- Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test
[作者:Schofield, L; Watson, N; Grieu, F; Li, WQ; Zeps, N; Harvey, J; Stewart, C; Abdo, M; Goldblatt, J; Iacopetta, B,期刊:International Journal of Cancer, 页码:1097-1102 , 文章类型: Article,,卷期:2009年124-5]
- Approximately 1-2% of colorectal cancers (CRC) arise because of germline mutations in DNA mismatch repair genes, referred to as Lynch syndrome. These tumours show microsatellite instability (MSI) and loss of expression o...
- Hormone escape is associated with genomic instability in a human prostate cancer model
[作者:Legrier, ME; Guyader, C; Ceraline, J; Dutrillaux, B; Oudard, S; Poupon, MF; Auger, N,期刊:International Journal of Cancer, 页码:1103-1111 , 文章类型: Article,,卷期:2009年124-5]
- Lack of hormone dependency in prostate cancers is an irreversible event that occurs through generation of genomic instability induced by androgen deprivation. Indeed, the cytogenetic profile of hormone-dependent (HD) pro...
- HAMLET (human alpha-lactalbumin made lethal to tumor cells) triggers autophagic tumor cell death
[作者:Aits, S; Gustafsson, L; Hallgren, O; Brest, P; Gustafsson, M; Trulsson, M; Mossberg, AK; Simon, HU; Mograbi, B; Svanborg, C,期刊:International Journal of Cancer, 页码:1008-1019 , 文章类型: Article,,卷期:2009年124-5]
- HAMLET, a complex of partially unfolded a-lactalbumin and oleic acid, kills a wide range of tumor cells. Here we propose that HAMLET causes macroautophagy in tumor cells and that this contributes to their death. Cell dea...
- EBV-encoded LMP1 regulates Op18/stathmin signaling pathway by cdc2 mediation in nasopharyngeal carcinoma cells
[作者:Lin, XC; Liu, SF; Luo, XJ; Ma, XQ; Guo, LL; Li, LL; Li, ZJ; Tao, YG; Cao, Y,期刊:International Journal of Cancer, 页码:1020-1027 , 文章类型: Article,,卷期:2009年124-5]
- Oncoprotein 18/stathmin (Op18/stathmin) plays a crucial role in maintaining cell biological characteristics by regulating microtubule dynamics, especially entry into mitosis; phosphorylated Op18/stathmin promotes microtu...
- Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase
[作者:Ye, L; Gho, WM; Chan, FL; Chen, S; Leung, LK,期刊:International Journal of Cancer, 页码:1028-1036 , 文章类型: Article,,卷期:2009年124-5]
- Licorice is the sweet-tasting rhizomes of a bean plant and is quite commonly used in Western countries for culinary purposes, while it is a medicinal herb in China. Many flavonoids have been isolated from licorice; and t...
- Chromosomes 6 and 18 induce neoplastic suppression in epithelial ovarian cancer cells
[作者:Dafou, D; Ramus, SJ; Choi, K; Grun, B; Trott, DA; Newbold, RF; Jacobs, IJ; Jones, C; Gayther, SA,期刊:International Journal of Cancer, 页码:1037-1044 , 文章类型: Article,,卷期:2009年124-5]
- Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome tran...
- Functional significance of VEGFR-2 on ovarian cancer cells
[作者:Spannuth, WA; Nick, AM; Jennings, NB; Armaiz-Pena, GN; Mangala, LS; Danes, CG; Lin, YG; Merritt, WM; Thaker, PH; Kamat, AA; Han, LY; Tonra, JR; Coleman, RL; Ellis, LM; Sood, AK,期刊:International Journal of Cancer, 页码:1045-1053 , 文章类型: Article,,卷期:2009年124-5]
- Vascular endothelial growth factor receptor (VEGFR) has recently been discovered on ovarian cancer cells, but its functional significance is unknown and is the focus of this study. By protein analysis, A2780-par and HevA...
- Increased fetal cell microchimerism in high grade breast carcinomas occurring during pregnancy
[作者:Dubernard, G; Oster, M; Chareyre, F; Antoine, M; Rouzier, R; Uzan, S; Aractingi, S; Khosrotehrani, K,期刊:International Journal of Cancer, 页码:1054-1059 , 文章类型: Article,,卷期:2009年124-5]
- Pregnancy results in the transfer of stem cells from the fetus to the maternal circulation. These cells are able to migrate and differentiate within various damaged maternal tissues. We recently showed the presence of fe...
- Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells
[作者:Shingu, T; Fujiwara, K; Bogler, O; Akiyama, Y; Moritake, K; Shinojima, N; Tamada, Y; Yokoyama, T; Kondo, S,期刊:International Journal of Cancer, 页码:1060-1071 , 文章类型: Article,,卷期:2009年124-5]
- Malignant gliomas are common primary tumors of the central nervous system. The prognosis of patients with malignant glioma is poor in spite of current intensive therapy and thus novel therapeutic modalities are necessary...
- SRPX2 is overexpressed in gastric cancer and promotes cellular migration and adhesion
[作者:Tanaka, K; Arao, T; Maegawa, M; Matsumoto, K; Kaneda, H; Kudo, K; Fujita, Y; Yokote, H; Yanagihara, K; Yamada, Y; Okamoto, I; Nakagawa, K; Nishio, K,期刊:International Journal of Cancer, 页码:1072-1080 , 文章类型: Article,,卷期:2009年124-5]
- SRPX2 (Sushi repeat containing protein, X-linked 2) was first identified as a downstream molecule of the E2A-HLF fusion gene in t(17;19)-positive leukemia cells and the biological function of this gene remains unknown. W...
- Inhibition of colorectal cancer by targeting hepatocyte nuclear factor-4 alpha
[作者:Schwartz, B; Algamas-Dimantov, A; Hertz, R; Nataf, J; Kerman, A; Peri, I; Bar-Tana, J,期刊:International Journal of Cancer, 页码:1081-1089 , 文章类型: Article,,卷期:2009年124-5]
- Hepatocyte nuclear factor-4 alpha (HNIF-4 alpha) serves as target for fatty acid nutrients and xenobiotic amphipathic carboxylates and may account for the differential effects of dietary fatty acids on colorectal cancer ...
- Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: An explanation for the molecular role of tobacco smoking in cervical carcinogenesis?
[作者:Calleja-Macias, IE; Kalantari, M; Bernard, HU,期刊:International Journal of Cancer, 页码:1090-1096 , 文章类型: Article,,卷期:2009年124-5]
- We have analyzed the expression of mRNAs encoding nicotinic acetylcholine receptors (nAChRs) in CaSki, SiHa and HeLa cell lines, which are derived from two squamous and one adenocarcinoma of the cervix, respectively. We ...
- Characteristic gene expression in stromal cells of gastric cancers among atomic-bomb survivors
[作者:Oue, N; Sentani, K; Sakamoto, N; Motoshita, J; Nishisaka, T; Fukuhara, T; Matsuura, H; Sasaki, H; Nakachi, K; Yasui, W,期刊:International Journal of Cancer, 页码:1112-1121 , 文章类型: Article,,卷期:2009年124-5]
- To elucidate the mechanism of radiation-induced cancers, molecular analysis of cancers in atomic-bomb survivors is important. In our study, we developed a custom oligonucleotide array of 208 genes. We analyzed gene expre...
- Global expression profiling of sex cord stromal tumors from Men1 heterozygous mice identifies altered TGF-beta signaling, decreased Gata6 and increased Csf1r expression
[作者:Mould, AW; Duncan, R; Serewko-Auret, M; Loffler, KA; Biondi, C; Gartside, M; Kay, GF; Hayward, NK,期刊:International Journal of Cancer, 页码:1122-1132 , 文章类型: Article,,卷期:2009年124-5]
- Heterozygous disruption of the Men1 gene predisposes mice to the development of multiple endocrine tumors, accurately mimicking the human MEN1 cancer predisposition syndrome. Additionally, Men1(+/+) mice frequently devel...
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