- 5-Fluorouracil derivatives: a patent review
[作者:Alvarez, P; Marchal, JA; Boulaiz, H; Carrillo, E; Velez, C; Rodriguez-Serrano, F; Melguizo, C; Prados, J; Madeddu, R; Aranega, A,期刊:Expert Opinion on Therapeutic Patents, 页码:107-123 , 文章类型: Review,,卷期:2012年22-2]
- Introduction: The fluorinated analog of uracil 5-FU is an antimetabolite, active against a wide range of solid tumors. The main mechanism of action consists in interfering with DNA synthesis and mRNA translation. However...
- Protein tyrosine phosphatase inhibitors: a patent review (2002-2011)
[作者:Sobhia, ME; Paul, S; Shinde, R; Potluri, M; Gundam, V; Kaur, A; Haokip, T,期刊:Expert Opinion on Therapeutic Patents, 页码:125-153 , 文章类型: Review,,卷期:2012年22-2]
- Introduction: The protein tyrosine phosphatases (PTPases or PTPs) are highly conserved phosphatases that regulate the tyrosine phosphorylation and consequently, the cellular functions. Protein tyrosine phosphorylation is...
- Recent advances in the development of cinnamic-like derivatives as antituberculosis agents
[作者:De, P; De, K; Veau, D; Bedos-Belval, F; Chassaing, S; Baltas, M,期刊:Expert Opinion on Therapeutic Patents, 页码:155-168 , 文章类型: Review,,卷期:2012年22-2]
- Introduction: The high susceptibility of human immunodeficiency virus-infected people to tuberculosis (TB), the emergence of multi-drug-resistant (MDR-TB) strains and extensively drug-resistant (XDR-TB) ones, has brought...
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