- A role for candidate tumor-suppressor gene TCEAL7 in the regulation of c-Myc activity, cyclin D1 levels and cellular transformation
[作者:Chien, J; Narita, K; Rattan, R; Giri, S; Shridhar, R; Staub, J; Beleford, D; Lai, J; Roberts, LR; Molina, J; Kaufmann, SH; Prendergast, GC; Shridhar, V,期刊:Oncogene, 页码:7223-7234 , 文章类型: Article,,卷期:2008年27-58]
- The pathophysiological mechanisms that drive the development and progression of epithelial ovarian cancer remain obscure. Recently, we identified TCEAL7 as a transcriptional regulatory protein often downregulated in epit...
- Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling
[作者:Guo, X; Waddell, DS; Wang, W; Wang, Z; Liberati, NT; Yong, S; Liu, X; Wang, XF,期刊:Oncogene, 页码:7235-7247 , 文章类型: Article,,卷期:2008年27-58]
- Transforming growth factor-beta (TGF-beta) elicits a variety of cellular activities primarily through a signaling cascade mediated by two key transcription factors, Smad2 and Smad3. Numerous regulatory mechanisms exist t...
- Loss of Hus1 sensitizes cells to etoposide-induced apoptosis by regulating BH3-only proteins
[作者:Meyerkord, CL; Takahashi, Y; Araya, R; Takada, N; Weiss, RS; Wang, HG,期刊:Oncogene, 页码:7248-7259 , 文章类型: Article,,卷期:2008年27-58]
- The Rad9-Rad1-Hus1 (9-1-1) cell cycle checkpoint complex plays a key role in the DNA damage response. Cells with a defective 9-1-1 complex have been shown to be sensitive to apoptosis induced by certain types of genotoxi...
- Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor
[作者:Wykosky, J; Palma, E; Gibo, DM; Ringler, S; Turner, CP; Debinski, W,期刊:Oncogene, 页码:7260-7273 , 文章类型: Article,,卷期:2008年27-58]
- The ephrinA1 ligand exerts antioncogenic effects in tumor cells through activation and downregulation of the EphA2 receptor and has been described as a membrane-anchored protein requiring clustering for function. However...
- Repression of E-cadherin by the polycomb group protein EZH2 in cancer
[作者:Cao, Q; Yu, J; Dhanasekaran, SM; Kim, JH; Mani, RS; Tomlins, SA; Mehra, R; Laxman, B; Cao, X; Yu, J; Kleer, CG; Varambally, S; Chinnaiyan, AM,期刊:Oncogene, 页码:7274-7284 , 文章类型: Article,,卷期:2008年27-58]
- Enhancer of zeste homolog 2 (EZH2) is a critical component of the polycomb-repressive complex 2 (PRC2), which is involved in gene silencing and histone H3 lysine 27 methylation. EZH2 has a master regulatory function in c...
- Implication of human N-alpha-acetyltransferase 5 in cellular proliferation and carcinogenesis
[作者:Ametzazurra, A; Larrea, E; Civeira, MP; Prieto, J; Aldabe, R,期刊:Oncogene, 页码:7296-7306 , 文章类型: Article,,卷期:2008年27-58]
- The N-alpha-acetyltransferase NatB, composed in Saccharomyces cerevisiae by the Nat3p and Mdm20p subunits, is an important factor for yeast growth and resistance to several stress agents. However, the expression and func...
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