- Novel Hyperactive Transposons for Genetic Modification of Induced Pluripotent and Adult Stem Cells: A Nonviral Paradigm for Coaxed Differentiation
[作者：Belay, E; Matrai, J; Acosta-Sanchez, A; Ma, L; Quattrocelli, M; Mates, L; Sancho-Bru, P; Geraerts, M; Yan, B; Vermeesch, J; Rincon, MY; Samara-Kuko, E; Ivics, Z; Verfaillie, C; Sampaolesi, M; Izsvak, Z; VandenDriessche, T; Chuah, MKL,期刊：Stem Cells, 页码：1760-1771 , 文章类型： Article，,卷期：2010年28-10]
- Adult stem cells and induced pluripotent stem cells (iPS) hold great promise for regenerative medicine. The development of robust nonviral approaches for stem cell gene transfer would facilitate functional studies and po...
- Neural Induction Intermediates Exhibit Distinct Roles of Fgf Signaling
[作者：Sterneckert, J; Stehling, M; Bernemann, C; Arauzo-Bravo, MJ; Greber, B; Gentile, L; Ortmeier, C; Sinn, M; Wu, GM; Ruau, D; Zenke, M; Brintrup, R; Klein, DC; Ko, K; Scholer, HR,期刊：Stem Cells, 页码：1772-1781 , 文章类型： Article，,卷期：2010年28-10]
- Formation of the neural plate is an intricate process in early mammalian embryonic development mediated by cells of the inner cell mass and involving a series of steps, including development of the epiblast. Here, we rep...
- Ascorbate Promotes Epigenetic Activation of CD30 in Human Embryonic Stem Cells
[作者：Chung, TL; Turner, JP; Thaker, NY; Kolle, G; Cooper-White, JJ; Grimmond, SM; Pera, MF; Wolvetang, EJ,期刊：Stem Cells, 页码：1782-1793 , 文章类型： Article，,卷期：2010年28-10]
- Human embryonic stem cells (hESCs) and induced pluripotent stem cells have the ability to adapt to various culture conditions. Phenotypic and epigenetic changes brought about by the culture conditions can, however, have ...
- Gli1 Is an Inducing Factor in Generating Floor Plate Progenitor Cells from Human Embryonic Stem Cells
[作者：Denham, M; Thompson, LH; Leung, J; Pebay, A; Bjorklund, A; Dottori, M,期刊：Stem Cells, 页码：1805-1815 , 文章类型： Article，,卷期：2010年28-10]
- Generation of mesencephalic dopamine (mesDA) neurons from human embryonic stem cells (hESCs) requires several stages of signaling from various extrinsic and intrinsic factors. To date, most methods incorporate exogenous ...
- Differential Regulation of Proliferation and Differentiation in Neural Precursor Cells by the Jak Pathway
[作者：Kim, YH; Chung, JI; Woo, HG; Jung, YS; Lee, SH; Moon, CH; Suh-Kim, H; Baik, EJ,期刊：Stem Cells, 页码：1816-1828 , 文章类型： Article，,卷期：2010年28-10]
- Neuronal precursor cells (NPCs) are temporally regulated and have the ability to proliferate and differentiate into mature neurons, oligodendrocytes, and astrocytes in the presence of growth factors (GFs). In the present...
- Undifferentiated Embryonic Cell Transcription Factor 1 Regulates ESC Chromatin Organization and Gene Expression
[作者：Kooistra, SM; van den Boom, V; Thummer, RP; Johannes, F; Wardenaar, R; Tesson, BM; Veenhoff, LM; Fusetti, F; O'Neill, LP; Turner, BM; de Haan, G; Eggen, BJL,期刊：Stem Cells, 页码：1703-1714 , 文章类型： Article，,卷期：2010年28-10]
- Previous reports showed that embryonic stem (ES) cells contain hyperdynamic and globally transcribed chromatin-properties that are important for ES cell pluripotency and differentiation. Here, we demonstrate a role for u...
- Proteomic Analysis of Sox2-Associated Proteins During Early Stages of Mouse Embryonic Stem Cell Differentiation Identifies Sox21 as a Novel Regulator of Stem Cell Fate
[作者：Mallanna, SK; Ormsbee, BD; Iacovino, M; Gilmore, JM; Cox, JL; Kyba, M; Washburn, MP; Rizzino, A,期刊：Stem Cells, 页码：1715-1727 , 文章类型： Article，,卷期：2010年28-10]
Small increases in the levels of master regulators, such as Sox2, in embryonic stem cells (ESC) have been shown to promote their differentiation. However, the mechanism by which Sox2 controls the fate of ESC is poorly...
- Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
[作者：Somers, A; Jean, JC; Sommer, CA; Omari, A; Ford, CC; Mills, JA; Ying, L; Sommer, AG; Jean, JM; Smith, BW; Lafyatis, R; Demierre, MF; Weiss, DJ; French, DL; Gadue, P; Murphy, GJ; Mostoslavsky, G; Kotton, DN,期刊：Stem Cells, 页码：1728-1740 , 文章类型： Article，,卷期：2010年28-10]
- The development of methods to achieve efficient reprogramming of human cells while avoiding the permanent presence of reprogramming transgenes represents a critical step toward the use of induced pluripotent stem cells (...
- High-Efficiency Induction of Neural Conversion in Human ESCs and Human Induced Pluripotent Stem Cells with a Single Chemical Inhibitor of Transforming Growth Factor Beta Superfamily Receptors
[作者：Zhou, JX; Su, P; Li, D; Tsang, S; Duan, EK; Wang, F,期刊：Stem Cells, 页码：1741-1750 , 文章类型： Article，,卷期：2010年28-10]
- Chemical compounds have emerged as powerful tools for modulating ESC functions and deriving induced pluripotent stem cells (iPSCs), but documentation of compound-induced efficient directed differentiation in human ESCs (...
- B-Myb is Critical for Proper DNA Duplication During an Unperturbed S Phase in Mouse Embryonic Stem Cells
[作者：Lorvellec, M; Dumon, S; Maya-Mendoza, A; Jackson, D; Frampton, J; Garcia, P,期刊：Stem Cells, 页码：1751-1759 , 文章类型： Article，,卷期：2010年28-10]
- A common feature of early embryo cells from the inner cell mass (ICM) and of ESCs is an absolute dependence on an atypical cell cycle in which the G1 phase is shortened to preserve their self-renewing and pluripotent nat...
- Allogeneic Periodontal Ligament Stem Cell Therapy for Periodontitis in Swine
[作者：Ding, G; Liu, Y; Wang, W; Wei, FL; Liu, DY; Fan, ZP; An, YQ; Zhang, CM; Wang, SL,期刊：Stem Cells, 页码：1829-1838 , 文章类型： Article，,卷期：2010年28-10]
- Periodontitis is one of the most widespread infectious diseases in humans. It is the main cause of tooth loss and associated with a number of systemic diseases. Until now, there is no appropriate method for functional pe...
- Myoblast-Derived Neuronal Cells Form Glutamatergic Neurons in the Mouse Cerebellum
[作者：Gopalakrishnan, V; Bie, B; Sinnappah-Kang, ND; Adams, H; Fuller, GN; Pan, ZZ; Majumder, S,期刊：Stem Cells, 页码：1839-1847 , 文章类型： Article，,卷期：2010年28-10]
- Production of neurons from non-neural cells has far-reaching clinical significance. We previously found that myoblasts can be converted to a physiologically active neuronal phenotype by transferring a single recombinant ...
- Vitamin C Promotes Widespread Yet Specific DNA Demethylation of the Epigenome in Human Embryonic Stem Cells
[作者：Chung, TL; Brena, RM; Kolle, G; Grimmond, SM; Berman, BP; Laird, PW; Pera, MF; Wolvetang, EJ,期刊：Stem Cells, 页码：1848-1855 , 文章类型： Article，,卷期：2010年28-10]
- Vitamin C (ascorbate) is a widely used medium supplement in embryonic stem cell culture. Here, we show that ascorbate causes widespread, consistent, and remarkably specific DNA demethylation of 1,847 genes in human embry...
- Human Gingiva-Derived Mesenchymal Stem Cells Elicit Polarization of M2 Macrophages and Enhance Cutaneous Wound Healing
[作者：Zhang, QZ; Su, WR; Shi, SH; Wilder-Smith, P; Xiang, AP; Wong, A; Nguyen, AL; Kwon, CW; Le, AD,期刊：Stem Cells, 页码：1856-1868 , 文章类型： Article，,卷期：2010年28-10]
- Increasing evidence has supported the important role of mesenchymal stem cells (MSCs) in wound healing, however, the underlying mechanism remains unclear. Recently, we have isolated a unique population of MSCs from human...
- A Runx1 Intronic Enhancer Marks Hemogenic Endothelial Cells and Hematopoietic Stem Cells
[作者：Ng, CEL; Yokomizo, T; Yamashita, N; Cirovic, B; Jin, H; Wen, ZL; Ito, Y; Osato, M,期刊：Stem Cells, 页码：1869-1881 , 文章类型： Article，,卷期：2010年28-10]
- Runx1 is essential for the generation of hematopoietic stem cells (HSCs) and is frequently mutated in human leukemias. However, the cis-regulatory mechanisms modulating the Runx1 gene expression remain to be elucidated. ...
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