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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Structural and mechanistic basis for a new mode of glycosyltransferase inhibition [作者：PESNOT THOMAS; JORGENSEN RENE; PALCIC MONICA M; WAGNER GERD K,期刊：NATURE CHEMICAL BIOLOGY, 页码：321-323 , 文章类型： Article，,卷期：2010年6-5] Glycosyltransferases are carbohydrate-active enzymes with essential roles in numerous important biological processes. We have developed a new donor analog for galactosyltransferases that locks a representative target enz... Activation of membrane-permeant caged PtdIns(3)P induces endosomal fusion in cells [作者：SUBRAMANIAN DEVARAJ; LAKETA VIBOR; MUELLER RAINER; TISCHER CHRISTIAN; ZARBAKHSH SIRUS; PEPPERKOK RAINER; SCHULTZ CARSTEN,期刊：NATURE CHEMICAL BIOLOGY, 页码：324-326 , 文章类型： Article，,卷期：2010年6-5] Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a phospholipid residing on early endosomes, where it is proposed to be involved in endosomal fusion. We synthesized membrane-permeant derivatives of PtdIns(3)P, including ... A vancomycin photoprobe identifies the histidine kinase VanSsc as a vancomycin receptor [作者：KOTEVA KALINKA; HONG HEEJEON; WANG XIAO DONG; NAZI ISHAC; HUGHES DONALD; NALDRETT MIKE J; BUTTNER MARK J; WRIGHT GERARD D,期刊：NATURE CHEMICAL BIOLOGY, 页码：327-329 , 文章类型： Article，,卷期：2010年6-5] Inducible resistance to the glycopeptide antibiotic vancomycin requires expression of vanH, vanA and vanX, controlled by a two-component regulatory system consisting of a receptor histidine kinase, VanS, and a response r... Acetylation regulates Cyclophilin A catalysis, immunosuppression and HIV isomerization [作者：LAMMERS MICHAEL; NEUMANN HEINZ; CHIN JASON W; JAMES LEO C,期刊：NATURE CHEMICAL BIOLOGY, 页码：331-337 , 文章类型： Article，,卷期：2010年6-5] Cyclophilin A (CypA) is a ubiquitous cis-trans prolyl isomerase with key roles in immunity and viral infection. CypA suppresses T-cell activation through cyclosporine complexation and is required for effective HIV-1 repl... Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc [作者：TEO CHIN FEN; INGALE SAMPAT; WOLFERT MARGREET A; ELSAYED GALAL A; NOET LASZLO G; CHATHAM JOHN C; WELLS LANCE; BOONS GEERTJAN,期刊：NATURE CHEMICAL BIOLOGY, 页码：338-343 , 文章类型： Article，,卷期：2010年6-5] Studies of post-translational modification by beta-N-acetyl-D-glucosamine (O-GlcNAc) are hampered by a lack of efficient tools such as O-GlcNAc-specific antibodies that can be used for detection, isolation and site local... Atomic mutagenesis reveals A2660 of 23S ribosomal RNA as key to EF-G GTPase activation [作者：CLEMENTI NINA; CHIRKOVA ANNA; PUFFER BARBARA; MICURA RONALD; POLACEK NORBERT,期刊：NATURE CHEMICAL BIOLOGY, 页码：344-351 , 文章类型： Article，,卷期：2010年6-5] Following ribosomal peptide bond formation, the reaction products, peptidyl-tRNA and deacylated tRNA, need to be translocated from the A- and P-sites to the P- and E-sites, respectively. This process is facilitated by th... The role of conformational entropy in molecular recognition by calmodulin [作者：MARLOW MICHAEL S; DOGAN JAKOB; FREDERICK KENDRA K; VALENTINE KATHLEEN G; WAND A JOSHUA,期刊：NATURE CHEMICAL BIOLOGY, 页码：352-358 , 文章类型： Article，,卷期：2010年6-5] The physical basis for high-affinity interactions involving proteins is complex and potentially involves a range of energetic contributions. Among these are changes in protein conformational entropy, which cannot yet be ... Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function [作者：KWIATKOWSKI NICHOLAS; JELLUMA NANNETTE; FILIPPAKOPOULOS PANAGIS; SOUNDARARAJAN MEERA; MANAK MICHAEL S; KWON MIJUNG; CHOI HWAN GEUN; SIM TAEBO; DEVERAUX QUINN L; ROTTMANN SABINE; PELLMAN DAVID; SHAH JAGESH V; KOPS GEERT J P L; KNAPP STEFAN; GRAY NATHANAEL S,期刊：NATURE CHEMICAL BIOLOGY, 页码：359-368 , 文章类型： Article，,卷期：2010年6-5] Mps1, a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. As Mps1 function has been implicated in numerous phases of the ... Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP [作者：KOHOUT SUSY C; BELL SARAH C; LIU LIJUN; XU QIANG; MINOR DANIEL L JR; ISACOFF EHUD Y,期刊：NATURE CHEMICAL BIOLOGY, 页码：369-375 , 文章类型： Article，,卷期：2010年6-5] In the voltage-sensing phosphatase Ci-VSP, a voltage-sensing domain (VSD) controls a lipid phosphatase domain (PD). The mechanism by which the domains are allosterically coupled is not well understood. Using an in vivo a... Self-poisoning of Mycobacterium tuberculosis by targeting GlgE in an alpha-glucan pathway [作者：KALSCHEUER RAINER; SYSON KARL; VEERARAGHAVAN USHA; WEINRICK BRIAN; BIERMANN KAROLIN E; LIU ZHEN; SACCHETTINI JAMES C; BESRA GURDYAL; BORNEMANN STEPHEN; JACOBS WILLIAM R JR,期刊：NATURE CHEMICAL BIOLOGY, 页码：376-384 , 文章类型： Article，,卷期：2010年6-5] New chemotherapeutics are urgently required to control the tuberculosis pandemic. We describe a new pathway from trehalose to alpha-glucan in Mycobacterium tuberculosis comprising four enzymatic steps mediated by TreS, P... DATABASES Compound bioactivities go public [作者：BENDER ANDREAS,期刊：NATURE CHEMICAL BIOLOGY, 页码：309-309 , 文章类型： Database Review，,卷期：2010年6-5] THERMODYNAMICS The world is flat [作者：SCHWALBE HARALD; RINNENTHAL JOERG,期刊：NATURE CHEMICAL BIOLOGY, 页码：312-313 , 文章类型： News Item，,卷期：2010年6-5] ANTIBIOTICS Vancomycin sensing [作者：ARTHUR MICHEL,期刊：NATURE CHEMICAL BIOLOGY, 页码：313-315 , 文章类型： News Item，,卷期：2010年6-5] LIPIDS PI couples voltage to catalysis [作者：OKAMURA YASUSHI,期刊：NATURE CHEMICAL BIOLOGY, 页码：315-316 , 文章类型： News Item，,卷期：2010年6-5] METABOLISM Biofuel via biodetoxification [作者：DONG HONGWEI; BAO JIE,期刊：NATURE CHEMICAL BIOLOGY, 页码：316-318 , 文章类型： News Item，,卷期：2010年6-5] DRUG DISCOVERY Engineering drug combinations [作者：DIXON SCOTT J; STOCKWELL BRENT R,期刊：NATURE CHEMICAL BIOLOGY, 页码：318-319 , 文章类型： News Item，,卷期：2010年6-5]