- Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3 '-Carbamoyl-3-yl Ester (URB597) Reverses Abuse-Related Behavioral and Neurochemical Effects of Nicotine in Rats
[作者:Scherma, M; Panlilio, LV; Fadda, P; Fattore, L; Gamaleddin, I; Le Foll, B; Justinova, Z; Mikics, E; Haller, J; Medalie, J; Stroik, J; Barnes, C; Yasar, S; Tanda, G; Piomelli, D; Fratta, W; Goldberg, SR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:482-490 , 文章类型: Article,,卷期:2008年327-2]
Emerging evidence suggests that the rewarding, abuse-related effects of nicotine are modulated by the endocannabinoid system of the brain. For example, pharmacological blockade or genetic deletion of cannabinoid CB1 r...
- sigma-1 Receptor Modulation of Acid-Sensing Ion Channel a (ASIC1a) and ASIC1a-Induced Ca2+ Influx in Rat Cortical Neurons
[作者:Herrera, Y; Katnik, C; Rodriguez, JD; Hall, AA; Willing, A; Pennypacker, KR; Cuevas, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:491-502 , 文章类型: Article,,卷期:2008年327-2]
Acid-sensing ion channels (ASICs) are proton-gated cation channels found in peripheral and central nervous system neurons. The ASIC1a subtype, which has high Ca2+ permeability, is activated by ischemia-induced acidosi...
- alpha Conotoxin Arenatus IB[V11I,V16D] Is a Potent and Selective Antagonist at Rat and Human Native alpha 7 Nicotinic Acetylcholine Receptors
[作者:Innocent, N; Livingstone, PD; Hone, A; Kimura, A; Young, T; Whiteaker, P; McIntosh, JM; Wonnacott, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:529-537 , 文章类型: Article,,卷期:2008年327-2]
A recently developed alpha-conotoxin, alpha-conotoxin Arenatus IB-[V11L,V16D] (alpha-CtxArIB[V11L,V16D]), is a potent and selective competitive antagonist at rat recombinant alpha 7 nicotinic acetylcholine receptors (...
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