- Phosphorylation of GSK-3 beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
[作者:Kawasaki, Y; Kugimiya, F; Chikuda, H; Kamekura, S; Ikeda, T; Kawamura, N; Saito, T; Shinoda, Y; Higashikawa, A; Yano, F; Ogasawara, T; Ogata, N; Hoshi, K; Hofmann, F; Woodgett, JR; Nakamura, K; Chung, UI; Kawaguchi, H,期刊:Journal of clinical investigation, 页码:2506-2515 , 文章类型: Article,,卷期:2008年118-7]
- cGMP-dependent protein kinase II (cGKII; encoded by PRKG2) is a serine/threonine kinase that is critical for skeletal growth in mammals; in mice, cGKII deficiency results in dwarfism. Using radiographic analysis, we dete...
- DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
[作者:Meira, LB; Bugni, JM; Green, SL; Lee, CW; Pang, B; Borenshtein, D; Rickman, BH; Rogers, AB; Moroski-Erkul, CA; McFaline, JL; Schauer, DB; Dedon, PC; Fox, JG; Samson, LD,期刊:Journal of clinical investigation, 页码:2516-2525 , 文章类型: Article,,卷期:2008年118-7]
- Chronic inflammation increases cancer risk. While it is clear that cell signaling elicited by inflammatory cytokines promotes tumor development, the impact of DNA damage production resulting from inflammation-associated ...
- Succinate receptor GPR91 provides a direct link between high glucose bevels and renin release in murine and rabbit kidney
[作者:Toma, I; Kang, JJ; Sipos, A; Vargas, S; Bansal, E; Hanner, F; Meer, E; Peti-Peterdi, J,期刊:Journal of clinical investigation, 页码:2526-2534 , 文章类型: Article,,卷期:2008年118-7]
- Diabetes mellitus is the most common and rapidly growing cause of end-stage renal disease in developed countries. A classic hallmark of early diabetes mellitus includes activation of the renin-angiotensin system (RAS), w...
- VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis
[作者:Cosen-Binker, LI; Binker, MG; Wang, CC; Hong, WJ; Gaisano, HY,期刊:Journal of clinical investigation, 页码:2535-2551 , 文章类型: Article,,卷期:2008年118-7]
- In rodents and humans, alcohol exposure has been shown to predispose the pancreas to cholinergic or viral induction of pancreatitis. We previously developed a rodent model in which exposure to an ethanol (EtOH) diet, fol...
- Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice
[作者:Kubota, Y; Hirashima, M; Kishi, K; Stewart, CL; Suda, T,期刊:Journal of clinical investigation, 页码:2393-2403 , 文章类型: Article,,卷期:2008年118-7]
- To meet tissue requirements for oxygen, capillaries must be properly distributed without excess or shortage. In this process, tissue oxygen concentration is well known to determine capillary density via the hypoxia-induc...
- The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6
[作者:Mudter, J; Amoussina, L; Schenk, M; Yu, JL; Bruestle, A; Weigmann, B; Atreya, R; Wirtz, S; Becker, C; Hoffman, A; Atreya, I; Biesterfeld, S; Galle, PR; Lehr, HA; Rose-John, S; Mueller, C; Lohoff, M; Neurath, MF,期刊:Journal of clinical investigation, 页码:2415-2426 , 文章类型: Article,,卷期:2008年118-7]
- The proinflammatory cytokine IL-6 seems to have an important role in the intestinal inflammation that characterizes inflammatory bowel diseases (IBDs) such as Crohn disease and ulcerative colitis. However, little is know...
- Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug
[作者:Ramsay, AG; Johnson, AJ; Lee, AM; Gorgun, G; Le Dieu, R; Blum, W; Byrd, JC; Gribben, JG,期刊:Journal of clinical investigation, 页码:2427-2437 , 文章类型: Article,,卷期:2008年118-7]
- Cancer is associated with immune deficiency, but the biologic basis of this is poorly defined. Here we demonstrate that impaired actin polymerization results in CD4(+) and CD8(+) T cells from patients with chronic lympho...
- Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin
[作者:Kessenbrock, K; Frohlich, L; Sixt, M; Lammermann, T; Pfister, H; Bateman, A; Belaaouaj, A; Ring, J; Ollert, M; Fassler, R; Jenne, DE,期刊:Journal of clinical investigation, 页码:2438-2447 , 文章类型: Article,,卷期:2008年118-7]
- Neutrophil granulocytes form the body's first line of antibacterial defense, but they also contribute to tissue injury and noninfectious, chronic inflammation. Proteinase 3 (PR3) and neutrophil. elastase (NE) are 2 abund...
- Measles virus blind to its epithelial cell receptor remains virulent in rhesus monkeys but cannot cross the airway epithelium and is not shed
[作者:Leonard, VHJ; Sinn, PL; Hodge, G; Miest, T; Devaux, P; Oezguen, N; Braun, W; McCray, PB; McChesney, MB; Cattaneo, R,期刊:Journal of clinical investigation, 页码:2448-2458 , 文章类型: Article,,卷期:2008年118-7]
- The current model of measles virus (MV) pathogenesis implies that apical infection of airway epithelial cells precedes systemic spread. An alternative model suggests that primarily infected lymphatic cells carry MV to th...
- Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice
[作者:Jain, RN; Al-Menhaii, AA; Keeley, TM; Ren, JH; EI-Zaatari, M; Chen, XS; Merchant, JL; Ross, TS; Chew, CS; Samuelson, LC,期刊:Journal of clinical investigation, 页码:2459-2470 , 文章类型: Article,,卷期:2008年118-7]
- Huntingtin interacting protein 1 related (Hip1r) is an F-actin- and clathrin-binding protein involved in vesicular trafficking. In this study, we demonstrate that Hip1r is abundantly expressed in the gastric parietal cel...
- Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia
[作者:Xie, XM; Wisor, JP; Hara, J; Crowder, TL; LeWinter, R; Khroyan, TV; Yamanaka, A; Diano, S; Horvath, TL; Sakurai, T; Toll, L; Kilduff, TS,期刊:Journal of clinical investigation, 页码:2471-2481 , 文章类型: Article,,卷期:2008年118-7]
- Stress-induced analgesia (SIA) is a key component of the defensive behavioral "fight-or-flight" response. Although the neural substrates of SIA are incompletely understood, previous studies have implicated the hypocretin...
- Implantation of olfactory ensheathing cells promotes neuroplasticity in murine models of stroke
[作者:Shyu, WC; Liu, DD; Lin, SZ; Li, WW; Su, CY; Chang, YC; Wang, HJ; Wang, HW; Tsai, CH; Li, H,期刊:Journal of clinical investigation, 页码:2482-2495 , 文章类型: Article,,卷期:2008年118-7]
- Murine olfactory ensheathing cells (OECs) promote central nervous system axonal regeneration in models of spinal cord injury. We investigated whether OECs could induce a neuroplastic effect to improve the neurological dy...
- Mutations in the nervous system-specific HSN2 exon of WNK1 cause hereditary sensory neuropathy type II
[作者:Shekarabi, M; Girard, N; Riviere, JB; Dion, P; Houle, M; Toulouse, A; Lafreniere, RG; Vercauteren, F; Hince, P; Laganiere, J; Rochefort, D; Faivre, L; Samuels, M; Rouleau, GA,期刊:Journal of clinical investigation, 页码:2496-2505 , 文章类型: Article,,卷期:2008年118-7]
- Hereditary sensory and autonomic neuropathy type II (HSANII) is an early-onset autosomal recessive disorder characterized by loss of perception to pain, touch, and heat due to a loss of peripheral sensory nerves. Mutatio...
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