- Small interfering RNA targeting CD81 ameliorated arthritis in rats
[作者:Nakagawa, S; Arai, Y; Mori, H; Matsushita, Y; Kubo, T; Nakanishi, T,期刊:Biochemical and Biophysical Research Communications, 页码:467-472 , 文章类型: Article,,卷期:2009年388-3]
- CD81 belongs to a family of cell-surface protein ( tetraspanin) known as one of the up-regulated elements in rheumatoid arthritis synoviocytes. In this study, the therapeutic effect of small interfering RNA targeting CD8...
- Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling
[作者:Rawal, N; Corti, O; Sacchetti, P; Ardilla-Osorio, H; Sehat, B; Brice, A; Arenas, E,期刊:Biochemical and Biophysical Research Communications, 页码:473-478 , 文章类型: Article,,卷期:2009年388-3]
- Parkinson's disease (PD) is caused by degeneration of the dopaminergic (DA) neurons of the substantia nigra but the molecular mechanisms underlying the degenerative process remain elusive. Several reports suggest that ce...
- MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer
[作者:Crawford, M; Batte, K; Yu, LB; Wu, X; Nuovo, GJ; Marsh, CB; Otterson, GA; Nana-Sinkam, SP,期刊:Biochemical and Biophysical Research Communications, 页码:483-489 , 文章类型: Article,,卷期:2009年388-3]
- Lung cancer is the most frequent cause of cancer-related death in this country for men and women. MicroRNAs ( miRNAs) are a family of small non-coding RNAs ( approximately 21-25 nt long) capable of targeting genes for ei...
- Helicobacter pylori causes runx3 gene methylation and its loss of expression in gastric epithelial cells, which is mediated by nitric oxide produced by macrophages
[作者:Katayama, Y; Takahashi, M; Kuwayama, H,期刊:Biochemical and Biophysical Research Communications, 页码:496-500 , 文章类型: Article,,卷期:2009年388-3]
- Previous reports have indicated that Helicobacter pylori ( H. pylori) causes epigenetic changes of certain genes such as cancer suppression genes, which may be associated with carcinogenesis. However, the mechanism by wh...
- YKL-40 secreted from adipose tissue inhibits degradation of type I collagen
[作者:Iwata, T; Kuwajima, M; Sukeno, A; Ishimaru, N; Hayashi, Y; Wabitsch, M; Mizusawa, N; Itakura, M; Yoshimoto, K,期刊:Biochemical and Biophysical Research Communications, 页码:511-516 , 文章类型: Article,,卷期:2009年388-3]
- Obesity is considered a chronic low-grade inflammatory status and the stromal vascular fraction (SVF) cells of adipose tissue ( AT) are considered a source of inflammation-related molecules. We identified YKL-40 as a maj...
- Hypertrophic response to angiotensin II is mediated by protein kinase D-extracellular signal-regulated kinase 5 pathway in human aortic smooth muscle cells
[作者:Geng, J; Zhao, Z; Kang, WQ; Wang, W; Liu, GH; Sun, YY; Zhang, Y; Ge, ZM,期刊:Biochemical and Biophysical Research Communications, 页码:517-522 , 文章类型: Article,,卷期:2009年388-3]
- Angiotensin II plays a critical role in hypertrophy of vascular smooth muscle cells, however, the molecular underpinnings remain unclear. The present study indicated that AT(1)/PKC/PKD pathway was able to regulate downst...
- Cell-cell bond modulates vascular smooth muscle cell responsiveness to Angiotensin II
[作者:Barisione, C; Mura, M; Garibaldi, S; Fabbi, P; Altieri, P; Passalacqua, M; Salani, B; Ghigliotti, G; Aloi, C; Spallarossa, P; Brunelli, C,期刊:Biochemical and Biophysical Research Communications, 页码:523-528 , 文章类型: Article,,卷期:2009年388-3]
- Cell attachment is provided by cell-matrix and cell-cell bonds, and acts as a regulator of vascular smooth muscle cell (VSMC) survival, activity and homeostasis, as well as of VSMCs response to pathogenic stimuli. In thi...
- Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast
[作者:Shimada, M; Yamamoto, A; Murakami-Tonami, Y; Nakanishi, M; Yoshida, T; Aiba, H; Murakami, H,期刊:Biochemical and Biophysical Research Communications, 页码:529-532 , 文章类型: Article,,卷期:2009年388-3]
- The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the C...
- MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells
[作者:Yao, Q; Xu, H; Zhang, QQ; Zhou, H; Qu, LH,期刊:Biochemical and Biophysical Research Communications, 页码:539-542 , 文章类型: Article,,卷期:2009年388-3]
- MicroRNAs are involved in cancer-related processes. The microRNA-21(miR-21) has been identified as the only miRNA over-expressed in a wide variety of cancers, including cervical cancer. However, the function of miR-21 is...
- LRRC19, a novel member of the leucine-rich repeat protein family, activates NF-kappa B and induces expression of proinflammatory cytokines
[作者:Chai, LM; Dai, LY; Che, YZ; Xu, J; Liu, GJ; Zhang, ZJ; Yang, RC,期刊:Biochemical and Biophysical Research Communications, 页码:543-548 , 文章类型: Article,,卷期:2009年388-3]
- We have identified a new functional transmembrane receptor, LRRC19 (leucine-rich repeat containing 19), that belongs to the LRR protein family. LRRC19's central core has four analogous LRR repeating modules in a juxtapos...
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