi, H,期刊:Molecular Cancer Therapeutics, 页码:232-239 , 文章类型: Article,,卷期:2009年8-1]
- Imaging with labeled monoclonal antibodies may be useful in detecting, staging, and monitoring tumors. Despite their high affinity and specificity, a critical limitation of antibody imaging is the high background signal ...
- Intensification therapy with anti-parathyroid hormone-related protein antibody plus zoledronic acid for bone metastases of small cell lung cancer cells in severe combined immunodeficient mice
[作者:Yamada, T; Muguruma, H; Yano, S; Ikuta, K; Ogino, H; Kakiuchi, S; Hanibuchi, M; Uehara, H; Nishioka, Y; Sone, S,期刊:Molecular Cancer Therapeutics, 页码:119-126 , 文章类型: Article,,卷期:2009年8-1]
- Bone metastases occur in more than one-third of patients with advanced lung cancer and are difficult to treat. We showed previously the therapeutic effect of a third-generation bisphosphonate, minodronate, and anti-parat...
- Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo
[作者:Burger, R; Le Gouill, S; Tai, YT; Shringarpure, R; Tassone, P; Neri, P; Podar, K; Catley, L; Hideshinl, T; Chauhan, D; Caulder, E; Neilan, CL; Vaddi, K; Li, J; Gramatzki, M; Fridman, JS; Anderson, KC,期刊:Molecular Cancer Therapeutics, 页码:26-35 , 文章类型: Article,,卷期:2009年8-1]
- Protein tyrosine kinases of the Janus kinase (JAK) family are associated with many cytokine receptors, which, on ligand binding, regulate important cellular functions such as proliferation, survival, and differentiation....
- UA62784, a novel inhibitor of centromere protein E kinesin-like protein
[作者:Henderson, MC; Shaw, YJY; Wang, H; Han, HY; Hurley, LH; Flynn, G; Dorr, RT; Hoff, DD,期刊:Molecular Cancer Therapeutics, 页码:36-44 , 文章类型: Article,,卷期:2009年8-1]
- Pancreatic carcinoma is the fourth leading cause of death from cancer. Novel targets and therapeutic options are needed to aid in the treatment of pancreatic cancer. The compound UA62784 is a novel fluorenone with inhibi...
- Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor
[作者:Huynh, H; Lee, JWJ; Chow, PKH; Ngo, VC; Bin Lew, G; Lam, IWL; Ong, HS; Chung, A; Soo, KC,期刊:Molecular Cancer Therapeutics, 页码:152-159 , 文章类型: Article,,卷期:2009年8-1]
- Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. Current therapeutic options include surgery and targeted molecular approaches such as imatinib and sunitinib. Our ...
- Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor
[作者:Sakurama, K; Noma, K; Takaoka, M; Tomono, Y; Watanabe, N; Hatakeyama, S; Ohmori, O; Hirota, S; Motoki, T; Shirakawa, Y; Yamatsuji, T; Haisa, M; Matsuoka, J; Tanaka, N; Naomoto, Y,期刊:Molecular Cancer Therapeutics, 页码:127-134 , 文章类型: Article,,卷期:2009年8-1]
- Focal adhesion kinase (FAK) is often up-regulated in a variety of malignancies, including gastrointestinal stromal tumor (GIST), and its overexpression seems to be associated with tumor progressiveness and poor prognosis...
- PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53
[作者:Mi, J; Mesta, E; Brautigan, DL; Larner, JM,期刊:Molecular Cancer Therapeutics, 页码:135-140 , 文章类型: Article,,卷期:2009年8-1]
- In response to ionizing radiation, p53 plays a critical role in regulating DNA repair and apoptosis. Among multiple phosphorylation sites, evidence suggests that Ser46 promotes apoptotic cell death through mitochondrial ...
- Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells
[作者:Parsels, LA; Morgan, MA; Tanska, DM; Parsels, JD; Palmer, BD; Booth, RJ; Denny, WA; Canman, CE; Kraker, AJ; Lawrence, TS; Maybaum, J,期刊:Molecular Cancer Therapeutics, 页码:45-54 , 文章类型: Article,,卷期:2009年8-1]
- The protein kinase checkpoint kinase1 (Chk1) has been implicated as a key regulator of cell cycle progression and DNA repair, and inhibitors of Chk1 (e.g., UCN-01 and EXEL-9844) potentiate the cytotoxic actions of chemot...
- Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68
[作者:Yu, YA; GalaniS, C; Woo, YH; Chen, NH; Zhang, Q; Fong, YM; Szalay, AA,期刊:Molecular Cancer Therapeutics, 页码:141-151 , 文章类型: Article,,卷期:2009年8-1]
- Oncolytic virotherapy of tumors has shown promising results in both preclinical and clinical studies. Here, we investigated the therapeutic efficacy of a replication-competent vaccinia virus, GLV-1h68, against human panc...
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