- Raf kinases in cancer-roles and therapeutic opportunities
[作者：Maurer, G; Tarkowski, B; Baccarini, M,期刊：Oncogene, 页码：3477-3488 , 文章类型： Review，,卷期：2011年30-32]
- Raf are conserved, ubiquitous serine/protein kinases discovered as the cellular elements hijacked by transforming retroviruses. The three mammalian RAF proteins (A, B and CRAF) can be activated by the human oncogene RAS,...
- MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways
[作者：Oneyama, C; Ikeda, J; Okuzaki, D; Suzuki, K; Kanou, T; Shintani, Y; Morii, E; Okumura, M; Aozasa, K; Okada, M,期刊：Oncogene, 页码：3489-3501 , 文章类型： Article，,卷期：2011年30-32]
- The tyrosine kinase c-Src is upregulated in various human cancers, but the molecular mechanisms underlying c-Src-mediated tumor growth remain unclear. Here we examined the involvement of microRNAs in the c-Src-mediated t...
- An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis
[作者：Lara, R; Mauri, FA; Taylor, H; Derua, R; Shia, A; Gray, C; Nicols, A; Shiner, RJ; Schofield, E; Bates, PA; Waelkens, E; Dallman, M; Lamb, J; Zicha, D; Downward, J; Seckl, MJ; Pardo, OE,期刊：Oncogene, 页码：3513-3521 , 文章类型： Article，,卷期：2011年30-32]
- We performed a kinome-wide siRNA screen and identified 70 kinases altering cell migration in A549 lung cancer cells. In particular, ribosomal S6 kinase 1 (RSK1) silencing increased, whereas RSK2 and RSK4 downregulation i...
- Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo
[作者：Mullany, LK; Fan, HY; Liu, Z; White, LD; Marshall, A; Gunaratne, P; Anderson, ML; Creighton, CJ; Xin, L; Deavers, M; Wong, KK; Richards, JS,期刊：Oncogene, 页码：3522-3536 , 文章类型： Article，,卷期：2011年30-32]
- Ovarian cancer is a complex and deadly disease that remains difficult to detect at an early curable stage. Furthermore, although some oncogenic (Kras, Pten/PI3K and Trp53) pathways that are frequently mutated, deleted or...
- Blockade of the NF kappa B pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo
[作者：Nogueira, L; Ruiz-Ontanon, P; Vazquez-Barquero, A; Lafarga, M; Berciano, MT; Aldaz, B; Grande, L; Casafont, I; Segura, V; Robles, EF; Suarez, D; Garcia, LF; Martinez-Climent, JA; Fernandez-Luna, JL,期刊：Oncogene, 页码：3537-3548 , 文章类型： Article，,卷期：2011年30-32]
- Glioblastoma multiforme is one of the most devastating cancers and presents unique challenges to therapy because of its aggressive behavior. Cancer-initiating or progenitor cells have been described to be the only cell p...
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