- Monoclonal antibody 16D10 to the COOH-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues
[作者：Benkoel, L; Bernard, JP; Payan-Defais, MJ; Crescence, L; Franceschi, C; Delmas, M; Ouaissi, M; Sastre, B; Sahel, J; Benoliel, AM; Bongrand, P; Silvy, F; Gauthier, L; Romagne, F; Lombardo, D; Mas, E,期刊：Molecular Cancer Therapeutics, 页码：282-291 , 文章类型： Article，,卷期：2009年8-2]
- We have shown that the 16D10 antigen located on the mucin-like COOH-terminal domain of the feto-acinar pancreatic protein (FAPP) is expressed at the surface of human pancreatic tumor cell lines such as SOJ-6 cell line. F...
- Mapatumumab and lexatumumab induce apoptosis in TRAIL-R1 and TRAIL-R2 antibody-resistant NSCLC cell lines when treated in combination with bortezomib
[作者：Luster, TA; Carrel, JA; McCormick, K; Sun, D; Humphreys, R,期刊：Molecular Cancer Therapeutics, 页码：292-302 , 文章类型： Article，,卷期：2009年8-2]
- Mapatumumab and lexatumumab are fully human monoclonal antibodies that bind and activate human tumor necrosis factor-related apoptosis-inducing ligand receptors 1 and 2, respectively. These antibodies induce apoptosis in...
- Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma
[作者：Milano, V; Piao, Y; LaFortune, T; de Groot, J,期刊：Molecular Cancer Therapeutics, 页码：394-406 , 文章类型： Article，,卷期：2009年8-2]
- Glioblastoma is defined by its aggressive invasion, microvascular proliferation, and central necrosis. BMS-354825 (dasatinib) is an ATP-competitive small-molecule inhibitor effective in treating drug-resistant tumors wit...
- Effective sensitization of temozolomide by ABT-888 is lost with development of temozolomide resistance in glioblastoma xenograft lines
[作者：Clarke, MJ; Mulligan, EA; Grogan, PT; Mladek, AC; Carlson, BL; Schroeder, MA; Curtin, NJ; Lou, ZK; Decker, PA; Wu, WT; Plummer, ER; Sarkaria, JN,期刊：Molecular Cancer Therapeutics, 页码：407-414 , 文章类型： Article，,卷期：2009年8-2]
- Resistance to temozolomide and radiotherapy is a major problem for patients with glioblastoma but may be overcome using the poly (AD P-ribose) polymerase inhibitor ABT-888. Using two primary glioblastoma xenografts, the ...
- Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells
[作者：Morales, C; Garcia, MJ; Ribas, M; Miro, R; Munoz, M; Caldas, C; Peinado, MA,期刊：Molecular Cancer Therapeutics, 页码：424-432 , 文章类型： Article，,卷期：2009年8-2]
- Gene amplification is one of the most frequent manifestations of genomic instability in human tumors and plays an important role in tumor progression and acquisition of drug resistance. To better understand the factors i...
- MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib
[作者：Houben, R; Voigt, H; Noelke, C; Hofmeister, V; Becker, JC; Schrama, D,期刊：Molecular Cancer Therapeutics, 页码：433-440 , 文章类型： Article，,卷期：2009年8-2]
- Sorafenib, originally developed as CRAF inhibitor but soon recognized as a multikinase inhibitor, is currently widely tested for the treatment of different cancers either alone or in combination therapy. However, the cli...
- Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1)
[作者：Guo, W; Wu, SH; Wang, L; Wang, RY; Wei, XL; Liu, JS; Fang, BL,期刊：Molecular Cancer Therapeutics, 页码：441-448 , 文章类型： Article，,卷期：2009年8-2]
- Protein kinase C iota (PKC iota) is activated by oncogenic Ras proteins and is required for K-Ras-induced transformation and colonic carcinogenesis in vivo. However, the role of PKC iota in signal transduction and oncoge...
- Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
[作者：Forni, C; Minuzzo, M; Virdis, E; Tamborini, E; Simone, M; Tavecchio, M; Erba, E; Grosso, F; Gronchi, A; Aman, P; Casali, P; D'Incalci, M; Pilotti, S; Mantovani, R,期刊：Molecular Cancer Therapeutics, 页码：449-457 , 文章类型： Article，,卷期：2009年8-2]
- Differentiation is a complex set of events that can be blocked by rearrangements of regulatory genes producing fusion proteins with altered properties. In the case of myxoid liposarcoma (MLS) tumors, the causative abnorm...
- WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G(1) arrest and growth inhibition of human invasive urinary bladder cancer cells
[作者：Tang, YX; Simoneau, AR; Liao, WX; Yi, G; Hope, C; Liu, F; Li, SQ; Xie, J; Holcombe, RF; Jurnak, FA; Mercola, D; Hoang, BH; Zi, XL,期刊：Molecular Cancer Therapeutics, 页码：458-468 , 文章类型： Article，,卷期：2009年8-2]
- Epigenetic silencing of secreted wingless-type (Wnt) antagonists through hypermethylation is associated with tobacco smoking and with invasive bladder cancer. The secreted Wnt inhibitory factor-1 (WIF1) has shown consist...
- Mechanisms involved in synergistic anticancer effects of anti-4-1BB and cyclophosphamide therapy
[作者：Kim, YH; Choi, BK; Oh, HS; Kang, WJ; Mittler, RS; Kwon, BS,期刊：Molecular Cancer Therapeutics, 页码：469-478 , 文章类型： Article，,卷期：2009年8-2]
- Chemotherapy can precondition for immunotherapy by creating an environment for homeostatic lymphoproliferation and eliminating some of the suppressive immune networks. We found that combination therapy with anti-4-1BB an...
- Discovery of Ixabepilone
[作者：Hunt, JT,期刊：Molecular Cancer Therapeutics, 页码：275-281 , 文章类型： Review，,卷期：2009年8-2]
- The discovery of the antineoplastic agent paclitaxel and its unique activity as a microtubule-stabilizing agent resulted in dramatic improvements in the treatment of breast, ovarian, and non-small cell lung cancers. Desp...
- A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development
[作者：Jimeno, A; Feldmann, G; Suarez-Gauthier, A; Rasheed, Z; Solomon, A; Zou, GM; Rubio-Viqueira, B; Garcia-Garcia, E; Lopez-Rios, F; Matsui, W; Maitra, A; Hidalgo, M,期刊：Molecular Cancer Therapeutics, 页码：310-314 , 文章类型： Article，,卷期：2009年8-2]
- There is an enormous gap between the antiproliferative and in vivo antitumor efficacy of gemcitabine in cell line-based models and its clinical efficacy. This may be due to insensitiveness of the precursor, cancer stem c...
- Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model
[作者：Dhar, A; Mehta, S; Dhar, G; Dhar, K; Banerjee, S; Van Veldhuizen, P; Campbell, DR; Banerjee, SK,期刊：Molecular Cancer Therapeutics, 页码：315-323 , 文章类型： Article，,卷期：2009年8-2]
- Crocetin, a carotenoid compound derived from saffron, has long been used as a traditional ancient medicine against different human diseases including cancer. The aim of the series of experiments was to systematically det...
- Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines
[作者：Squires, MS; Feltell, RE; Wallis, NG; Lewis, EJ; Smith, DM; Cross, DM; Lyons, JF; Thompson, NT,期刊：Molecular Cancer Therapeutics, 页码：324-332 , 文章类型： Article，,卷期：2009年8-2]
- Cyclin-dependent kinases (CDK), and their regulatory cyclin partners, play a central role in eukaryotic cell growth, division, and death. This key role in cell cycle progression, as well as their deregulation in several ...
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