- Loss of Scribble causes cell competition in mammalian cells
[作者:Norman, M; Wisniewska, KA; Lawrenson, K; Garcia-Miranda, P; Tada, M; Kajita, M; Mano, H; Ishikawa, S; Ikegawa, M; Shimada, T; Fujita, Y,期刊:Journal of cell science, 页码:59-66 , 文章类型: Article,,卷期:2012年125-1]
- In Drosophila, normal and transformed cells compete with each other for survival in a process called cell competition. However, it is not known whether comparable phenomena also occur in mammals. Scribble is a tumor supp...
- MicroRNAs and their roles in aging
[作者:Smith-Vikos, T; Slack, FJ,期刊:Journal of cell science, 页码:7-17 , 文章类型: Article,,卷期:2012年125-1]
- MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial base-pair complementarity with their target genes, resulting in post-transcriptional repression of gene expression. The role of miRN...
- Cdt1p, through its interaction with Mcm6p, is required for the formation, nuclear accumulation and chromatin loading of the MCM complex
[作者:Wu, RT; Wang, JF; Liang, C,期刊:Journal of cell science, 页码:209-219 , 文章类型: Article,,卷期:2012年125-1]
- Regulation of DNA replication initiation is essential for the faithful inheritance of genetic information. Replication initiation is a multi-step process involving many factors including ORC, Cdt1p, Mcm2-7p and other pro...
- Mutational analysis supports a core role for Drosophila alpha-Catenin in adherens junction function
[作者:Sarpal, R; Pellikka, M; Patel, RR; Hui, FYW; Godt, D; Tepass, U,期刊:Journal of cell science, 页码:233-245 , 文章类型: Article,,卷期:2012年125-1]
- alpha-catenin associates the cadherin-catenin complex with the actin cytoskeleton. a-catenin binds to beta-catenin, which links it to the cadherin cytoplasmic tail, and F-actin, but also to a multitude of actin-associate...
- Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability
[作者:Kumareswaran, R; Ludkovski, O; Meng, A; Sykes, J; Pintilie, M; Bristow, RG,期刊:Journal of cell science, 页码:189-199 , 文章类型: Article,,卷期:2012年125-1]
- Hypoxic cells have been linked to genetic instability and tumor progression. However, little is known about the exact relationship between DNA repair and genetic instability in hypoxic cells. We therefore tested whether ...
- CRSBP-1/LYVE-1 ligands disrupt lymphatic intercellular adhesion by inducing tyrosine phosphorylation and internalization of VE-cadherin (vol 124, pg 1231, 2011)
[作者:Hou, WH; Liu, IH; Tsai, CC; Johnson, FE; Huang, SS; Huang, JS,期刊:Journal of cell science, 页码:246-246 , 文章类型: Correction,,卷期:2012年125-1]
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- TOR complex 2 (TORC2) in Dictyostelium suppresses phagocytic nutrient capture independently of TORC1-mediated nutrient sensing
[作者:Rosel, D; Khurana, T; Majithia, A; Huang, XL; Bhandari, R; Kimmel, AR,期刊:Journal of cell science, 页码:37-48 , 文章类型: Article,,卷期:2012年125-1]
- The TOR protein kinase functions in two distinct complexes, TOR complex 1 (TORC1) and 2 (TORC2). TORC1 is required for growth in response to growth factors, nutrients and the cellular energy state; TORC2 regulates AKT si...
- Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair
[作者:Elliott, CG; Wang, J; Guo, XL; Xu, SW; Eastwood, M; Guan, JJ; Leask, A; Conway, SJ; Hamilton, DW,期刊:Journal of cell science, 页码:121-132 , 文章类型: Article,,卷期:2012年125-1]
- The matricellular protein periostin is expressed in the skin. Although periostin has been hypothesized to contribute to dermal homeostasis and repair, this has not been directly tested. To assess the contribution of peri...
- Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP
[作者:Park, J; Sung, JY; Park, J; Song, WJ; Chang, S; Chung, KC,期刊:Journal of cell science, 页码:67-80 , 文章类型: Article,,卷期:2012年125-1]
- Neural Wiskott-Aldrich syndrome protein (N-WASP) is involved in tight regulation of actin polymerization and dynamics. N-WASP activity is regulated by intramolecular interaction, binding to small GTPases and tyrosine pho...
- Quantitative mapping of averaged focal adhesion dynamics in migrating cells by shape normalization
[作者:Mohl, C; Kirchgessner, N; Schafer, C; Hoffmann, B; Merkel, R,期刊:Journal of cell science, 页码:155-165 , 文章类型: Article,,卷期:2012年125-1]
- The spatially ordered formation and disassembly of focal adhesions is a basic requirement for effective cell locomotion. Because focal adhesions couple the contractile actin-myosin network to the substrate, their distrib...
- Regulation of local expression of cell adhesion and motility-related mRNAs in breast cancer cells by IMP1/ZBP1
[作者:Gu, W; Katz, Z; Wu, B; Park, HY; Li, DL; Lin, S; Wells, AL; Singer, RH,期刊:Journal of cell science, 页码:81-91 , 文章类型: Article,,卷期:2012年125-1]
- Metastasis involves tumor cell detachment from the primary tumor, and acquisition of migratory and invasive capabilities. These capabilities are mediated by multiple events, including loss of cell-cell contact, an increa...
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