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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共14条记录   Chemical decay of an antibiotic inverts selection for resistance [作者：PALMER ADAM C; ANGELINO ELAINE; KISHONY ROY,期刊：NATURE CHEMICAL BIOLOGY, 页码：105-107 , 文章类型： Article，,卷期：2010年6-2] Antibiotics are often unstable and can decay into various compounds with potential biological activities. We found that as tetracycline degrades, the competitive advantage conferred to bacteria by resistance not only dim... In vitro reconstruction of tetronate RK-682 biosynthesis [作者：SUN YUHUI; HAHN FRANK; DEMYDCHUK YULIYA; CHETTLE JAMES; TOSIN MANUELA; OSADA HIROYUKI; LEADLAY PETER F,期刊：NATURE CHEMICAL BIOLOGY, 页码：99-101 , 文章类型： Article，,卷期：2010年6-2] The protein phosphatase inhibitor RK-682 is one of a number of potentially valuable tetronate polyketide natural products. Understanding how the tetronate ring is formed has been frustrated by the inaccessibility of the ... Chemical reprogramming of Caenorhabditis elegans germ cell fate [作者：MORGAN LINTON T; LEE MYONHEE; KIMBLE JUDITH,期刊：NATURE CHEMICAL BIOLOGY, 页码：102-104 , 文章类型： Article，,卷期：2010年6-2] Small molecules can control cell fate in vivo and may allow directed induction of desired cell types, providing an attractive alternative to transplant-based approaches in regenerative medicine. We have chemically induce... Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont [作者：ZHU YANPING; SUITS MICHAEL D L; THOMPSON ANDREW J; CHAVAN SAMBHAJI; DINEV ZORAN; DUMON CLAIRE; SMITH NICOLA; MOREMEN KELLEY W; XIANG YONG; SIRIWARDENA ALOYSIUS; WILLIAMS SPENCER J; GILBERT HARRY J; DAVIES GIDEON J,期刊：NATURE CHEMICAL BIOLOGY, 页码：125-132 , 文章类型： Article，,卷期：2010年6-2] Colonic bacteria, exemplified by Bacteroides thetaiotaomicron, play a key role in maintaining human health by harnessing large families of glycoside hydrolases (GHs) to exploit dietary polysaccharides and host glycans as... Substrate-dependent proton antiport in neurotransmitter:sodium symporters [作者：ZHAO YONGFANG; QUICK MATTHIAS; SHI LEI; MEHLER ERNEST L; WEINSTEIN HAREL; JAVITCH JONATHAN A,期刊：NATURE CHEMICAL BIOLOGY, 页码：109-116 , 文章类型： Article，,卷期：2010年6-2] Neurotransmitter-sodium symporters (NSS), targets for psychostimulants and therapeutic drugs, have a critical role in-neurotransmission. Whereas eukaryotic NSS show chloride-dependent transport, bacterial NSS feature Cl-... The p110 delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors [作者：BERNDT ALEX; MILLER SIMON; WILLIAMS OLUSEGUN; LE DANIEL D; HOUSEMAN BENJAMIN T; PACOLD JOSEPH I; GORREC FABRICE; HON WAICHING; LIU YI; ROMMEL CHRISTIAN; GAILLARD PASCALE; RUECKLE THOMAS; SCHWARZ MATTHIAS K; SHOKAT KEVAN M; SHAW JEFFREY P; WILLIAMS ROGER L,期刊：NATURE CHEMICAL BIOLOGY, 页码：117-124 , 文章类型： Article，,卷期：2010年6-2] Deregulation of the phosphoinositide-3-OH kinase (PI(3) K) pathway has been implicated in numerous pathologies-including cancer, diabetes, thrombosis, rheumatoid arthritis and asthma. Recently, small-molecule and ATP-com... A causative link between the structure of aberrant protein oligomers and their toxicity [作者：CAMPIONI SILVIA; MANNINI BENEDETTA; ZAMPAGNI MARIAGIOIA; PENSALFINI ANNA; PARRINI CLAUDIA; EVANGELISTI ELISA; RELINI ANNALISA; STEFANI MASSIMO; DOBSON CHRISTOPHER M; CECCHI CRISTINA; CHITI FABRIZIO,期刊：NATURE CHEMICAL BIOLOGY, 页码：140-147 , 文章类型： Article，,卷期：2010年6-2] The aberrant assembly of peptides and proteins into fibrillar aggregates proceeds through oligomeric intermediates that are thought to be the primary pathogenic species in many protein deposition diseases. We describe tw... An in vitro translation, selection and amplification system for peptide nucleic acids [作者：BRUDNO YEVGENY; BIRNBAUM MICHAEL E; KLEINER RALPH E; LIU DAVID R,期刊：NATURE CHEMICAL BIOLOGY, 页码：148-155 , 文章类型： Article，,卷期：2010年6-2] Methods to evolve synthetic, rather than biological, polymers could significantly expand the functional potential of polymers that emerge from in vitro evolution. Requirements for synthetic polymer evolution include (i) ... Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma [作者：CHOI SUNGWOOK; CONNELLY STEPHEN; REIXACH NATALIA; WILSON IAN A; KELLY JEFFERY W,期刊：NATURE CHEMICAL BIOLOGY, 页码：133-139 , 文章类型： Article，,卷期：2010年6-2] A small molecule that could bind selectively to and then react chemoselectively with a non-enzyme protein in a complex biological fluid, such as blood, could have numerous practical applications. Herein, we report a fami... AMPA receptors and synaptic plasticity: a chemist's perspective [作者：FLEMING JAMES J; ENGLAND PAMELA M,期刊：NATURE CHEMICAL BIOLOGY, 页码：89-97 , 文章类型： Review，,卷期：2010年6-2] The ability of the mammalian brain to undergo experience-based adaptations is among its most important and fascinating properties. Such plasticity is reflected in the capacity of neuronal activity to continuously modify ... PI(3) KINASES Revealing the delta lady [作者：WORKMAN PAUL; VAN MONTFORT ROB L M,期刊：NATURE CHEMICAL BIOLOGY, 页码：82-83 , 文章类型： News Item，,卷期：2010年6-2] STEM CELLS Chemically reprogramming cell fates [作者：ELLIS RONALD E,期刊：NATURE CHEMICAL BIOLOGY, 页码：84-85 , 文章类型： News Item，,卷期：2010年6-2] ANTIBIOTICS Inactive but not inert [作者：WRIGHT GERARD D,期刊：NATURE CHEMICAL BIOLOGY, 页码：85-86 , 文章类型： News Item，,卷期：2010年6-2] DIRECTED EVOLUTION Overcoming biology's limitations [作者：APPELLA DANIEL H,期刊：NATURE CHEMICAL BIOLOGY, 页码：87-88 , 文章类型： News Item，,卷期：2010年6-2]