- Nitric Oxide Sustains Long-Term Skeletal Muscle Regeneration by Regulating Fate of Satellite Cells Via Signaling Pathways Requiring Vangl2 and Cyclic GMP
[作者:Buono, R; Vantaggiato, C; Pisa, V; Azzoni, E; Bassi, MT; Brunelli, S; Sciorati, C; Clementi, E,期刊:Stem Cells, 页码:197-209 , 文章类型: Article,,卷期:2012年30-2]
- Satellite cells are myogenic precursors that proliferate, activate, and differentiate on muscle injury to sustain the regenerative capacity of adult skeletal muscle; in this process, they self-renew through the return to...
- Characterization and Function of Histamine Receptors in Human Bone Marrow Stromal Cells
[作者:Nemeth, K; Wilson, T; Rada, B; Parmelee, A; Mayer, B; Buzas, E; Falus, A; Key, S; Masszi, T; Karpati, S; Mezey, E,期刊:Stem Cells, 页码:222-231 , 文章类型: Article,,卷期:2012年30-2]
- There are several clinical trials worldwide using bone marrow stromal cells (BMSCs) as a cellular therapy to modulate immune responses in patients suffering from various inflammatory conditions. A deeper understanding of...
- Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
[作者:Bjornson, CRR; Cheung, TH; Liu, L; Tripathi, PV; Steeper, KM; Rando, TA,期刊:Stem Cells, 页码:232-242 , 文章类型: Article,,卷期:2012年30-2]
- Satellite cells (SCs) are myogenic stem cells found in skeletal muscle that function to repair tissue damaged by injury or disease. SCs are quiescent at rest, although the signaling pathways required to maintain quiescen...
- A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State
[作者:Mourikis, P; Sambasivan, R; Castel, D; Rocheteau, P; Bizzarro, V; Tajbakhsh, S,期刊:Stem Cells, 页码:243-252 , 文章类型: Article,,卷期:2012年30-2]
- Notch signaling plays a key role in virtually all tissues and organs in metazoans; however, limited examples are available for the regulatory role of this pathway in adult quiescent stem cells. We performed a temporal an...
- Barx2 Is Expressed in Satellite Cells and Is Required for Normal Muscle Growth and Regeneration
[作者:Meech, R; Gonzalez, KN; Barro, M; Gromova, A; Zhuang, LZ; Hulin, JA; Makarenkova, HP,期刊:Stem Cells, 页码:253-265 , 文章类型: Article,,卷期:2012年30-2]
- Muscle growth and regeneration are regulated through a series of spatiotemporally dependent signaling and transcriptional cascades. Although the transcriptional program controlling myogenesis has been extensively investi...
- Bone Marrow-Derived Mesenchymal Stromal Cells are Attracted by Multiple Myeloma Cell-Produced Chemokine CCL25 and Favor Myeloma Cell Growth in Vitro and In Vivo
[作者:Xu, S; Menu, E; De Becker, A; Van Camp, B; Vanderkerken, K; Van Riet, I,期刊:Stem Cells, 页码:266-279 , 文章类型: Article,,卷期:2012年30-2]
- Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells that are predominantly localized in the bone marrow (BM). Mesenchymal stromal cells (MSCs) give rise to most BM stromal cells that interact ...
- Epithelial and Mesenchymal Subpopulations Within Normal Basal Breast Cell Lines Exhibit Distinct Stem Cell/Progenitor Properties
[作者:Sarrio, D; Franklin, CK; Mackay, A; Reis, JS; Isacke, CM,期刊:Stem Cells, 页码:292-303 , 文章类型: Article,,卷期:2012年30-2]
- It has been proposed that epithelialmesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features, and that the presence of EMT characteristics in claudin-low breast tumors...
- The Crosstalk Between Transforming Growth Factor-ss 1 and Delta Like-1 Mediates Early Chondrogenesis During Embryonic Endochondral Ossification
[作者:Taipaleenmaki, H; Harkness, L; Chen, L; Larsen, KH; Saamanen, AM; Kassem, M; Abdallah, BM,期刊:Stem Cells, 页码:304-313 , 文章类型: Article,,卷期:2012年30-2]
- Delta like-1 (Dlk1)/preadipocyte factor-1 (Pref-1)/fetal antigen-1 (FA1) is a novel surface marker for embryonic chondroprogenitor cells undergoing lineage progression from proliferation to prehypertrophic stages. Howeve...
- Human Neural Stem Cell Tropism to Metastatic Breast Cancer
[作者:Zhao, DH; Najbauer, J; Annala, AJ; Garcia, E; Metz, MZ; Gutova, M; Polewski, MD; Gilchrist, M; Glackin, CA; Kim, SU; Aboody, KS,期刊:Stem Cells, 页码:314-325 , 文章类型: Article,,卷期:2012年30-2]
- Metastasis to multiple organs is the primary cause of mortality in breast cancer patients. The poor prognosis for patients with metastatic breast cancer and toxic side effects of currently available treatments necessitat...
- Stem Cell Media Culture of Melanoma Results in the Induction of a Nonrepresentative Neural Expression Profile
[作者:Anaka, M; Freyer, C; Gedye, C; Caballero, O; Davis, ID; Behren, A; Cebon, J,期刊:Stem Cells, 页码:336-343 , 文章类型: Article,,卷期:2012年30-2]
- The ability of cell lines to accurately represent cancer is a major concern in preclinical research. Culture of glioma cells as neurospheres in stem cell media (SCM) has been shown to better represent the genotype and ph...
- Aldehyde Dehydrogenase Activity Is a Biomarker of Primitive Normal Human Mammary Luminal Cells
[作者:Eirew, P; Kannan, N; Knapp, DJHF; Vaillant, F; Emerman, JT; Lindeman, GJ; Visvader, JE; Eaves, CJ,期刊:Stem Cells, 页码:344-348 , 文章类型: Article,,卷期:2012年30-2]
- Elevated aldehyde dehydrogenase (ALDH) expression/activity has been identified as an important biomarker of primitive cells in various normal and malignant human tissues. Here we examined the level and type of ALDH expre...
- Guided Migration of Neural Stem Cells Derived from Human Embryonic Stem Cells by an Electric Field
[作者:Feng, JF; Liu, J; Zhang, XZ; Zhang, L; Jiang, JY; Nolta, J; Zhao, M,期刊:Stem Cells, 页码:349-355 , 文章类型: Article,,卷期:2012年30-2]
- Small direct current (DC) electric fields (EFs) guide neurite growth and migration of rodent neural stem cells (NSCs). However, this could be species dependent. Therefore, it is critical to investigate how human NSCs (hN...
- In vitro models
[作者:Mather, JP,期刊:Stem Cells, 页码:95-99 , 文章类型: Review,,卷期:2012年30-2]
- The current resurgence of interest in the cancer stem cell (CSC) hypothesis as possibly providing a unifying theory of cancer biology is fueled by the growing body of work on normal adult tissue stem cells and the promis...
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