Mucosal immunoregulation involves the unique cross-talk between epithelial cells and various immune system components. Mucosal secretions contain significant quantities of immunoglobulin (Ig) G. The neonatal Fc recept...

Background: The use of antipsychotic medication for disparate psychiatric and medical disorders has increased rapidly during the past decade. Newer second-generation antipsychotic agents have largely replaced older ag...

Background: Leukotriene A(4) hydrolase (LTA(4)H) is a ubiquitously distributed 69-kDa zinc-conotaining cytosolic enzyme with both hydrolase and amino-peptidase activity. As a hydrolase, LTA(4)H stereospecifically cata...

Background: Although alpha(1) adrenergic receptor blockers can be very effective for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS), their usage is limited by cardiovascular-rela...

Background: Potassium channels represent a rich source of potential targets for therapeutic intervention. Clinically used potassium channel modulators comprise the sulfonylurea hypoglycemic agents (e.g., nateglinide, ...

Background: Clostridium difficile infection has become a serious concern in both hospital and secondary healthcare environments. In the presence of repeated or prolonged antibiotic treatment, the C. difficile spores c...

Background: Atropic vaginitis is the result of a significant decrease in estrogen levels. This frequent complaint is characterized by dryness and inflammation of the vagina with thinning of the urogenital epithelium. ...

Background: Cancer stem cells (CSCs) are a small subpopulation of the tumour mass that are capable of sustaining its growth, are resistant to many cancer specific therapies, and can reinitiate disease relapse. CSCs ar...