- Structure and Function of a "Yellow" Protein from Saliva of the Sand Fly Lutzomyia longipalpis That Confers Protective Immunity against Leishmania major Infection
[作者:Xu, XQ; Oliveira, F; Chang, BW; Collin, N; Gomes, R; Teixeira, C; Reynoso, D; Pham, VM; Elnaiem, DE; Kamhawi, S; Ribeiro, JMC; Valenzuela, JG; Andersen, JF,期刊:Journal of Biological Chemistry, 页码:32383-32393 , 文章类型: Article,,卷期:2011年286-37]
- LJM11, an abundant salivary protein from the sand fly Lutzomyia longipalpis, belongs to the insect "yellow" family of proteins. In this study, we immunized mice with 17 plasmids encoding L. longiplapis salivary proteins ...
- Na/K-ATPase Mimetic pNaKtide Peptide Inhibits the Growth of Human Cancer Cells
[作者:Li, ZC; Zhang, ZB; Xie, JX; Li, X; Tian, J; Cai, T; Cui, HJ; Ding, HF; Shapiro, JI; Xie, ZJ,期刊:Journal of Biological Chemistry, 页码:32394-32403 , 文章类型: Article,,卷期:2011年286-37]
- Cells contain a large pool of nonpumping Na/K-ATPase that participates in signal transduction. Here, we show that the expression of alpha 1 Na/K-ATPase is significantly reduced in human prostate carcinoma as well as in s...
- Src Homology Domain 2-containing Protein-tyrosine Phosphatase-1 (SHP-1) Binds and Dephosphorylates G alpha-interacting, Vesicle-associated Protein (GIV)/Girdin and Attenuates the GIV-Phosphatidylinositol 3-Kinase (PI3K)-Akt Signaling Pathway
[作者:Mittal, Y; Pavlova, Y; Garcia-Marcos, M; Ghosh, P,期刊:Journal of Biological Chemistry, 页码:32404-32415 , 文章类型: Article,,卷期:2011年286-37]
- GIV (G alpha-interacting vesicle-associated protein, also known as Girdin) is a bona fide enhancer of PI3K-Akt signals during a diverse set of biological processes, e. g. wound healing, macrophage chemotaxis, tumor angio...
- cAMP-response Element (CRE)-mediated Transcription by Activating Transcription Factor-4 (ATF4) Is Essential for Circadian Expression of the Period2 Gene
[作者:Koyanagi, S; Hamdan, AM; Horiguchi, M; Kusunose, N; Okamoto, A; Matsunaga, N; Ohdo, S,期刊:Journal of Biological Chemistry, 页码:32416-32423 , 文章类型: Article,,卷期:2011年286-37]
- Activating transcription factor (ATF)/cAMP-response element (CRE)-binding (CREB) proteins induce the CRE-mediated gene transcription depending on the cAMP stimulation. cAMP-dependent signaling oscillates in a circadian m...
- Mitochondrial Calcium Uptake Regulates Rapid Calcium Transients in Skeletal Muscle during Excitation-Contraction (E-C) Coupling
[作者:Yi, JX; Ma, CL; Li, Y; Weisleder, N; Rios, E; Ma, JJ; Zhou, JS,期刊:Journal of Biological Chemistry, 页码:32436-32443 , 文章类型: Article,,卷期:2011年286-37]
- Defective coupling between sarcoplasmic reticulum and mitochondria during control of intracellular Ca(2+) signaling has been implicated in the progression of neuromuscular diseases. Our previous study showed that skeleta...
- Cigarette Smoke Induces Akt Protein Degradation by the Ubiquitin-Proteasome System
[作者:Kim, SY; Lee, JH; Huh, JW; Ro, JY; Oh, YM; Lee, SD; An, S; Lee, YS,期刊:Journal of Biological Chemistry, 页码:31932-31943 , 文章类型: Article,,卷期:2011年286-37]
- Emphysema is one of the characteristic features of chronic obstructive pulmonary disease, which is caused mainly by cigarette smoking. Recent data have suggested that apoptosis and cell cycle arrest may contribute to the...
- Atomic Force Microscopy Reveals the Architecture of the Epithelial Sodium Channel (ENaC)
[作者:Stewart, AP; Haerteis, S; Diakov, A; Korbmacher, C; Edwardson, JM,期刊:Journal of Biological Chemistry, 页码:31944-31952 , 文章类型: Article,,卷期:2011年286-37]
- The epithelial sodium channel (ENaC) is a member of the ENaC/degenerin superfamily. ENaC is a heteromultimer containing three homologous subunits (alpha, beta, and gamma); however, the subunit stoichiometry is still cont...
- Identification of an Evolutionarily Conserved Family of Inorganic Polyphosphate Endopolyphosphatases
[作者:Lonetti, A; Szijgyarto, Z; Bosch, D; Loss, O; Azevedo, C; Saiardi, A,期刊:Journal of Biological Chemistry, 页码:31966-31974 , 文章类型: Article,,卷期:2011年286-37]
- Inorganic polyphosphate (poly-P) consists of just a chain of phosphate groups linked by high energy bonds. It is found in every organism and is implicated in a wide variety of cellular processes (e.g. phosphate storage, ...
- Apoptosis Induced by Persistent Single-strand Breaks in Mitochondrial Genome CRITICAL ROLE OF EXOG (5 '-EXO/ENDONUCLEASE) IN THEIR REPAIR
[作者:Tann, AW; Boldogh, I; Meiss, G; Qian, W; Van Houten, B; Mitra, S; Szczesny, B,期刊:Journal of Biological Chemistry, 页码:31975-31983 , 文章类型: Article,,卷期:2011年286-37]
- Reactive oxygen species (ROS), continuously generated as by-products of respiration, inflict more damage on the mitochondrial (mt) than on the nuclear genome because of the nonchromatinized nature and proximity to the RO...
- Hepatitis C Virus (HCV) Envelope Glycoproteins E1 and E2 Contain Reduced Cysteine Residues Essential for Virus Entry
[作者:Fraser, J; Boo, I; Poumbourios, P; Drummer, HE,期刊:Journal of Biological Chemistry, 页码:31984-31992 , 文章类型: Article,,卷期:2011年286-37]
- The HCV envelope glycoproteins E1 and E2 contain eight and 18 highly conserved cysteine residues, respectively. Here, we examined the oxidation state of E1E2 heterodimers incorporated into retroviral pseudotyped particle...
- The T Cell Receptor Triggering Apparatus Is Composed of Monovalent or Monomeric Proteins
[作者:James, JR; McColl, J; Oliveira, MI; Dunne, PD; Huang, E; Jansson, A; Nilsson, P; Sleep, DL; Goncalves, CM; Morgan, SH; Felce, JH; Mahen, R; Fernandes, RA; Carmo, AM; Klenerman, D; Davis, SJ,期刊:Journal of Biological Chemistry, 页码:31993-32001 , 文章类型: Article,,卷期:2011年286-37]
- Understanding the component stoichiometry of the T cell antigen receptor (TCR) triggering apparatus is essential for building realistic models of signal initiation. Recent studies suggesting that the TCR and other signal...
- Taurine Biosynthesis by Neurons and Astrocytes
[作者:Vitvitsky, V; Garg, SK; Banerjee, R,期刊:Journal of Biological Chemistry, 页码:32002-32010 , 文章类型: Article,,卷期:2011年286-37]
- The physiological roles of taurine, a product of cysteine degradation and one of the most abundant amino acids in the body, remain elusive. Taurine deficiency leads to heart dysfunction, brain development abnormalities, ...
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