- Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex
[作者：Helmlinger, D; Marguerat, S; Villen, J; Swaney, DL; Gygi, SP; Bahler, J; Winston, F,期刊：EMBO journal, 页码：2843-2852 , 文章类型： Article，,卷期：2011年30-14]
- The SAGA complex is a conserved, multifunctional coactivator that has broad roles in eukaryotic transcription. Previous studies suggested that Tra1, the largest SAGA component, is required either for SAGA assembly or for...
- Autoregulation of Parkin activity through its ubiquitin-like domain
[作者：Chaugule, VK; Burchell, L; Barber, KR; Sidhu, A; Leslie, SJ; Shaw, GS; Walden, H,期刊：EMBO journal, 页码：2853-2867 , 文章类型： Article，,卷期：2011年30-14]
- Parkin is an E3-ubiquitin ligase belonging to the RBR (RING-InBetweenRING-RING family), and is involved in the neurodegenerative disorder Parkinson's disease. Autosomal recessive juvenile Parkinsonism, which is one of th...
- Shugoshin is a Mad1/Cdc20-like interactor of Mad2
[作者：Orth, M; Mayer, B; Rehm, K; Rothweiler, U; Heidmann, D; Holak, TA; Stemmann, O,期刊：EMBO journal, 页码：2868-2880 , 文章类型： Article，,卷期：2011年30-14]
- Mammalian centromeric cohesin is protected from phosphorylation-dependent displacement in mitotic prophase by shugoshin-1 (Sgo1), while shugoshin-2 (Sgo2) protects cohesin from separase-dependent cleavage in meiosis I. I...
- An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus
[作者：Etherton, MR; Tabuchi, K; Sharma, M; Ko, J; Sudhof, TC,期刊：EMBO journal, 页码：2908-2919 , 文章类型： Article，,卷期：2011年30-14]
- Neuroligins are evolutionarily conserved postsynaptic cell-adhesion molecules that function, at least in part, by forming trans-synaptic complexes with presynaptic neurexins. Different neuroligin isoforms perform diverse...
- FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
[作者：Yamagishi, S; Hampel, F; Hata, K; del Toro, D; Schwark, M; Kvachnina, E; Bastmeyer, M; Yamashita, T; Tarabykin, V; Klein, R; Egea, J,期刊：EMBO journal, 页码：2920-2933 , 文章类型： Article，,卷期：2011年30-14]
- Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A-Unc5D). Mouse genetic analysis of selected members of the Unc5 family, however, revealed essential functions independent of...
- Identity, regulation and in vivo function of gut NKp46(+)ROR gamma t(+) and NKp46(+)ROR gamma t(-) lymphoid cells
[作者：Reynders, A; Yessaad, N; Manh, TPV; Dalod, M; Fenis, A; Aubry, C; Nikitas, G; Escaliere, B; Renauld, JC; Dussurget, O; Cossart, P; Lecuit, M; Vivier, E; Tomasello, E,期刊：EMBO journal, 页码：2934-2947 , 文章类型： Article，,卷期：2011年30-14]
- The gut is a major barrier against microbes and encloses various innate lymphoid cells (ILCs), including two subsets expressing the natural cytotoxicity receptor NKp46. A subset of NKp46(+) cells expresses retinoic acid ...
- An infrequent molecular ruler controls flagellar hook length in Salmonella enterica
[作者：Erhardt, M; Singer, HM; Wee, DH; Keener, JP; Hughes, KT,期刊：EMBO journal, 页码：2948-2961 , 文章类型： Article，,卷期：2011年30-14]
- The bacterial flagellum consists of a long external filament connected to a membrane-embedded basal body at the cell surface by a short curved structure called the hook. In Salmonella enterica, the hook extends 55 nm fro...
- Architecture of the flagellar rotor
[作者：Paul, K; Gonzalez-Bonet, G; Bilwes, AM; Crane, BR; Blair, D,期刊：EMBO journal, 页码：2962-2971 , 文章类型： Article，,卷期：2011年30-14]
- Rotation and switching of the bacterial flagellum depends on a large rotor-mounted protein assembly composed of the proteins FliG, FliM and FliN, with FliG most directly involved in rotation. The crystal structure of a c...
- Structural diversity of bacterial flagellar motors
[作者：Chen, SY; Beeby, M; Murphy, GE; Leadbetter, JR; Hendrixson, DR; Briegel, A; Li, Z; Shi, J; Tocheva, EI; Muller, A; Dobro, MJ; Jensen, GJ,期刊：EMBO journal, 页码：2972-2981 , 文章类型： Article，,卷期：2011年30-14]
- The bacterial flagellum is one of nature's most amazing and well-studied nanomachines. Its cell-wall-anchored motor uses chemical energy to rotate a microns-long filament and propel the bacterium towards nutrients and aw...
- The nuclear RNA polymerase II surveillance system targets polymerase III transcripts (vol 30, pg 1790, 2011)
[作者：Wlotzka, W; Kudla, G; Granneman, S; Tollervey, D,期刊：EMBO journal, 页码：2982-2982 , 文章类型： Correction，,卷期：2011年30-14]
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- How to split up: lessons from mitochondria
[作者：Dikov, D; Reichert, AS,期刊：EMBO journal, 页码：2751-2753 , 文章类型： Editorial Material，,卷期：2011年30-14]
- Mitochondria are remarkably dynamic organelles undergoing frequent fusion and fission events. Impairment thereof is linked to numerous neurodegenerative disorders and dysregulation of apoptosis. The principal players med...
- Tonight, the same old, deadly programme: BH3-only proteins, mitochondria and yeast
[作者：Oettinghaus, B; Frank, S; Scorrano, L,期刊：EMBO journal, 页码：2754-2756 , 文章类型： Editorial Material，,卷期：2011年30-14]
- Apoptosis is a type of programmed cell death (PCD) conserved among metazoans and crucial for the development and homeostasis of tissues in multicellular organisms. Lower unicellular eukaryotes like yeast would thus have ...
- Policing Parkin with a UblD
[作者：Liu, F; Walters, KJ,期刊：EMBO journal, 页码：2757-2758 , 文章类型： Editorial Material，,卷期：2011年30-14]
- Mutations in the E3 ubiquitin ligase Parkin are linked to Autosomal Recessive Juvenile Parkinsonism, including a cluster of pathogenic mutations in exon 2 that gives rise to Parkin's N-terminal ubiquitin-like domain (Ubl...
- A mad partner for Shugoshin in meiosis
[作者：Yu, HT,期刊：EMBO journal, 页码：2759-2761 , 文章类型： Editorial Material，,卷期：2011年30-14]
- The centromeric cohesin protector Shugoshin (Sgo) and the spindle checkpoint protein Mad2 are known to act in distinct pathways for ensuring accurate chromosome segregation during eukaryotic cell division. In this issue ...
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