- Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel
[作者:Stuelten, CH; Mertins, SD; Busch, JI; Gowens, M; Scudiero, DA; Burkett, MW; Hite, KM; Alley, M; Hollingshead, M; Shoemaker, RH; Niederhuber, JE,期刊:Stem Cells, 页码:649-660 , 文章类型: Article,,卷期:2010年28-4]
- Tumor stem cells or cancer initiating cells (CICs) are single tumor cells that can regenerate a tumor or a metastasis. The identification and isolation of CICs remain challenging, and a variety of putative CIC markers ha...
- Human Induced Pluripotent Stem Cell Lines Show Stress Defense Mechanisms and Mitochondrial Regulation Similar to Those of Human Embryonic Stem Cells
[作者:Armstrong, L; Tilgner, K; Saretzki, G; Atkinson, SP; Stojkovic, M; Moreno, R; Przyborski, S; Lako, M,期刊:Stem Cells, 页码:661-673 , 文章类型: Article,,卷期:2010年28-4]
- The generation of induced pluripotent stem cells (iPSC) has enormous potential for the development of patient-specific regenerative medicine. Human embryonic stem cells (hESC) are able to defend their genomic integrity b...
- Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells
[作者:Duan, YY; Ma, XC; Zou, W; Wang, C; Bahbahan, IS; Ahuja, TP; Tolstikov, V; Zern, MA,期刊:Stem Cells, 页码:674-686 , 文章类型: Article,,卷期:2010年28-4]
- Human embryonic stem cells (hESCs) may provide a cell source for functional hepatocytes for clinical applications and drug development. Initially, the hESC population was enriched to be more than 85% definitive endoderm ...
- No Evidence for Clonal Selection Due to Lentiviral Integration Sites in Human Induced Pluripotent Stem Cells
[作者:Winkler, T; Cantilena, A; Metais, JY; Xu, XL; Nguyen, AD; Borate, B; Antosiewicz-Bourget, JE; Wolfsberg, TG; Thomson, JA; Dunbar, CE,期刊:Stem Cells, 页码:687-694 , 文章类型: Article,,卷期:2010年28-4]
- Derivation of induced pluripotent stem (iPS) cells requires the expression of defined transcription factors (among Oct3/4, Sox2, Klf4, c-Myc, Nanog, and Lin28) in the targeted cells. Lentiviral or standard retroviral gen...
- Induced Pluripotent Stem Cells Generate Both Retinal Ganglion Cells and Photoreceptors: Therapeutic Implications in Degenerative Changes in Glaucoma and Age-Related Macular Degeneration
[作者:Parameswaran, S; Balasubramanian, S; Babai, N; Qiu, F; Eudy, JD; Thoreson, WB; Ahmad, I,期刊:Stem Cells, 页码:695-703 , 文章类型: Article,,卷期:2010年28-4]
- The direct reprogramming of somatic cells to a pluripotent state holds significant implications for treating intractable degenerative diseases by ex vivo cell therapy. In addition, the reprogrammed cells can serve as a m...
- Hemangioblastic Derivatives from Human Induced Pluripotent Stem Cells Exhibit Limited Expansion and Early Senescence
[作者:Feng, Q; Lu, SJ; Klimanskaya, I; Gomes, I; Kim, D; Chung, Y; Honig, GR; Kim, KS; Lanza, R,期刊:Stem Cells, 页码:704-712 , 文章类型: Article,,卷期:2010年28-4]
- Human induced pluripotent stem cells (hiPSC) have been shown to differentiate into a variety of replacement cell types. Detailed evaluation and comparison with their human embryonic stem cell (hESC) counterparts is criti...
- Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes
[作者:Mali, P; Chou, BK; Yen, J; Ye, ZH; Zou, JZ; Dowey, S; Brodsky, RA; Ohm, JE; Yu, WN; Baylin, SB; Yusa, K; Bradley, A; Meyers, DJ; Mukherjee, C; Cole, PA; Cheng, LZ,期刊:Stem Cells, 页码:713-720 , 文章类型: Article,,卷期:2010年28-4]
- We report here that butyrate, a naturally occurring fatty acid commonly used as a nutritional supplement and differentiation agent, greatly enhances the efficiency of induced pluripotent stem (iPS) cell derivation from h...
- The Senescence-Related Mitochondrial/Oxidative Stress Pathway is Repressed in Human Induced Pluripotent Stem Cells
[作者:Prigione, A; Fauler, B; Lurz, R; Lehrach, H; Adjaye, J,期刊:Stem Cells, 页码:721-733 , 文章类型: Article,,卷期:2010年28-4]
- The ability of stem cells to propagate indefinitely is believed to occur via the fine modulation of pathways commonly involved in cellular senescence, including the telomerase, the p53, and the mitochondrial/oxidative st...
- Nuclear Transfer-Derived Epiblast Stem Cells Are Transcriptionally and Epigenetically Distinguishable from Their Fertilized-Derived Counterparts
[作者:Maruotti, J; Dai, XP; Brochard, V; Jouneau, L; Liu, J; Bonnet-Garnier, A; Jammes, H; Vallier, L; Brons, IGM; Pedersen, R; Renard, JP; Zhou, Q; Jouneau, A,期刊:Stem Cells, 页码:743-752 , 文章类型: Article,,卷期:2010年28-4]
- Mouse embryonic pluripotent stem cells can be obtained from the inner cell mass at the blastocyst stage (embryonic stem cells, ESCs) or from the late epiblast of postimplantation embryos (epiblast stem cells, EpiSCs). Du...
- Isolation of a Highly Myogenic CD34-Negative Subset of Human Skeletal Muscle Cells Free of Adipogenic Potential
[作者:Pisani, DF; Dechesne, CA; Sacconi, S; Delplace, S; Belmonte, N; Cochet, O; Clement, N; Wdziekonski, B; Villageois, AP; Butori, C; Bagnis, C; Di Santo, JP; Kurzenne, JY; Desnuelle, C; Dani, C,期刊:Stem Cells, 页码:753-764 , 文章类型: Article,,卷期:2010年28-4]
- The differentiation of multipotent cells into undesirable lineages is a significant risk factor when performing cell therapy. In muscular diseases, myofiber loss can be associated with progressive fat accumulation that i...
- Engineering Musculoskeletal Tissues with Human Embryonic Germ Cell Derivatives
[作者:Varghese, S; Hwang, NS; Ferran, A; Hillel, A; Theprungsirikul, P; Canver, AC; Zhang, ZJ; Gearhart, J; Elisseeff, J,期刊:Stem Cells, 页码:765-774 , 文章类型: Article,,卷期:2010年28-4]
- The cells derived from differentiating embryoid bodies of human embryonic germ (hEG) cells express a broad spectrum of gene markers and have been induced toward ecto- and endodermal lineages. We describe here in vitro an...
- Chondroitin Sulfates Are Required for Fibroblast Growth Factor-2-Dependent Proliferation and Maintenance in Neural Stem Cells and for Epidermal Growth Factor-Dependent Migration of Their Progeny
[作者:Sirko, S; von Holst, A; Weber, A; Wizenmann, A; Theocharidis, U; Gotz, M; Faissner, A,期刊:Stem Cells, 页码:775-787 , 文章类型: Article,,卷期:2010年28-4]
- The neural stem cell niche of the embryonic and adult forebrain is rich in chondroitin sulfate glycosaminoglycans (CS-GAGs) that represent complex linear carbohydrate structures on the cell surface of neural stem/progeni...
- In Vitro High-Capacity Assay to Quantify the Clonal Heterogeneity in Trilineage Potential of Mesenchymal Stem Cells Reveals a Complex Hierarchy of Lineage Commitment
[作者:Russell, KC; Phinney, DG; Lacey, MR; Barrilleaux, BL; Meyertholen, KE; O'Connor, KC,期刊:Stem Cells, 页码:788-798 , 文章类型: Article,,卷期:2010年28-4]
- In regenerative medicine, bone marrow is a promising source of mesenchymal stem cells (MSCs) for a broad range of cellular therapies. This research addresses a basic prerequisite to realize the therapeutic potential of M...
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