- Developmental Exposures of Male Rats to Soy Isoflavones Impact Leydig Cell Differentiation
[作者:Sherrill, JD; Sparks, M; Dennis, J; Mansour, M; Kemppainen, BW; Bartol, FF; Morrison, EE; Akingbemi, BT,期刊:Biology of Reproduction, 页码:488-501 , 文章类型: ,,卷期:2010年83-3]
Testicular Leydig cells, which are the predominant source of the male sex steroid hormone testosterone, express estrogen receptors (ESRs) and are subject to regulation by estrogen. Following ingestion, the two major i...
- High Levels of DNA Fragmentation in Spermatozoa Are Associated with Inbreeding and Poor Sperm Quality in Endangered Ungulates
[作者:Ruiz-Lopez, MJ; Evenson, DP; Espeso, G; Gomendio, M; Roldan, ERS,期刊:Biology of Reproduction, 页码:332-338 , 文章类型: Article,,卷期:2010年83-3]
- Inbreeding is known to cause deleterious effects upon reproduction and survival, but its effects upon sperm DNA integrity have not been examined. In the present study, we analyzed this relationship among three endangered...
- Expression and Function of Fibroblast Growth Factor 18 in the Ovarian Follicle in Cattle
[作者:Portela, VM; Machado, M; Buratini, J; Zamberlam, G; Amorim, RL; Goncalves, P; Price, CA,期刊:Biology of Reproduction, 页码:339-346 , 文章类型: Article,,卷期:2010年83-3]
- Fibroblast growth factors (FGF) are involved in paracrine signaling between cell types in the ovarian follicle. FGF8, for example, is secreted by oocytes and controls cumulus cell metabolism. The closely related FGF18 is...
- Mice Lacking Two Sperm Serine Proteases, ACR and PRSS21, Are Subfertile, but the Mutant Sperm Are Infertile In Vitro
[作者:Kawano, N; Kang, WJ; Yamashita, M; Koga, Y; Yamazaki, T; Hata, T; Miyado, K; Baba, T,期刊:Biology of Reproduction, 页码:359-369 , 文章类型: Article,,卷期:2010年83-3]
- Although sperm serine protease and proteasome have long been believed to play an important role in the fertilization process, the molecular mechanism is still controversial. In this study, we have produced double-knockou...
- E-Cadherin, as a Negative Regulator of Invasive Behavior of Human Trophoblast Cells, Is Down-Regulated by Cyclosporin A Via Epidermal Growth Factor/Extracellular Signal-Regulated Protein Kinase Signaling Pathway
[作者:Zhao, HB; Wang, C; Li, RX; Tang, CL; Li, MQ; Du, MR; Hou, XF; Li, DJ,期刊:Biology of Reproduction, 页码:370-376 , 文章类型: Article,,卷期:2010年83-3]
- Our previous study has demonstrated cyclosporin A (CsA) promotes the invasiveness of human first-trimester trophoblast cells. In the present study, we further investigated the intracellular signaling pathway responsible ...
- GCM1 Regulation of the Expression of Syncytin 2 and Its Cognate Receptor MFSD2A in Human Placenta
[作者:Liang, CY; Wang, LJ; Chen, CP; Chen, LF; Chen, YH; Chen, HW,期刊:Biology of Reproduction, 页码:387-395 , 文章类型: Article,,卷期:2010年83-3]
- Syncytin 2 is a newly identified placental membrane protein with fusogenic and immunosuppressive activities. Major facilitator superfamily domain containing 2A (MFSD2A) is the cognate receptor for syncytin 2-mediated cel...
- Foxa2 Is Essential for Mouse Endometrial Gland Development and Fertility
[作者:Jeong, JW; Kwak, I; Lee, KY; Kim, TH; Large, MJ; Stewart, CL; Kaestner, KH; Lydon, JP; DeMayo, FJ,期刊:Biology of Reproduction, 页码:396-403 , 文章类型: Article,,卷期:2010年83-3]
- During embryonic development, Foxa2 is required for the formation of the node and notochord, and ablation of this gene results in defects in gastrulation, neural tube patterning, and gut morphogenesis. Foxa2 has been sho...
- Murine Trophoblast Cells Induce NK Cell Interferon-Gamma Production Through KLRK1
[作者:Carayannopoulos, LN; Barks, JL; Yokoyama, WM; Riley, JK,期刊:Biology of Reproduction, 页码:404-414 , 文章类型: Article,,卷期:2010年83-3]
- Murine models suggest that natural killer (NK) cells are important for normal implantation site development, in part, through the production of interferon gamma (IFNG). As KLRK1 (NKG2D) is expressed on human and murine u...
- The Severity of Chorioamnionitis in Pregnant Sheep Is Associated with In Vivo Variation of the Surface-Exposed Multiple-Banded Antigen/Gene of Ureaplasma parvum
[作者:Knox, CL; Dando, SJ; Nitsos, I; Kallapur, SG; Jobe, AH; Payton, D; Moss, TJM; Newnham, JP,期刊:Biology of Reproduction, 页码:415-426 , 文章类型: Article,,卷期:2010年83-3]
- Ureaplasma species are the bacteria most frequently isolated from human amniotic fluid in asymptomatic pregnancies and placental infections. Ureaplasma parvum serovars 3 and 6 are the most prevalent serovars isolated fro...
- Testosterone-Induced Modulation of Nitric Oxide-cGMP Signaling Pathway and Androgenesis in the Rat Leydig Cells
[作者:Andric, SA; Janjic, MM; Stojkov, NJ; Kostic, TS,期刊:Biology of Reproduction, 页码:434-442 , 文章类型: Article,,卷期:2010年83-3]
- Testosterone, acting as a systemic and local factor, is one of the major regulatory molecules that initiate and maintain testicular function. In the present study, different experimental approaches were used to evaluate ...
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