- Transferred Antigen-Specific T(H)17 but not T(H)1 Cells Induce Crescentic Glomerulonephritis in Mice
[作者：Tulone, C; Giorgini, A; Freeley, S; Coughlan, A; Robson, MG,期刊：American Journal of Pathology, 页码：2683-2690 , 文章类型： Article，,卷期：2011年179-6]
- To explore the role of antigen-specific CD4(+) T cells in glomerulonephritis, we administered ovalbumin 323-339 peptide conjugated to glomerular-binding polyclonal antibody and induced disease in RAG1(-/-) mice with CD4(...
- Apelin Attenuates UVB-Induced Edema and Inflammation by Promoting Vessel Function
[作者：Sawane, M; Kidoya, H; Muramatsu, F; Takakura, N; Kajiya, K,期刊：American Journal of Pathology, 页码：2691-2697 , 文章类型： Article，,卷期：2011年179-6]
- Apelin, the ligand of the G protein-coupled receptor APJ, is involved in the regulation of cardiovascular functions, fluid homeostasis, and vessel formation. Recent reports indicate that apelin secreted from endothelial ...
- Increased Expression of 14-3-3 beta Promotes Tumor Progression and Predicts Extrahepatic Metastasis and Worse Survival in Hepatocellular Carcinoma
[作者：Liu, TA; Jan, YJ; Ko, BS; Chen, SC; Liang, SM; Hung, YL; Hsu, C; Shen, TL; Lee, YM; Chen, PF; Wang, J; Shyue, SK; Liou, JY,期刊：American Journal of Pathology, 页码：2698-2708 , 文章类型： Article，,卷期：2011年179-6]
- 14-3-3 beta is implicated in cell survival, proliferation, migration, and tumor growth; however, its clinical relevance in tumor progression and metastasis have never been elucidated. To evaluate the clinical significanc...
- MALDI Imaging Identifies Prognostic Seven-Protein Signature of Novel Tissue Markers in Intestinal-Type Gastric Cancer
[作者：Balluff, B; Rauser, S; Meding, S; Elsner, M; Schone, C; Feuchtinger, A; Schuhmacher, C; Novotny, A; Jutting, U; Maccarrone, G; Sarioglu, H; Ueffing, M; Braselmann, H; Zitzelsberger, H; Schmid, RM; Hofler, H; Ebert, MP; Walch, A,期刊：American Journal of Pathology, 页码：2720-2729 , 文章类型： Article，,卷期：2011年179-6]
- Proteomics-based approaches allow us to investigate the biology of cancer beyond genomic initiatives. We used histology-based matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry to identify prot...
- Diesel Exhaust Particulates Exacerbate Asthma-Like Inflammation by Increasing CXC Chemokines
[作者：Kim, J; Natarajan, S; Vaickus, LJ; Bouchard, JC; Beal, D; Cruikshank, WW; Remick, DG,期刊：American Journal of Pathology, 页码：2730-2739 , 文章类型： Article，,卷期：2011年179-6]
- Particulate matter heavily pollutes the urban atmosphere, and several studies show a link between increased ambient particulate air pollution and exacerbation of pre-existing pulmonary diseases, including asthma. We inve...
- GGPPS, a New EGR-1 Target Gene, Reactivates ERK 1/2 Signaling through Increasing Ras Prenylation
[作者：Shen, N; Shao, Y; Lai, SS; Qiao, L; Yang, RL; Xue, B; Pan, FY; Chen, HQ; Li, CJ,期刊：American Journal of Pathology, 页码：2740-2750 , 文章类型： Article，,卷期：2011年179-6]
- Cigarette smoke activates the extracellular signal-regulated kinase (ERK) 1/2 mitogen activated-protein kinase pathway, which, in turn, is responsible for early growth response gene-1 (EGR-1) activation. Here we provide ...
- Relaxin Regulates Myofibroblast Contractility and Protects against Lung Fibrosis
[作者：Huang, XW; Gai, Y; Yang, NH; Lu, BG; Samuel, CS; Thannickal, VJ; Zhou, Y,期刊：American Journal of Pathology, 页码：2751-2765 , 文章类型： Article，,卷期：2011年179-6]
- Myofibroblasts are specialized contractile cells that participate in tissue fibrosis and remodeling, including idiopathic pulmonary fibrosis (IPF). Mechanotransduction, a process by which mechanical stimuli are converted...
- Focal Adhesion Kinase Signaling Mediates Acute Renal Injury Induced by Ischemia/Reperfusion
[作者：Qin, Y; Alderliesten, MC; Stokman, G; Pennekamp, P; Bonventre, JV; de Heer, E; Ichimura, T; de Graauw, M; Price, LS; van de Water, B,期刊：American Journal of Pathology, 页码：2766-2778 , 文章类型： Article，,卷期：2011年179-6]
- Renal ischemia/reperfusion (I/R) injury is associated with cell matrix and focal adhesion remodeling. Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase that localizes at focal adhesions and regulates t...
- Stachybotrys chartarum-Induced Hypersensitivity Pneumonitis Is TLR9 Dependent
[作者：Bhan, U; Newstead, MJ; Zeng, XY; Ballinger, MN; Standiford, LR; Standiford, TJ,期刊：American Journal of Pathology, 页码：2779-2787 , 文章类型： Article，,卷期：2011年179-6]
- Hypersensitivity pneumonitis (HP), an inflammatory lung disease, develops after repeated exposure to inhaled particulate antigen and is characterized by a vigorous T helper type 1-mediated immune response, resulting in t...
- Neuroglobin Is an Endogenous Neuroprotectant for Retinal Ganglion Cells against Glaucomatous Damage
[作者：Wei, X; Yu, ZY; Cho, KS; Chen, HH; Malik, MTA; Chen, XM; Lo, EH; Wang, XY; Chen, DF,期刊：American Journal of Pathology, 页码：2788-2797 , 文章类型： Article，,卷期：2011年179-6]
- Neuroglobin (NGB), a newly discovered member of the globin superfamily, may regulate neuronal survival under hypoxia or oxidative stress. Although NGB is greatly expressed in retinal neurons, the biological functions of ...
- Critical Involvement of Extracellular ATP Acting on P2RX7 Purinergic Receptors in Photoreceptor Cell Death
[作者：Notomi, S; Hisatomi, T; Kanemaru, T; Takeda, A; Ikeda, Y; Enaida, H; Kroemer, G; Ishibashi, T,期刊：American Journal of Pathology, 页码：2798-2809 , 文章类型： Article，,卷期：2011年179-6]
- Stressed cells release ATP, which participates in neurodegenerative processes through the specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP and the more specific P2RX7 agonist, ...
- Glyoxalase I Retards Renal Senescence
[作者：Ikeda, Y; Inagi, R; Miyata, T; Nagai, R; Arai, M; Miyashita, M; Itokawa, M; Fujita, T; Nangaku, M,期刊：American Journal of Pathology, 页码：2810-2821 , 文章类型： Article，,卷期：2011年179-6]
- Although kidney functions deteriorate with age, little is known about the general morphological alterations and mechanisms of renal senescence. We hypothesized that carbonyl stress causes senescence and investigated the ...
- Heat Shock Protein 72 Enhances Autophagy as a Protective Mechanism in Lipopolysaccharide-Induced Peritonitis in Rats
[作者：Li, S; Zhou, Y; Fan, JJ; Cao, SR; Cao, T; Huang, FX; Zhuang, SG; Wang, YH; Yu, XQ; Mao, HP,期刊：American Journal of Pathology, 页码：2822-2834 , 文章类型： Article，,卷期：2011年179-6]
- Peritoneal dialysis related peritonitis causes the denudation of mesothelial cells and, ultimately, membrane integrity alterations and peritoneal dysfunction. Because heat shock protein 72 (HSP72) confers protection agai...
- Increased Expression of Versican in the Inflammatory Response to UVB- and Reactive Oxygen Species-Induced Skin Tumorigenesis
[作者：Kunisada, M; Yogianti, F; Sakumi, K; Ono, R; Nakabeppu, Y; Nishigori, C,期刊：American Journal of Pathology, 页码：3056-3065 , 文章类型： Article，,卷期：2011年179-6]
- Excessive exposure to UV radiation is a major risk factor for developing skin cancer. UV-induced reactive oxygen species (ROS) cause accumulation of DNA damage products such as 8-oxoguanine (8-oxoG) in the skin. We have ...
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