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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   Stimulation of Sigma-1 receptor signaling by dehydroepiandrosterone ameliorates pressure overload-induced hypertrophy and dysfunctions in ovariectomized rats [作者：Bhuiyan, MS; Fukunaga, K,期刊：Expert Opinion on Therapeutic Targets, 页码：1253-1265 , 文章类型： Article，,卷期：2009年13-11] Objective: Decreased dehydroepiandrosterone (DHEA) levels are associated with endothelial dysfunction and increased cardiovascular mortality in postmenopausal women. We investigated the role of DHEA, also known as sigma-... Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation [作者：Eltzschig, HK; Rivera-Nieves, J; Colgan, SP,期刊：Expert Opinion on Therapeutic Targets, 页码：1267-1277 , 文章类型： Review，,卷期：2009年13-11] Extracellular adenosine functions as an endogenous distress signal via activation of four distinct adenosine receptors (A1, A2A, A2B and A3). Conditions of limited oxygen availability or acute inflammation lead to elevat... Translation initiation: a critical signalling node in cancer [作者：Robert, F; Pelletier, J,期刊：Expert Opinion on Therapeutic Targets, 页码：1279-1293 , 文章类型： Review，,卷期：2009年13-11] Mammalian target of rapamycin (mTOR) is a master regulator of translation initiation that controls the recruitment of ribosomes to mRNA templates in response to intracellular and extracellular cues. Evidence suggests tha... Pigment epithelium-derived factor (PEDF) as a therapeutic target in cardiovascular disease [作者：Rychli, K; Huber, K; Wojta, J,期刊：Expert Opinion on Therapeutic Targets, 页码：1295-1302 , 文章类型： Review，,卷期：2009年13-11] In this review we discuss the role of pigment epithelium-derived factor (PEDF) as a possible new target molecule to therapeutically influence cardiovascular disease. PEDF is a multifunctional, pleiotropic protein with an... Targeting SGK1 in diabetes [作者：Lang, F; Gorach, A; Vallon, V,期刊：Expert Opinion on Therapeutic Targets, 页码：1303-1311 , 文章类型： Review，,卷期：2009年13-11] Compelling evidence is accumulating indicating a pathophysiological role of the serum-and-glucocorticoid-inducible-kinase-1 (SGK1) in the development and complications of diabetes. SGK1 is ubiquitously expressed with exq... P2X(7)-mediated chemoprevention of epithelial cancers [作者：Gorodeski, GI,期刊：Expert Opinion on Therapeutic Targets, 页码：1313-1332 , 文章类型： Review，,卷期：2009年13-11] Background: Anti-apoptotic mechanisms contribute to the development of cancer. The purinergic ligand-gated ion channel receptor P2X(7) system is an important pro-apoptosis modulator in epithelial cells, and augmentation ... cIAP2 as a therapeutic target in colorectal cancer and other malignancies [作者：Miura, K; Karasawa, H; Sasaki, I,期刊：Expert Opinion on Therapeutic Targets, 页码：1333-1345 , 文章类型： Review，,卷期：2009年13-11] Colorectal cancer is one of the most common malignancies worldwide and 70% of tumors are resectable, but patients with metastatic diseases cannot be cured with current treatment modalities. Inhibition of the apoptotic pa... Targeting the EGF receptor ectodomain in the context of cancer [作者：Huang, L; De Baetselier, P; Beyaert, R,期刊：Expert Opinion on Therapeutic Targets, 页码：1347-1361 , 文章类型： Review，,卷期：2009年13-11] With the discovery of the involvement of the ErbB family of transmembrane growth factor receptors in tumour malignancy, major efforts have been undertaken to develop agents able to specifically target these receptors. Wi... Role of type 3 deiodinase in cancer [作者：Dentice, M; Ambrosio, R; Salvatore, D,期刊：Expert Opinion on Therapeutic Targets, 页码：1363-1373 , 文章类型： Review，,卷期：2009年13-11] Thyroid hormone (TH) influences a wide variety of biological events in vertebrates. Among them, the balance between proliferation and differentiation is crucial in TH action in normal and pathological conditions, includi...