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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer [作者：JENKINS LISA M MILLER; OTT DAVID E; HAYASHI RYO; COREN LORI V; WANG DEYUN; XU QUN; SCHITO MARCO L; INMAN JOHN K; APPELLA DANIEL H; APPELLA ETTORE,期刊：NATURE CHEMICAL BIOLOGY, 页码：887-889 , 文章类型： Article，,卷期：2010年6-12] The zinc fingers of the HIV-1 nucleocapsid protein, NCp7, are prime targets for antiretroviral therapeutics. Here we show that S-acyl-2-mercaptobenzamide thioester (SAMT) chemotypes inhibit HIV by modifying the NCp7 regi... Microscopic rotary mechanism of ion translocation in the F-0 complex of ATP synthases [作者：POGORYELOV DENYS; KRAH ALEXANDER; LANGER JULIAN D; YILDIZ OEZKAN; FARALDOGOMEZ JOSE D; MEIER THOMAS,期刊：NATURE CHEMICAL BIOLOGY, 页码：891-899 , 文章类型： Article，,卷期：2010年6-12] The microscopic mechanism of coupled c-ring rotation and ion translocation in F1F0-ATP synthases is unknown. Here we present conclusive evidence supporting the notion that the ability of c-rings to rotate within the F-0 ... The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase [作者：SHARMA SANDEEP K; DE LOS RIOS PAOLO; CHRISTEN PHILIPP; LUSTIG ARIEL; GOLOUBINOFF PIERRE,期刊：NATURE CHEMICAL BIOLOGY, 页码：914-920 , 文章类型： Article，,卷期：2010年6-12] Hsp70-Hsp40-NEF and possibly Hsp100 are the only known molecular chaperones that can use the energy of ATP to convert stably pre-aggregated polypeptides into natively refolded proteins. However, the kinetic parameters an... Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins [作者：HOFFSTROM BENJAMIN G; KAPLAN ANNA; LETSO REKA; SCHMID RALF S; TURMEL GREGORY J; LO DONALD C; STOCKWELL BRENT R,期刊：NATURE CHEMICAL BIOLOGY, 页码：900-906 , 文章类型： Article，,卷期：2010年6-12] A hallmark of many neurodegenerative diseases is accumulation of misfolded proteins within neurons, leading to cellular dysfunction and cell death. Although several mechanisms have been proposed to link protein misfoldin... Ultrasensitive in situ visualization of active glucocerebrosidase molecules [作者：WITTE MARTIN D; KALLEMEIJN WOUTER W; ATEN JAN; LI KAHYEE; STRIJLAND ANNEKE; DONKERKOOPMAN WILMA E; VAN DEN NIEUWENDIJK ADRIANUS M C H; BLEIJLEVENS BORIS; KRAMER GERTJAN; FLOREA BOGDAN I; HOOIBRINK BEREND; HOLLAK CARLA E M; OTTENHOFF ROELOF; BOOT ROLF G; VAN DER MAREL GIJSBERT A; OVERKLEEFT HERMAN S; AERTS JOHANNES M F G,期刊：NATURE CHEMICAL BIOLOGY, 页码：907-913 , 文章类型： Article，,卷期：2010年6-12] Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exi... Contemplating chemical biology [作者：null,期刊：NATURE CHEMICAL BIOLOGY, 页码：845-845 , 文章类型： Editorial Material，,卷期：2010年6-12] A decade of chemical biology [作者：BUCCI MIRELLA; GOODMAN CATHERINE; SHEPPARD TERRY L,期刊：NATURE CHEMICAL BIOLOGY, 页码：847-854 , 文章类型： Editorial Material，,卷期：2010年6-12] Accessing new chemical space for 'undruggable' targets [作者：DANDAPANI SIVARAMAN; MARCAURELLE LISA A,期刊：NATURE CHEMICAL BIOLOGY, 页码：861-863 , 文章类型： Editorial Material，,卷期：2010年6-12] The synthesis and biological annotation of small molecules from underexplored chemical space will play a central role in the development of drugs for challenging targets currently being identified in frontier areas of bi... RNA epigenetics? [作者：HE CHUAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：863-865 , 文章类型： Editorial Material，,卷期：2010年6-12] Post-transcriptional RNA modifications can be dynamic and might have functions beyond fine-tuning the structure and function of RNA. Understanding these RNA modification pathways and their functions may allow researchers... Informative diagnostics for personalized medicine [作者：BAILEY RYAN C,期刊：NATURE CHEMICAL BIOLOGY, 页码：857-859 , 文章类型： Editorial Material，,卷期：2010年6-12] Some of the most celebrated triumphs of chemical biology are molecularly targeted therapeutics to combat human disease. However, a grand challenge looms as informative diagnostic strategies must be developed to realize t... Transforming biosynthesis into an information science [作者：BAYER TRAVIS S,期刊：NATURE CHEMICAL BIOLOGY, 页码：859-861 , 文章类型： Editorial Material，,卷期：2010年6-12] Engineering biosynthetic pathways to natural products is a challenging endeavor that promises to provide new therapeutics and tools to manipulate biology. Information-guided design strategies and tools could unlock the c... Chassis cells for industrial biochemical production [作者：VICKERS CLAUDIA E; BLANK LARS M; KROEMER JENS O,期刊：NATURE CHEMICAL BIOLOGY, 页码：875-877 , 文章类型： Editorial Material，,卷期：2010年6-12] Hyper-performing whole-cell catalysts are required for the renewable and sustainable production of petrochemical replacements. Chassis cells-self-replicating minimal machines that can be tailored for the production of sp... Chemical transdifferentiation and regenerative medicine [作者：WAGNER BRIDGET K,期刊：NATURE CHEMICAL BIOLOGY, 页码：877-879 , 文章类型： Editorial Material，,卷期：2010年6-12] The ability to alter cell identity with small molecules represents a powerful approach to restore biological function lost because of cellular deficiency. Developing this capability through advances in chemical biology c... CHAPERONES A story of thrift unfolds [作者：BANEYX FRANCOIS; NANNENGA BRENT L,期刊：NATURE CHEMICAL BIOLOGY, 页码：880-881 , 文章类型： News Item，,卷期：2010年6-12] Although members of the Hsp70-DnaK family of heat shock proteins are involved in nearly all aspects of cell physiology, some mechanistic details of their mode of action remain obscure. A new substrate helps establish Dna... MOLECULAR PROBES Getting lucky in the lysosome [作者：GODDARDBORGER ETHAN D; WENNEKES TOM; WITHERS STEPHEN G,期刊：NATURE CHEMICAL BIOLOGY, 页码：881-883 , 文章类型： News Item，,卷期：2010年6-12] Conjugation of a known, mechanism-based glycosidase inhibitor to sensitive fluorophores yielded unexpectedly potent and selective probes for quantifying active lysosomal glucocerebrosidase. These conjugates could prove t... GLYCOBIOLOGY Cellulose squeezes through [作者：ENDLER ANNE; SANCHEZRODRIGUEZ CLARA; PERSSON STAFFAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：883-884 , 文章类型： News Item，,卷期：2010年6-12] The glucose-based polymer cellulose is of great biological and economical importance; however, little is known about how cellulose is synthesized. Now, structural estimates of one of the cellulose-synthesizing subunits i...