- A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
[作者:Guo, QD; Dong, H; Liu, XN; Wang, CM; Liu, NN; Zhang, JN; Li, B; Cao, WD; Ding, TB; Yang, ZY; Zhang, X,期刊:Expert Opinion on Therapeutic Targets, 页码:733-741 , 文章类型: Article,,卷期:2009年13-7]
- Objective: A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells. This study investigates A20 expression in human glioma tissues and four glioma cell li...
- Atorvastatin affects low density lipoprotein and non-high density lipoprotein cholesterol relations with apolipoprotein B in type 2 diabetes mellitus: modification by triglycerides and cholesteryl ester transfer protein
[作者:Kappelle, PJWH; Zwang, L; Huisman, MV; Banga, JD; Sluiter, WJ; Dallinga-Thie, GM; Dullaart, RPF,期刊:Expert Opinion on Therapeutic Targets, 页码:743-751 , 文章类型: Article,,卷期:2009年13-7]
- Objectives: Non-HDL-cholesterol (non-HDL-C) and apolipoprotein (apo) B are proposed as treatment targets. The extent to which statin therapy affects relationships of LDL-C and non-HDL-C with apoB was examined in type 2 d...
- EMP3 as a candidate tumor suppressor gene for solid tumors
[作者:Fumoto, S; Tanimoto, K; Hiyama, E; Noguchi, T; Nishiyama, M; Hiyama, K,期刊:Expert Opinion on Therapeutic Targets, 页码:811-822 , 文章类型: Review,,卷期:2009年13-7]
- Background: Epithelial membrane protein 3 (EMP3), was recently reported to be a tumor suppressor gene for several solid tumors, and is drawing attention as a novel prognostic marker, since its expression level or hyperme...
- Dickkopf-1: a suitable target for the management of myeloma bone disease
[作者:Gavriatopoulou, M; Dimopoulos, MA; Christoulas, D; Migkou, M; Iakovaki, M; Gkotzamanidou, M; Terpos, E,期刊:Expert Opinion on Therapeutic Targets, 页码:839-848 , 文章类型: Review,,卷期:2009年13-7]
- Bone disease remains a major problem in the management of patients with multiple myeloma (MM) and is characterized by the presence of lytic lesions due to increased osteoclastic activity and reduced osteoblast function. ...
- Prostaglandin E-2 synthase inhibition as a therapeutic target
[作者:Iyer, JP; Srivastava, PK; Dev, R; Dastidar, SG; Ray, A,期刊:Expert Opinion on Therapeutic Targets, 页码:849-865 , 文章类型: Review,,卷期:2009年13-7]
- Background: Most NSAIDs function by inhibiting biosynthesis of PGE(2) by inhibition of COX-1 and/or COX-2. Since COX-1 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycl...
- Effects of pharmaceuticals and other active chemicals at biological targets: mechanisms, interactions, and integration into PB-PK/PD models
[作者:Kapitulnik, J; Pelkonen, O; Gundert-Remy, U; Dahl, SG; Boobis, AR,期刊:Expert Opinion on Therapeutic Targets, 页码:867-887 , 文章类型: Review,,卷期:2009年13-7]
- Biologically active molecules, that is pharmaceuticals and other chemical substances, exert their therapeutic and/or toxic effects by complex interactions with their biological targets/active sites. This review discusses...
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