- Dissecting beta-ring assembly pathway of the mammalian 20S proteasome
[作者:Hirano, Y; Kaneko, T; Okamoto, K; Bai, M; Yashiroda, H; Furuyama, K; Kato, K; Tanaka, K; Murata, S,期刊:EMBO journal, 页码:2204-2213 , 文章类型: Article,,卷期:2008年27-16]
- The 20S proteasome is the catalytic core of the 26S proteasome. It comprises four stacked rings of seven subunits each, alpha(1-7)beta(1-7)beta(1-7)alpha(1-7). Recent studies indicated that proteasome-specific chaperones...
- Arabidopsis MAP kinase 4 regulates gene expression through transcription factor release in the nucleus
[作者:Qiu, JL; Fiil, BK; Petersen, K; Nielsen, HB; Botanga, CJ; Thorgrimsen, S; Palma, K; Suarez-Rodriguez, MC; Sandbech-Clausen, S; Lichota, J; Brodersen, P; Grasser, KD; Mattsson, O; Glazebrook, J; Mundy, J; Petersen, M,期刊:EMBO journal, 页码:2214-2221 , 文章类型: Article,,卷期:2008年27-16]
- Plant and animal perception of microbes through pathogen surveillance proteins leads to MAP kinase signalling and the expression of defence genes. However, little is known about how plant MAP kinases regulate specific ge...
- Structure of the Roc-COR domain tandem of C-tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
[作者:Gotthardt, K; Weyand, M; Kortholt, A; Van Haastert, PJM; Wittinghofer, A,期刊:EMBO journal, 页码:2239-2249 , 文章类型: Article,,卷期:2008年27-16]
- Ras of complex proteins (Roc) belongs to the superfamily of Ras-related small G-proteins that always occurs in tandem with the C-terminal of Roc (COR) domain. This Roc-COR tandem is found in the bacterial and eukaryotic ...
- Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase
[作者:Costa, A; van Duinen, G; Medagli, B; Chong, J; Sakakibara, N; Kelman, Z; Nair, SK; Patwardhan, A; Onesti, S,期刊:EMBO journal, 页码:2250-2258 , 文章类型: Article,,卷期:2008年27-16]
- The eukaryotic MCM2-7 complex is recruited at origins of replication during the G1 phase and acts as the main helicase at the replication fork during the S phase of the cell cycle. To characterize the interplay between t...
- Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling (vol 27, pg 1919, 2008)
[作者:Ikenoue, T; Inoki, K; Yang, Q; Zhou, XM; Guan, KL,期刊:EMBO journal, 页码:2270-2270 , 文章类型: Correction,,卷期:2008年27-16]
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- Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
[作者:Joshi, J; Fernandez-Marcos, PJ; Galvez, A; Amanchy, R; Linares, JF; Duran, A; Pathrose, P; Leitges, M; Canamero, M; Collado, M; Salas, C; Serrano, M; Moscat, J; Diaz-Meco, MT,期刊:EMBO journal, 页码:2181-2193 , 文章类型: Article,,卷期:2008年27-16]
- The atypical PKC-interacting protein, Par-4, inhibits cell survival and tumorigenesis in vitro, and its genetic inactivation in mice leads to reduced lifespan, enhanced benign tumour development and low-frequency carcino...
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