- Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis
[作者：Greenberg, AS; Kraemer, FB; Soni, KG; Jedrychowski, MP; Yan, QW; Graham, CE; Bowman, TA; Mansur, A,期刊：EMBO journal, 页码：4337-4339 , 文章类型： Editorial Material，,卷期：2011年30-21]
- In response to adrenergic stimulation, adipocytes undergo protein kinase A (PKA)-stimulated lipolysis. A key PKA target in this context is perilipin 1, a major regulator of lipolysis on lipid droplets (LDs). A study publ...
- The mitochondrial contact site complex, a determinant of mitochondrial architecture
[作者：Harner, M; Korner, C; Walther, D; Mokranjac, D; Kaesmacher, J; Welsch, U; Griffith, J; Mann, M; Reggiori, F; Neupert, W,期刊：EMBO journal, 页码：4356-4370 , 文章类型： Article，,卷期：2011年30-21]
- Mitochondria are organelles with a complex architecture. They are bounded by an envelope consisting of the outer membrane and the inner boundary membrane (IBM). Narrow crista junctions (CJs) link the IBM to the cristae. ...
- Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis
[作者：Pidoux, G; Witczak, O; Jarnaess, E; Myrvold, L; Urlaub, H; Stokka, AJ; Kuntziger, T; Tasken, K,期刊：EMBO journal, 页码：4371-4386 , 文章类型： Article，,卷期：2011年30-21]
- Adrenergic stimulation of adipocytes yields a cAMP signal that activates protein kinase A (PKA). PKA phosphorylates perilipin, a protein localized on the surface of lipid droplets that serves as a gatekeeper to regulate ...
- Orientation-specific signalling by thrombopoietin receptor dimers
[作者：Staerk, J; Defour, JP; Pecquet, C; Leroy, E; Antoine-Poirel, H; Brett, I; Itaya, M; Smith, SO; Vainchenker, W; Constantinescu, SN,期刊：EMBO journal, 页码：4398-4413 , 文章类型： Article，,卷期：2011年30-21]
- Ligand binding to the thrombopoietin receptor is thought to stabilize an active receptor dimer that regulates megakaryocyte differentiation and platelet formation, as well as haematopoietic stem cell renewal. By fusing a...
- miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA
[作者：Hansen, TB; Wiklund, ED; Bramsen, JB; Villadsen, SB; Statham, AL; Clark, SJ; Kjems, J,期刊：EMBO journal, 页码：4414-4422 , 文章类型： Article，,卷期：2011年30-21]
- MicroRNAs (miRNAs) are similar to 22 nt non-coding RNAs that typically bind to the 3' UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can ...
- The mechanism of translation initiation on Aichivirus RNA mediated by a novel type of picornavirus IRES
[作者：Yu, YP; Sweeney, TR; Kafasla, P; Jackson, RJ; Pestova, TV; Hellen, CUT,期刊：EMBO journal, 页码：4423-4436 , 文章类型： Article，,卷期：2011年30-21]
- Picornavirus mRNAs contain IRESs that sustain their translation during infection, when host protein synthesis is shut off. The major classes of picornavirus IRESs (Types 1 and 2) have distinct structures and sequences, b...
- Crystal structures of an archaeal class II DNA photolyase and its complex with UV-damaged duplex DNA
[作者：Kiontke, S; Geisselbrecht, Y; Pokorny, R; Carell, T; Batschauer, A; Essen, LO,期刊：EMBO journal, 页码：4437-4449 , 文章类型： Article，,卷期：2011年30-21]
- Class II photolyases ubiquitously occur in plants, animals, prokaryotes and some viruses. Like the distantly related microbial class I photolyases, these enzymes repair UV-induced cyclobutane pyrimidine dimer (CPD) lesio...
- Epigenetic silencing of the oncogenic miR-17-92 cluster during PU.1-directed macrophage differentiation
[作者：Pospisil, V; Vargova, K; Kokavec, J; Rybarova, J; Savvulidi, F; Jonasova, A; Necas, E; Zavadil, J; Laslo, P; Stopka, T,期刊：EMBO journal, 页码：4450-4464 , 文章类型： Article，,卷期：2011年30-21]
- The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel...
- BAX inhibitor-1 regulates autophagy by controlling the IRE1 alpha branch of the unfolded protein response
[作者：Castillo, K; Rojas-Rivera, D; Lisbona, F; Caballero, B; Nassif, M; Court, FA; Schuck, S; Ibar, C; Walter, P; Sierralta, J; Glavic, A; Hetz, C,期刊：EMBO journal, 页码：4465-4478 , 文章类型： Article，,卷期：2011年30-21]
- Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER)...
- Structural basis for cell surface patterning through NetrinG-NGL interactions
[作者：Seiradake, E; Coles, CH; Perestenko, PV; Harlos, K; McIlhinney, RAJ; Aricescu, AR; Jones, EY,期刊：EMBO journal, 页码：4479-4488 , 文章类型： Article，,卷期：2011年30-21]
- Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the s...
- Transcription factor Dlx2 protects from TGF beta-induced cell-cycle arrest and apoptosis
[作者：Yilmaz, M; Maass, D; Tiwari, N; Waldmeier, L; Schmidt, P; Lehembre, F; Christofori, G,期刊：EMBO journal, 页码：4489-4499 , 文章类型： Article，,卷期：2011年30-21]
- Acquiring resistance against transforming growth factor beta (TGF beta)-induced growth inhibition at early stages of carcinogenesis and shifting to TGF beta's tumour-promoting functions at later stages is a pre-requisite...
- Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer
[作者：Yun, JU; Frankenberger, CA; Kuo, WL; Boelens, MC; Eves, EM; Cheng, N; Liang, H; Li, WH; Ishwaran, H; Minn, AJ; Rosner, MR,期刊：EMBO journal, 页码：4500-4514 , 文章类型： Article，,卷期：2011年30-21]
- Tumour metastasis suppressors are inhibitors of metastasis but their mechanisms of action are generally not understood. We previously showed that the suppressor Raf kinase inhibitory protein (RKIP) inhibits breast tumour...
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