- Spark-Induced Sparks As a Mechanism of Intracellular Calcium Alternans in Cardiac Myocytes
[作者:Rovetti, R; Cui, XH; Garfinkel, A; Weiss, JN; Qu, ZL,期刊:Circulation Research, 页码:1582-1591 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Intracellular calcium (Ca) alternans has been widely studied in cardiac myocytes and tissue, yet the underlying mechanism remains controversial. Objective: In this study, we used computational modeling and sim...
- Cyclic Mechanical Stretch Induces Cardiomyocyte Orientation and Polarization of the Gap Junction Protein Connexin43
[作者:Salameh, A; Wustmann, A; Karl, S; Blanke, K; Apel, D; Rojas-Gomez, D; Franke, H; Mohr, FW; Janousek, J; Dhein, S,期刊:Circulation Research, 页码:1592-1602 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Cyclic mechanical stretch (CMS) is an important physiological and pathological factor in the heart. Objective: We examined whether CMS can affect localization of gap junctions with regard to the cell axis. Met...
- Isoform-Selective Physical Coupling of TRPC3 Channels to IP3 Receptors in Smooth Muscle Cells Regulates Arterial Contractility
[作者:Adebiyi, A; Zhao, GL; Narayanan, D; Thomas-Gatewood, CM; Bannister, JP; Jaggar, JH,期刊:Circulation Research, 页码:1603-1612 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Inositol 1,4,5-trisphosphate (IP3)-induced vasoconstriction can occur independently of intracellular Ca2+ release and via IP3 receptor (IP3R) and canonical transient receptor potential (TRPC) channel activatio...
- Xenografted Human Amniotic Membrane-Derived Mesenchymal Stem Cells Are Immunologically Tolerated and Transdifferentiated Into Cardiomyocytes
[作者:Tsuji, H; Miyoshi, S; Ikegami, Y; Hida, N; Asada, H; Togashi, I; Suzuki, J; Satake, M; Nakamizo, H; Tanaka, M; Mori, T; Segawa, K; Nishiyama, N; Inoue, J; Makino, H; Miyado, K; Ogawa, S; Yoshimura, Y; Umezawa, A,期刊:Circulation Research, 页码:1613-1623 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Amniotic membrane is known to have the ability to transdifferentiate into multiple organs and is expected to stimulate a reduced immunologic reaction. Objective: Determine whether human amniotic membrane-deriv...
- Opposing Effects of Apolipoprotein M on Catabolism of Apolipoprotein B-Containing Lipoproteins and Atherosclerosis
[作者:Christoffersen, C; Pedersen, TX; Gordts, PLSM; Roebroek, AJM; Dahlback, B; Nielsen, LB,期刊:Circulation Research, 页码:1624-1634 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Plasma apolipoprotein (apo) M is mainly associated with high-density lipoprotein (HDL). HDL-bound apoM is antiatherogenic in vitro. However, plasma apoM is not associated with coronary heart disease in humans,...
- Glycogen Synthase Kinase-3 beta Regulates Post-Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo
[作者:Woulfe, KC; Gao, E; Lal, H; Harris, D; Fan, Q; Vagnozzi, R; DeCaul, M; Shang, XY; Patel, S; Woodgett, JR; Force, T; Zhou, JB,期刊:Circulation Research, 页码:1635-1645 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Numerous studies have proposed that glycogen synthase kinase (GSK)-3 beta is a central regulator of the hypertrophic response of cardiomyocytes. However, all of this work has relied on overexpression of GSK-3 ...
- Dendritic Cell Function in Transplantation Arteriosclerosis Is Regulated by Heme Oxygenase 1
[作者:Cheng, C; Noorderloos, M; van Deel, ED; Tempel, D; den Dekker, W; Wagtmans, K; Duncker, DJ; Soares, MP; Laman, JD; Duckers, HJ,期刊:Circulation Research, 页码:1656-1666 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: Heme oxygenase (HO) 1 is an important modulator of physiological function with cytoprotective properties. Although HO1 has previously been associated with an improved survival of the vascular allograft in rat ...
- Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction
[作者:Cheng, K; Li, TS; Malliaras, K; Davis, DR; Zhang, YQ; Marban, E,期刊:Circulation Research, 页码:1570-1570 , 文章类型: Article,,卷期:2010年106-10]
- Rationale: The success of cardiac stem cell therapies is limited by low cell retention, due at least in part to washout via coronary veins. Objective: We sought to counter the efflux of transplanted cells by rendering th...
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