- The Molecular Basis of Acid Insensitivity in the African Naked Mole-Rat
[作者:Smith, ESJ; Omerbasic, D; Lechner, SG; Anirudhan, G; Lapatsina, L; Lewin, GR,期刊:Science, 页码:1557-1560 , 文章类型: Article,,卷期:2011年334-6062]
- Acid evokes pain by exciting nociceptors; the acid sensors are proton-gated ion channels that depolarize neurons. The naked mole-rat (Heterocephalus glaber) is exceptional in its acid insensitivity, but acid sensors (aci...
- Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
[作者:Kiss, EA; Vonarbourg, C; Kopfmann, S; Hobeika, E; Finke, D; Esser, C; Diefenbach, A,期刊:Science, 页码:1561-1565 , 文章类型: Article,,卷期:2011年334-6062]
- Innate lymphoid cells (ILC) expressing the transcription factor ROR gamma t induce the postnatal formation of intestinal lymphoid follicles and regulate intestinal homeostasis. ROR gamma t(+) ILC express the aryl hydroca...
- RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release
[作者:Liu, KSY; Siebert, M; Mertel, S; Knoche, E; Wegener, S; Wichmann, C; Matkovic, T; Muhammad, K; Depner, H; Mettke, C; Buckers, J; Hell, SW; Muller, M; Davis, GW; Schmitz, D; Sigrist, SJ,期刊:Science, 页码:1565-1569 , 文章类型: Article,,卷期:2011年334-6062]
- The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified. AZ-associated protein s...
- Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice
[作者:Michaud, M; Martins, I; Sukkurwala, AQ; Adjemian, S; Ma, YT; Pellegatti, P; Shen, SS; Kepp, O; Scoazec, M; Mignot, G; Rello-Varona, S; Tailler, M; Menger, L; Vacchelli, E; Galluzzi, L; Ghiringhelli, F; di Virgilio, F; Zitvogel, L; Kroemer, G,期刊:Science, 页码:1573-1577 , 文章类型: Article,,卷期:2011年334-6062]
- Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we demonstrate that autophagy, which is often disabled in cancer, is di...
- Uninformed Individuals Promote Democratic Consensus in Animal Groups
[作者:Couzin, ID; Ioannou, CC; Demirel, G; Gross, T; Torney, CJ; Hartnett, A; Conradt, L; Levin, SA; Leonard, NE,期刊:Science, 页码:1578-1580 , 文章类型: Article,,卷期:2011年334-6062]
- Conflicting interests among group members are common when making collective decisions, yet failure to achieve consensus can be costly. Under these circumstances individuals may be susceptible to manipulation by a strongl...
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