- Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors
[作者:Bottcher-Friebertshauser, E; Freuer, C; Sielaff, F; Schmidt, S; Eickmann, M; Uhlendorff, J; Steinmetzer, T; Klenk, HD; Garten, W,期刊:Journal of virology, 页码:5605-5614 , 文章类型: Article,,卷期:2010年84-11]
- Proteolytic cleavage of the influenza virus surface glycoprotein hemagglutinin (HA) by host cell proteases is crucial for infectivity and virus spread. The proteases HAT (human airway trypsin-like protease) and TMPRSS2 (...
- HIV-1 Lentiviral Vector Immunogenicity Is Mediated by Toll-Like Receptor 3 (TLR3) and TLR7
[作者:Breckpot, K; Escors, D; Arce, F; Lopes, L; Karwacz, K; Van Lint, S; Keyaerts, M; Collins, M,期刊:Journal of virology, 页码:5627-5636 , 文章类型: Article,,卷期:2010年84-11]
- Lentiviral vectors are promising vaccine vector candidates that have been tested extensively in preclinical models of infectious disease and cancer immunotherapy. They are also used in gene therapy clinical trials both f...
- Role of Complex Carbohydrates in Human Immunodeficiency Virus Type 1 Infection and Resistance to Antibody Neutralization
[作者:Binley, JM; Ban, YEA; Crooks, ET; Eggink, D; Osawa, K; Schief, WR; Sanders, RW,期刊:Journal of virology, 页码:5637-5655 , 文章类型: Article,,卷期:2010年84-11]
Complex N-glycans flank the receptor binding sites of the outer domain of HIV-1 gp120, ostensibly forming a protective "fence" against antibodies. Here, we investigated the effects of rebuilding this fence w...
- Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections
[作者:Mordstein, M; Neugebauer, E; Ditt, V; Jessen, B; Rieger, T; Falcone, V; Sorgeloos, F; Ehl, S; Mayer, D; Kochs, G; Schwemmle, M; Gunther, S; Drosten, C; Michiels, T; Staeheli, P,期刊:Journal of virology, 页码:5670-5677 , 文章类型: Article,,卷期:2010年84-11]
- Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet uninfected cells by triggering the synthesis of antiviral factors. The relative contributions of the various IFN subtypes to ...
- Inhibition of Dengue Virus Polymerase by Blocking of the RNA Tunnel
[作者:Niyomrattanakit, P; Chen, YL; Dong, HP; Yin, Z; Qing, M; Glickman, JF; Lin, K; Mueller, D; Voshol, H; Lim, JYH; Nilar, S; Keller, TH; Shi, PY,期刊:Journal of virology, 页码:5678-5686 , 文章类型: Article,,卷期:2010年84-11]
- Dengue virus (DENV) is the most prevalent mosquito-borne viral pathogen in humans. Neither vaccine nor antiviral therapy is currently available for DENV. We report here that N-sulfonylanthranilic acid derivatives are all...
- Studies of the "Chain Reversal Regions" of the Avian Sarcoma/Leukosis Virus (ASLV) and Ebolavirus Fusion Proteins: Analogous Residues Are Important, and a His Residue Unique to EnvA Affects the pH Dependence of ASLV Entry
[作者:Delos, SE; La, B; Gilmartin, A; White, JM,期刊:Journal of virology, 页码:5687-5694 , 文章类型: Article,,卷期:2010年84-11]
- Most class I fusion proteins exist as trimers of dimers composed of a receptor binding and a fusion subunit. In their postfusion forms, the three fusion subunits form trimers of hairpins consisting of a central coiled co...
- High-Resolution X-Ray Structure and Functional Analysis of the Murine Norovirus 1 Capsid Protein Protruding Domain
[作者:Taube, S; Rubin, JR; Katpally, U; Smith, TJ; Kendall, A; Stuckey, JA; Wobus, CE,期刊:Journal of virology, 页码:5695-5705 , 文章类型: Article,,卷期:2010年84-11]
- Murine noroviruses (MNV) are closely related to the human noroviruses (HuNoV), which cause the majority of nonbacterial gastroenteritis. Unlike HuNoV, MNV grow in culture and in a small-animal model that represents a tra...
- Coinfecting Prion Strains Compete for a Limiting Cellular Resource
[作者:Shikiya, RA; Ayers, JI; Schutt, CR; Kincaid, AE; Bartz, JC,期刊:Journal of virology, 页码:5706-5714 , 文章类型: Article,,卷期:2010年84-11]
- Prion strain interference can influence the emergence of a dominant strain from a mixture; however, the mechanisms underlying prion strain interference are poorly understood. In our model of strain interference, inoculat...
- Unseasonal Transmission of H3N2 Influenza A Virus During the Swine-Origin H1N1 Pandemic
[作者:Ghedin, E; Wentworth, DE; Halpin, RA; Lin, XD; Bera, J; DePasse, J; Fitch, A; Griesemer, S; Hine, E; Katzel, DA; Overton, L; Proudfoot, K; Sitz, J; Szczypinski, B; St George, K; Spiro, DJ; Holmes, EC,期刊:Journal of virology, 页码:5715-5718 , 文章类型: Article,,卷期:2010年84-11]
- The initial wave of swine-origin influenza A virus (pandemic H1N1/09) in the United States during the spring and summer of 2009 also resulted in an increased vigilance and sampling of seasonal influenza viruses (H1N1 and...
- Inhibition of Xenotropic Murine Leukemia Virus-Related Virus by APOBEC3 Proteins and Antiviral Drugs
[作者:Paprotka, T; Venkatachari, NJ; Chaipan, C; Burdick, R; Delviks-Frankenberry, KA; Hu, WS; Pathak, VK,期刊:Journal of virology, 页码:5719-5729 , 文章类型: Article,,卷期:2010年84-11]
- Xenotropic murine leukemia virus-related virus (XMRV), a gammaretrovirus, has been isolated from human prostate cancer tissue and from activated CD4(+) T cells and B cells of patients with chronic fatigue syndrome, sugge...
- Antiretroviral Therapy in the Clinic
[作者:Tsibris, AMN; Hirsch, MS,期刊:Journal of virology, 页码:5458-5464 , 文章类型: Review,,卷期:2010年84-11]
- Antiretroviral therapy in the developed world has resulted in substantial reductions in HIV-associated morbidity and mortality, changing an HIV diagnosis from a likely death sentence into a manageable chronic infection (...
- Hepatitis C Virus Hypervariable Region 1 Modulates Receptor Interactions, Conceals the CD81 Binding Site, and Protects Conserved Neutralizing Epitopes
[作者:Bankwitz, D; Steinmann, E; Bitzegeio, J; Ciesek, S; Friesland, M; Herrmann, E; Zeisel, MB; Baumert, TF; Keck, ZY; Foung, SKH; Pecheur, EI; Pietschmann, T,期刊:Journal of virology, 页码:5751-5763 , 文章类型: Article,,卷期:2010年84-11]
- The variability of the hepatitis C virus (HCV), which likely contributes to immune escape, is most pronounced in hypervariable region 1 (HVR1) of viral envelope protein 2. This domain is the target for neutralizing antib...
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