- Pigment epithelium-derived factor as an anticancer drug and new treatment methods following the discovery of its receptors: a patent perspective
[作者:Manalo, KB; Choong, PFM; Becerra, SP; Dass, CR,期刊:Expert Opinion on Therapeutic Patents, 页码:121-130 , 文章类型: Article,,卷期:2011年21-2]
- Traditional forms of cancer therapy, which include chemotherapy, have largely been overhauled due to the significant degree of toxicity they pose to normal, otherwise healthy tissue. It is hoped that the use of biologica...
- Novel gamma-secretase modulators: a review of patents from 2008 to 2010
[作者:Pettersson, M; Kauffman, GW; Ende, CWA; Patel, NC; Stiff, C; Tran, TP; Johnson, DS,期刊:Expert Opinion on Therapeutic Patents, 页码:205-226 , 文章类型: Review,,卷期:2011年21-2]
- Introduction: The amyloid precursor protein is first cleaved by beta-secretase to generate a 99-residue membrane-bound CTF (C99 or beta-CTF), which is subsequently cleaved by gamma-secretase to generate amyloid beta (A b...
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