- Actin up for Hippo
[作者：Richardson, HE,期刊：EMBO journal, 页码：2307-2309 , 文章类型： Editorial Material，,卷期：2011年30-12]
- The Hippo (Hpo) signalling pathway is an evolutionarily conserved pathway controlling tissue growth, but its upstream inputs remain poorly understood. In this issue of The EMBO Journal, Sansores-Garcia et al (2011) repor...
- Modulating F-actin organization induces organ growth by affecting the Hippo pathway
[作者：Sansores-Garcia, L; Bossuyt, W; Wada, KI; Yonemura, S; Tao, CY; Sasaki, H; Halder, G,期刊：EMBO journal, 页码：2325-2335 , 文章类型： Article，,卷期：2011年30-12]
- The Hippo tumour suppressor pathway is a conserved signalling pathway that controls organ size. The core of the Hpo pathway is a kinase cascade, which in Drosophila involves the Hpo and Warts kinases that negatively regu...
- The oligomeric state sets GABA(B) receptor signalling efficacy
[作者：Comps-Agrar, L; Kniazeff, J; Norskov-Lauritsen, L; Maurel, D; Gassmann, M; Gregor, N; Prezeau, L; Bettler, B; Durroux, T; Trinquet, E; Pin, JP,期刊：EMBO journal, 页码：2336-2349 , 文章类型： Article，,卷期：2011年30-12]
- G protein-coupled receptors (GPCRs) have key roles in cell-cell communication. Recent data suggest that these receptors can form large complexes, a possibility expected to expand the complexity of this regulatory system....
- AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II
[作者：Rozenfeld, R; Gupta, A; Gagnidze, K; Lim, MP; Gomes, I; Lee-Ramos, D; Nieto, N; Devi, LA,期刊：EMBO journal, 页码：2350-2363 , 文章类型： Article，,卷期：2011年30-12]
- The mechanism of G protein-coupled receptor (GPCR) signal integration is controversial. While GPCR assembly into hetero-oligomers facilitates signal integration of different receptor types, cross-talk between G alpha i- ...
- The RSC chromatin remodelling ATPase translocates DNA with high force and small step size
[作者：Sirinakis, G; Clapier, CR; Gao, Y; Viswanathan, R; Cairns, BR; Zhang, YL,期刊：EMBO journal, 页码：2364-2372 , 文章类型： Article，,卷期：2011年30-12]
- ATP-dependent chromatin remodelling complexes use the energy of ATP hydrolysis to reposition and reconfigure nucleosomes. Despite their diverse functions, all remodellers share highly conserved ATPase domains, many shown...
- The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells
[作者：McManus, S; Ebert, A; Salvagiotto, G; Medvedovic, J; Sun, Q; Tamir, I; Jaritz, M; Tagoh, H; Busslinger, M,期刊：EMBO journal, 页码：2388-2404 , 文章类型： Article，,卷期：2011年30-12]
- Pax5 is a critical regulator of B-cell commitment. Here, we identified direct Pax5 target genes by streptavidin-mediated ChIP-chip analysis of pro-B cells expressing in vivo biotinylated Pax5. By binding to promoters and...
- Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth
[作者：Chen, Z; Zhang, CP; Wu, DY; Chen, HY; Rorick, A; Zhang, XT; Wang, QB,期刊：EMBO journal, 页码：2405-2419 , 文章类型： Article，,卷期：2011年30-12]
- The UBE2C oncogene is overexpressed in many types of solid tumours including the lethal castration-resistant prostate cancer (CRPC). The underlying mechanisms causing UBE2C gene overexpression in CRPC are not fully under...
- Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing
[作者：van Nues, RW; Granneman, S; Kudla, G; Sloan, KE; Chicken, M; Tollervey, D; Watkins, NJ,期刊：EMBO journal, 页码：2420-2430 , 文章类型： Article，,卷期：2011年30-12]
- 2'-O-methylation of eukaryotic ribosomal RNA (r)RNA, essential for ribosome function, is catalysed by box C/D small nucleolar (sno)RNPs. The RNA components of these complexes (snoRNAs) contain one or two guide sequences,...
- RNA polymerase II kinetics in polo polyadenylation signal selection
[作者：Pinto, PAB; Henriques, T; Freitas, MO; Martins, T; Domingues, RG; Wyrzykowska, PS; Coelho, PA; Carmo, AM; Sunkel, CE; Proudfoot, NJ; Moreira, A,期刊：EMBO journal, 页码：2431-2444 , 文章类型： Article，,卷期：2011年30-12]
- Regulated alternative polyadenylation is an important feature of gene expression, but how gene transcription rate affects this process remains to be investigated. polo is a cell-cycle gene that uses two poly(A) signals i...
- eIF2A mediates translation of hepatitis C viral mRNA under stress conditions
[作者：Kim, JH; Park, SM; Park, JH; Keum, SJ; Jang, SK,期刊：EMBO journal, 页码：2454-2464 , 文章类型： Article，,卷期：2011年30-12]
- Translation of most mRNAs is suppressed under stress conditions. Phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 (eIF2), which delivers initiator tRNA (Met-tRNA(i)) to the P site of the...
- Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling
[作者：Yun, HJ; Yoon, JH; Lee, JK; Noh, KT; Yoon, KW; Oh, SP; Oh, HJ; Chae, JS; Hwang, SG; Kim, EH; Maul, GG; Lim, DS; Choi, EJ,期刊：EMBO journal, 页码：2465-2476 , 文章类型： Article，,卷期：2011年30-12]
- Microglia, the resident macrophages of the mammalian central nervous system, migrate to sites of tissue damage or infection and become activated. Although the persistent secretion of inflammatory mediators by the activat...
- Skeletal myosin light chain kinase regulates skeletal myogenesis by phosphorylation of MEF2C
[作者：Al Madhoun, AS; Mehta, V; Li, G; Figeys, D; Wiper-Bergeron, N; Skerjanc, IS,期刊：EMBO journal, 页码：2477-2489 , 文章类型： Article，,卷期：2011年30-12]
- The MEF2 factors regulate transcription during cardiac and skeletal myogenesis. MEF2 factors establish skeletal muscle commitment by amplifying and synergizing with MyoD. While phosphorylation is known to regulate MEF2 f...
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