- Inhibiting Angiotensin-Converting Enzyme Promotes Renal Repair by Limiting Progenitor Cell Proliferation and Restoring the Glomerular Architecture
[作者:Benigni, A; Morigi, M; Rizzo, P; Gagliardini, E; Rota, C; Abbate, M; Ghezzi, S; Remuzzi, A; Remuzzi, G,期刊:American Journal of Pathology, 页码:628-638 , 文章类型: Article,,卷期:2011年179-2]
- We previously reported that angiotensin-converting enzyme inhibitor (ACEi) renoprotection in Munich Wistar Fromter (MWF) rats, which develop progressive glomerular injury, was associated with podocyte repopulation and pr...
- Deficiency of a Transcriptional Regulator, Inhibitor of Differentiation 3, Induces Glomerulonephritis in Apolipoprotein E-Deficient Mice A Model Linking Hyperlipidemia and Renal Disease
[作者:Bagavant, H; Scindia, Y; Nackiewicz, D; Nandula, SR; Doran, A; Cutchins, A; Oldham, S; Deshmukh, U; McNamara, C,期刊:American Journal of Pathology, 页码:651-660 , 文章类型: Article,,卷期:2011年179-2]
- The clinical association between hyperlipidemia and renal disease is well established, yet hyperlipidemia as a cause for renal disease is rare. Apolipoprotein E-deficient (ApoE(-/-)) mice develop hyperlipidemia and are a...
- miR-21 and miR-214 Are Consistently Modulated during Renal Injury in Rodent Models
[作者:Denby, L; Ramdas, V; McBride, MW; Wang, J; Robinson, H; McClure, J; Crawford, W; Lu, RF; Hillyard, DZ; Khanin, R; Agami, R; Dominiczak, AF; Sharpe, CC; Baker, AH,期刊:American Journal of Pathology, 页码:661-672 , 文章类型: Article,,卷期:2011年179-2]
- Transforming growth factor (TGF)-beta is one of the main fibrogenic cytokines that drives the pathophysiology of progressive renal scarring. MicroRNAs (miRNAs) are endogenous non-coding RNAs that post-transcriptionally r...
- Altered Mitochondrial Function in Type 2 Granular Corneal Dystrophy
[作者:Kim, TI; Kim, H; Lee, DJ; Choi, SI; Kang, SW; Kim, EK,期刊:American Journal of Pathology, 页码:684-692 , 文章类型: Article,,卷期:2011年179-2]
- Type 2 granular corneal dystrophy (GCD2) is caused by point mutation R124H in the transforming growth factor-beta-induced gene (TGFBI) and is characterized by age-dependent progression of corneal deposits. Mitochondrial ...
- Zinc Deprivation Mediates Alcohol-Induced Hepatocyte IL-8 Analog Expression in Rodents via an Epigenetic Mechanism
[作者:Zhao, YT; Zhong, W; Sun, XH; Song, ZY; Clemens, DL; Kang, YJ; McClain, CJ; Zhou, ZX,期刊:American Journal of Pathology, 页码:693-702 , 文章类型: Article,,卷期:2011年179-2]
- Neutrophil infiltration caused by IL-8 production is a central mechanism in alcohol-induced hepatitis. This study was performed to examine if an epigenetic mechanism is involved in alcohol-induced IL-8 production. Mice w...
- Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1-Deficient Mice
[作者:Huang, JS; Viswakarma, N; Yu, ST; Jia, YZ; Bai, L; Vluggens, A; Cherkaoui-Malki, M; Khan, M; Singh, I; Yang, GS; Rao, MS; Borensztajn, J; Reddy, JK,期刊:American Journal of Pathology, 页码:703-713 , 文章类型: Article,,卷期:2011年179-2]
- Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(-/-)) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferatio...
- Hepatoprotective versus Oncogenic Functions of STAT3 in Liver Tumorigenesis
[作者:Wang, H; Lafdil, F; Wang, L; Park, O; Yin, S; Niu, JY; Miller, AM; Sun, ZL; Gao, B,期刊:American Journal of Pathology, 页码:714-724 , 文章类型: Article,,卷期:2011年179-2]
- Aberrantly hyperactivated STAT3 has been found in human liver cancers as an oncogene; however, STAT3 has also been shown to exert hepatoprotective effects during liver injury. The balancing act that STAT3 plays between h...
- Inhibition of Fas Ligand in NOD Mice Unmasks a Protective Role for IL-10 against Insulitis Development
[作者:Xiao, ZX; Mohamood, AS; Uddin, S; Gutfreund, R; Nakata, C; Marshall, A; Kimura, H; Caturegli, P; Womer, KL; Huang, YF; Jie, CF; Chakravarti, S; Schneck, JP; Yagita, H; Hamad, ARA,期刊:American Journal of Pathology, 页码:725-732 , 文章类型: Article,,卷期:2011年179-2]
- Type 1 diabetes mellitus (T1D) is an autoimmune disease caused by the destruction of pancreatic insulin-producing beta cells by autoreactive T cells early in life. Despite daily insulin injections, patients typically dev...
- Eosinophils Contribute to IL-4 Production and Shape the T-Helper Cytokine Profile and Inflammatory Response in Pulmonary Cryptococcosis
[作者:Piehler, D; Stenzel, W; Grahnert, A; Held, J; Richter, L; Kohler, G; Richter, T; Eschke, M; Alber, G; Muller, U,期刊:American Journal of Pathology, 页码:733-744 , 文章类型: Article,,卷期:2011年179-2]
- Susceptibility to infection with Ctyptococcus neoformans is tightly determined by production of IL-4. In this study, we investigated the time course of IL-4 production and its innate cellular source in mice infected intr...
- An Extensive Tumor Array Analysis Supports Tumor Suppressive Role for Nucleophosmin in Breast Cancer
[作者:Karhemo, PR; Rivinoja, A; Lundin, J; Hyvonen, M; Chernenko, A; Lammi, J; Sihto, H; Lundin, M; Heikkila, P; Joensuu, H; Bono, P; Laakkonen, P,期刊:American Journal of Pathology, 页码:1004-1014 , 文章类型: Article,,卷期:2011年179-2]
- Nucleophosmin (NPM) is a multifunctional protein involved in a complex network of interactions. The role of NPM in oncogenesis is controversial. The NPM gene (NPM1) is mutated or rearranged in a number of hematological d...
- Keratin 19 Epithelial Patterns in Cirrhotic Stroma Parallel Hepatocarcinogenesis
[作者:Lennerz, JKM; Chapman, WC; Brunt, EM,期刊:American Journal of Pathology, 页码:1015-1029 , 文章类型: Article,,卷期:2011年179-2]
- Cirrhotic septa harbor vessels and inflammatory, fibrogenic, and ductular epithelial cells, collectively referred to as the ductular reaction (DR). Lack of the DR in the stromal compartment around hepatocellular carcinom...
- In Vivo and in Vitro Evidence That PPAR gamma Ligands Are Antagonists of Leptin Signaling in Breast Cancer
[作者:Catalano, S; Mauro, L; Bonofiglio, D; Pellegrino, M; Qi, HY; Rizza, P; Vizza, D; Bossi, G; Ando, S,期刊:American Journal of Pathology, 页码:1030-1040 , 文章类型: Article,,卷期:2011年179-2]
- Obesity is a major risk factor for the development and progression of breast cancer. Leptin, a cytokine mainly produced by adipocytes, plays a crucial role in mammary carcinogenesis and is elevated in hyperinsulinemia an...
- Podoplanin Is Regulated by AP-1 and Promotes Platelet Aggregation and Cell Migration in Osteosarcoma
[作者:Kunita, A; Kashima, TG; Ohazama, A; Grigoriadis, AE; Fukayama, M,期刊:American Journal of Pathology, 页码:1041-1049 , 文章类型: Article,,卷期:2011年179-2]
- Podoplanin is a type-I transmembrane sialomucin-like protein, which is expressed in a wide range of cell types and is involved in platelet aggregation and tumor metastasis. Here, we investigated the function, regulation,...
- Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice
[作者:Le, TTT; Morita, T; Yoshida, K; Wakasa, K; Lizuka, M; Ogawa, T; Mori, M; Sekiya, Y; Momen, S; Motoyama, H; Ikeda, K; Yoshizato, K; Kawada, N,期刊:American Journal of Pathology, 页码:1050-1060 , 文章类型: Article,,卷期:2011年179-2]
- Cytoglobin (Cygb) is a recently discovered vertebrate globin with molecular characteristics that are similar to myoglobin. To study the biological function of Cygb in vivo, we generated Cygb knockout mice and investigate...
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