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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共48条记录   Phagocytic Clearance in Neurodegeneration [作者：Sokolowski, JD; Mandell, JW,期刊：American Journal of Pathology, 页码：1416-1428 , 文章类型： Review，,卷期：2011年178-4] The cellular and molecular mechanisms of phagocytic clearance of apoptotic cells and debris have been intensely studied in invertebrate model organisms and in the mammalian immune system. This evolutionarily conserved pr... Hepatic Lipase, High Density Lipoproteins, and Hypertriglyceridemia [作者：Chatterjee, C; Sparks, DL,期刊：American Journal of Pathology, 页码：1429-1433 , 文章类型： Review，,卷期：2011年178-4] Hepatic lipase (HL) is a lipolytic enzyme that contributes to the regulation of plasma triglyceride (TG) levels. Elevated TG levels may increase the risk of developing coronary heart disease, and studies suggest that mut... Alteration in the Gene Encoding Protein Tyrosine Phosphatase Nonreceptor Type 6 (PTPN6/SHP1) May Contribute to Neutrophilic Dermatoses [作者：Nesterovitch, AB; Gyorfy, Z; Hoffman, MD; Moore, EC; Elbuluk, N; Tryniszewska, B; Rauch, TA; Simon, M; Kang, S; Fisher, GJ; Mikecz, K; Tharp, MD; Glant, TT,期刊：American Journal of Pathology, 页码：1434-1441 , 文章类型： Article，,卷期：2011年178-4] We have found a B2 repeat insertion in the gene encoding protein tyrosine phosphatase nonreceptor type 6 (PTPN6) in a mouse that developed a skin disorder with clinical and histopathological features resembling those see... Somatic Mutations of PPP2R1A in Ovarian and Uterine Carcinomas [作者：Shih, IM; Panuganti, PK; Kuo, KT; Mao, TL; Kuhn, E; Jones, S; Velculescu, VE; Kurman, RJ; Wang, TL,期刊：American Journal of Pathology, 页码：1442-1447 , 文章类型： Article，,卷期：2011年178-4] Exome sequencing of ovarian clear-cell carcinoma has identified somatic mutations in PPP2R1A, a subunit of protein phosphatase 2A. The present study was performed to determine the frequency of PPP2R1A mutations in exon 5... Helicobacter pylori Induction of Eosinophil Migration Is Mediated by the cag Pathogenicity Island via Microbial-Epithelial Interactions [作者：Nagy, TA; Allen, SS; Wroblewski, LE; Flaherty, DK; Slaughter, JC; Perez-Perez, G; Israel, DA; Peek, RM,期刊：American Journal of Pathology, 页码：1448-1452 , 文章类型： Article，,卷期：2011年178-4] The host immune response directed against Helicobacter pylori is ineffective in eliminating the organism and strains harboring the cag pathogenicity island augment disease risk. Because eosinophils are a prominent compon... Pulmonary Mycobacterial Granuloma Increased IL-10 Production Contributes to Establishing a Symbiotic Host-Microbe Microenvironment [作者：Shaler, CR; Kugathasan, K; McCormick, S; Damjanovic, D; Horvath, C; Small, CL; Jeyanathan, M; Chen, X; Yang, PC; Xing, Z,期刊：American Journal of Pathology, 页码：1622-1634 , 文章类型： Article，,卷期：2011年178-4] The granuloma, a hallmark of host defense against pulmonary mycobacterial infection, has long been believed to be an active type 1 immune environment. However, the mechanisms regarding why granuloma fails to eliminate my... Early Acceptance of Renal Allografts in Mice Is Dependent on Foxp3(+) Cells [作者：Miyajima, M; Chase, CM; Alessandrini, A; Farkash, EA; Della Pelle, P; Benichou, G; Graham, JA; Madsen, JC; Russell, PS; Colvin, RB,期刊：American Journal of Pathology, 页码：1635-1645 , 文章类型： Article，,卷期：2011年178-4] Mouse renal allografts have a remarkable ability to promote acceptance across full major histocompatibility complex incompatibilities in certain strain combinations without immunosuppression. The mechanism is unknown but... Increased CDK5 Expression in HIV Encephalitis Contributes to Neurodegeneration via Tau Phosphorylation and Is Reversed with Roscovitine [作者：Patrick, C; Crews, L; Desplats, P; Dumaop, W; Rockenstein, E; Achim, CL; Everall, IP; Masliah, E,期刊：American Journal of Pathology, 页码：1646-1661 , 文章类型： Article，,卷期：2011年178-4] Recent treatments with highly active antiretroviral therapy (HAART) regimens have been shown to improve general clinical status in patients with human immunodeficiency virus (HIV) infection; however, the prevalence of co... Association of T-Zone Reticular Networks and Conduits with Ectopic Lymphoid Tissues in Mice and Humans [作者：Link, A; Hardie, DL; Favre, S; Britschgi, MR; Adams, DH; Sixt, M; Cyster, JG; Buckley, CD; Luther, SA,期刊：American Journal of Pathology, 页码：1662-1675 , 文章类型： Article，,卷期：2011年178-4] Ectopic or tertiary lymphoid tissues (TLTs) are often induced at sites of chronic inflammation. They typically contain various hematopoietic cell types, high endothelial venules, and follicular dendritic cells; and are o... Expression of Prostaglandin E Synthases in Periodontitis Immunolocalization and Cellular Regulation [作者：Bage, T; Kats, A; Lopez, BS; Morgan, G; Nilsson, G; Burt, I; Korotkova, M; Corbett, L; Knox, AJ; Pino, L; Jakobsson, PJ; Modeer, T; Yucel-Lindberg, T,期刊：American Journal of Pathology, 页码：1676-1688 , 文章类型： Article，,卷期：2011年178-4] The inflammatory mediator prostaglandin E(2) (PGE(2)) is implicated in the pathogenesis of chronic inflammatory diseases including periodontitis; it is synthesized by cyclooxygenases (COX) and the prostaglandin E synthas... Plague in Guinea Pigs and Its Prevention by Subunit Vaccines [作者：Quenee, LE; Ciletti, N; Berube, B; Krausz, T; Elli, D; Hermanas, T; Schneewind, O,期刊：American Journal of Pathology, 页码：1689-1700 , 文章类型： Article，,卷期：2011年178-4] Human pneumonic plague is a devastating and transmissible disease for which a Food and Drug Administration approved vaccine is not available. Suitable animal models may be adopted as a surrogate for human plague to fulfi... Spontaneous Insertion of a B2 Element in the Ptpn6 Gene Drives a Systemic Autoinflammatory Disease in Mice Resembling Neutrophilic Dermatosis in Humans [作者：Nesterovitch, AB; Szanto, S; Gonda, A; Bardos, T; Kis-Toth, K; Adarichev, VA; Olasz, K; Ghassemi-Najad, S; Hoffman, MD; Tharp, MD; Mikecz, K; Glant, TT,期刊：American Journal of Pathology, 页码：1701-1714 , 文章类型： Article，,卷期：2011年178-4] We found a spontaneous autosomal mutation in a mouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring. These animals had increased neutrophil numbers, associated with normal ... Obesity and Hepatosteatosis in Mice with Enhanced Oxidative DNA Damage Processing in Mitochondria [作者：Zhang, HH; Xie, CH; Spencer, HJ; Zuo, CL; Higuchi, M; Ranganathan, G; Kern, PA; Chou, MW; Huang, Q; Szczesny, B; Mitra, S; Watson, AJ; Margison, GP; Fan, CY,期刊：American Journal of Pathology, 页码：1715-1727 , 文章类型： Article，,卷期：2011年178-4] Mitochondria play critical roles in oxidative phosphorylation and energy metabolism. Increasing evidence supports that mitochondrial DNA (mtDNA) damage and dysfunction play vital roles in the development of many mitochon... Transgenic Expression of Laminin alpha 1 Chain Does Not Prevent Muscle Disease in the mdx Mouse Model for Duchenne Muscular Dystrophy [作者：Gawlik, KI; Oliveira, BM; Durbeej, M,期刊：American Journal of Pathology, 页码：1728-1737 , 文章类型： Article，,卷期：2011年178-4] Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder, and one of the most frequently encountered, but one for which there is as yet no treatment. Laminin-111 protein therapy was recently shown to be a pro... PGC-1 alpha Promotes Nitric Oxide Antioxidant Defenses and Inhibits FOXO Signaling Against Cardiac Cachexia in Mice [作者：Geng, TY; Li, P; Yin, XH; Yan, Z,期刊：American Journal of Pathology, 页码：1738-1748 , 文章类型： Article，,卷期：2011年178-4] Chronic heart failure often results in catabolic muscle wasting, exercise intolerance, and death. Oxidative muscles, which have greater expression of the metabolic master gene peroxisome proliferator activated receptor-g... Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage [作者：Chang, CF; Chen, SF; Lee, TS; Lee, HF; Chen, SF; Shyue, SK,期刊：American Journal of Pathology, 页码：1749-1761 , 文章类型： Article，,卷期：2011年178-4] Intracerebral hemorrhage (ICH) is a subtype of stroke with high rates of morbidity and mortality. Caveolin-1 (Cav-1) is the main structural protein of caveolae and is involved in regulating signal transduction and choles...