- Mitochondria breathe for autophagy
[作者：Okamoto, K,期刊：EMBO journal, 页码：2095-2096 , 文章类型： Editorial Material，,卷期：2011年30-11]
- Proper mitochondrial structure and function are established by continuous cycles of fusion and fission, and a unidirectional pathway of autophagy-mediated degradation. In this issue of The EMBO Journal, Graef and Nunnari...
- Arp you ready for actin in the nucleus?
[作者：Kast, DJ; Dominguez, R,期刊：EMBO journal, 页码：2097-2098 , 文章类型： Editorial Material，,卷期：2011年30-11]
- Actin and actin-related proteins (Arps) are critical components of chromatin remodelling and modifying complexes, where they are commonly found in pairs. Yet, little is known about their role in these complexes. In this ...
- P53 conformational switching for selectivity may reveal a general solution for specific DNA binding
[作者：Tubbs, JL; Tainer, JA,期刊：EMBO journal, 页码：2099-2100 , 文章类型： Editorial Material，,卷期：2011年30-11]
- DNA-binding proteins are integral members of the cell community, having indispensable roles in critical DNA processes such as gene expression regulation, replication, transcription, and genomic maintenance. Yet, how thes...
- LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-kappa B activation
[作者：Verweij, FJ; van Eijndhoven, MAJ; Hopmans, ES; Vendrig, T; Wurdinger, T; Cahir-McFarland, E; Kieff, E; Geerts, D; van der Kant, R; Neefjes, J; Middeldorp, JM; Pegtel, DM,期刊：EMBO journal, 页码：2115-2129 , 文章类型： Article，,卷期：2011年30-11]
- The ubiquitous Epstein Barr virus (EBV) exploits human B-cell development to establish a persistent infection in similar to 90% of the world population. Constitutive activation of NF-kappa B by the viral oncogene latent ...
- Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin
[作者：Fenn, S; Breitsprecher, D; Gerhold, CB; Witte, G; Faix, J; Hopfner, KP,期刊：EMBO journal, 页码：2153-2166 , 文章类型： Article，,卷期：2011年30-11]
- Nuclear actin and actin-related proteins (Arps) are integral components of various chromatin-remodelling complexes. Actin in such nuclear assemblies does not form filaments but associates in defined complexes, for instan...
- An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificity
[作者：Petty, TJ; Emamzadah, S; Costantino, L; Petkova, I; Stavridi, ES; Saven, JG; Vauthey, E; Halazonetis, TD,期刊：EMBO journal, 页码：2167-2176 , 文章类型： Article，,卷期：2011年30-11]
- The p53 tumour suppressor gene, the most frequently mutated gene in human cancer, encodes a transcription factor that contains sequence-specific DNA binding and homo-tetramerization domains. Interestingly, the affinities...
- USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1
[作者：Zhang, XN; Berger, FG; Yang, JH; Lu, XB,期刊：EMBO journal, 页码：2177-2189 , 文章类型： Article，,卷期：2011年30-11]
- Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF-BP1. The ubiquitination process is reversible via deubiquitinating e...
- Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation
[作者：Ura, H; Murakami, K; Akagi, T; Kinoshita, K; Yamaguchi, S; Masui, S; Niwa, H; Koide, H; Yokota, T,期刊：EMBO journal, 页码：2190-2204 , 文章类型： Article，,卷期：2011年30-11]
- Transcription factors and epigenetic modulators are involved in the maintenance of self-renewal in embryonic stem (ES) cells. Here, we demonstrate the existence of a regulatory loop in ES cells between Sox2, an indispens...
- CRM1 controls the composition of nucleoplasmic pre-snoRNA complexes to licence them for nucleolar transport
[作者：Pradet-Balade, B; Girard, C; Boulon, S; Paul, C; Azzag, K; Bordonne, R; Bertrand, E; Verheggen, C,期刊：EMBO journal, 页码：2205-2218 , 文章类型： Article，,卷期：2011年30-11]
- Transport of C/D snoRNPs to nucleoli involves nuclear export factors. In particular, CRM1 binds nascent snoRNPs, but its precise role remains unknown. We show here that both CRM1 and nucleocytoplasmic trafficking are req...
- Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53
[作者：Ugalde, AP; Ramsay, AJ; de la Rosa, J; Varela, I; Marino, G; Cadinanos, J; Lu, J; Freije, JMP; Lopez-Otin, C,期刊：EMBO journal, 页码：2219-2232 , 文章类型： Article，,卷期：2011年30-11]
- Aging is a multifactorial process that affects most of the biological functions of the organism and increases susceptibility to disease and death. Recent studies with animal models of accelerated aging have unveiled some...
- Differential control of Eg5-dependent centrosome EMBO separation by Plk1 and Cdk1
[作者：Smith, E; Hegarat, N; Vesely, C; Roseboom, I; Larch, C; Streicher, H; Straatman, K; Flynn, H; Skehel, M; Hirota, T; Kuriyama, R; Hochegger, H,期刊：EMBO journal, 页码：2233-2245 , 文章类型： Article，,卷期：2011年30-11]
- Cyclin-dependent kinase 1 (Cdk1) is thought to trigger centrosome separation in late G2 phase by phosphorylating the motor protein Eg5 at Thr927. However, the precise control mechanism of centrosome separation remains to...
- Conjugal plasmid transfer in Streptomyces resembles bacterial chromosome segregation by FtsK/SpoIIIE
[作者：Vogelmann, J; Ammelburg, M; Finger, C; Guezguez, J; Linke, D; Flotenmeyer, M; Stierhof, YD; Wohlleben, W; Muth, G,期刊：EMBO journal, 页码：2246-2254 , 文章类型： Article，,卷期：2011年30-11]
- Conjugation is a major route of horizontal gene transfer, the driving force in the evolution of bacterial genomes. Antibiotic producing soil bacteria of the genus Streptomyces transfer DNA in a unique process involving a...
- Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
[作者：Kumar, S; Rezaei-Ghaleh, N; Terwel, D; Thal, DR; Richard, M; Hoch, M; Mc Donald, JM; Wullnner, U; Glebov, K; Heneka, MT; Walsh, DM; Zweckstetter, M; Walter, J,期刊：EMBO journal, 页码：2255-2265 , 文章类型： Article，,卷期：2011年30-11]
- Alzheimer's disease (AD) is the most common form of dementia and associated with progressive deposition of amyloid beta-peptides (A beta) in the brain. A beta derives by sequential proteolytic processing of the amyloid p...
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